Group 1 - The core viewpoint of the news highlights the approval of a new innovative drug by Heng Rui Medicine, which is the first self-developed DPP-4 inhibitor combined with metformin in China, aimed at improving blood sugar control for adult patients with type 2 diabetes [1] - Following the announcement, Heng Rui Medicine's stock surged nearly 30% in the Hong Kong market, indicating strong investor confidence in the innovative drug sector [1] - The Hong Kong innovative drug index has seen a significant decrease in its price-to-earnings ratio from 64 times on February 21 to 25 times on May 22, suggesting a favorable investment opportunity in the sector [1] Group 2 - The Hong Kong innovative drug ETF (159567) tracks the National Index for Hong Kong Innovative Drugs, with 90% of its weight in innovative drug companies, positioning it to benefit from trends such as AI-enabled drug development and the expansion of domestic innovative drugs [2] - The larger innovative drug ETF (159992) encompasses leading companies in the innovative drug industry chain, benefiting from advancements in AI, the internationalization of domestic innovative drugs, and the introduction of new healthcare policies [2] - According to Xingye Securities, the innovative drug sector in China is transitioning from a "follower" to a "leader," with significant advancements expected in new targets and technologies by 2025, showcasing strong global competitiveness in areas like ADC, bispecific antibodies, and cell therapy [2]

每经记者｜金喆 陈星 每经编辑｜陈俊杰 5月20日早间，辉瑞引入三生制药PD-1/VEGF双抗的消息，在各大医药群里传开。这次合作，首付款为不可退还和不可抵扣的12.5亿美元，刷新中国创新药 海外授权许可首付款金额纪录。再加上里程碑款项，按照目前汇率计算，合作总金额超过430亿元人民币。 随后几天，港股三生制药股价大涨，子公司三生国健连续3个交易日强势涨停。 另一面，近期，美国总统特朗普频频出招，喊话制药企业必须在美国本土建厂、加大投资，随后又签署药品"降价令"。根据行政令文本，这项政策旨在将美 国的处方药定价与"其他发达国家"进行对标，要求制药公司向美国市场提供"最惠国价格"。这一系列操作，深刻改变着全球制药行业原有的格局，几乎所有 巨头都宣布要在美国加大投资。 风暴之中，定价权，象征着实力。对于中国药企而言，此刻不仅需要重估价值，更需重估自身的力量。而辉瑞与三生制药的合作表明——越来越多跨国巨头 正全面看到中国创新药的价值。 图片来源：VCG211313956599 风暴中：430亿元的生意成了 今年以来，特朗普政府的一系列药品价格新政和喊话，使包括中国医药企业在内的全球医药产业链陷入迷茫和震荡。 特别是 ...

5月22日涨停分析 今日共40股涨停，连板股总数13只，27股封板未遂，封板率为60%（不含ST股、退市股）。焦点股方面，创新药概念股三生国健走出20CM4连板，并购重 组的慧博云通一字涨停晋级20CM3连板；高位股大跌，苏州龙杰、中毅达、红墙股份等跌停。 | 股票名称 | 板数 | 涨跌幅 | 涨停时间 | 上涨逻辑 | | --- | --- | --- | --- | --- | | 滨海能源 | 4天4板 | 9.99% | 09:25 | 并购重线 | | 000695 | | | | | | 宜宾纸业 | 4天4板 | 10.00% | 13:41 | 并购重线 | | 600793 | | | | | | 慧博云通 | 3天3板 | 20.00% | 09:25 | 并购重线 | | 301316 | | | | | | 鸿铭股份 | 首板 | 20.00% | 09:39 | 并购重线 | | 301105 | | | | | | 绿联科技 | | 14.15% | | 并购重线 | | 301606 | | | | | | 新铝时代 | | 11.54% | | 机器人+ | | ONICI ...

小而美、高弹性：港股创新药ETF（159567）跟踪国证港股通创新药指数，创新药企业权重90%为全市 场医药主题类指数中最高，有望把握AI赋能创新药研发、国产创新药出海、商业健康保险逐步完善的 创新药利好浪潮。 欧美市场的高支付能力与创新药的溢价空间，构成国产创新药出海的直接动力。以百济神州的泽布替尼 为例，其美国定价约6.3万元/瓶，而国内医保定价仅为1912元/瓶，中美售价相差超30倍。2025年一季 度，泽布替尼在美国销售额达5.63亿美元，同比增长60%，印证了"闯关欧美发达市场=手握全球通行 证"的商业逻辑。 港股创新药板块高盈利持续消化估值。港股创新药指数2月21日市盈率为64倍，5月22日最新市盈率仅为 25倍，不足两个月前的一半，当前布局性价比突出。 5月22日，港股市场低开震荡，港股创新药板块开盘下跌后快速反弹。港股创新药指数成分股中，金斯 瑞生物科技涨超5%，远大医药、亚盛医药-B、荣昌生物涨超3%，东阳光长江药业、中国生物制药涨超 1%。港股创新药ETF（159567）过去10个交易日资金净流入2.5亿元，市场热度较高。 广发证券认为，港股创新药板块作为具备全球竞争力的产业之一，其出海进 ...

Group 1 - The core point of the news is that 3SBio has signed a licensing agreement with Pfizer for the exclusive development, production, and commercialization of the SSGJ-707 project, with a record-breaking upfront payment of $1.25 billion, marking a significant milestone for Chinese innovative drugs going global [1][4]. - The licensing agreement is part of a broader trend where Chinese innovative drugs are increasingly entering international markets, with a notable increase in licensing deals from 10 projects before 2020 to 39 in 2020 alone, and over 50 licensing events reported in the first quarter of 2025 [4][6]. - The agreement with Pfizer is characterized as a high-value collaboration, placing it among the top global licensing deals, alongside other significant transactions in the innovative drug sector [4][5]. Group 2 - The motivation for Chinese innovative drugs to go global includes the pressure of domestic price controls and the high payment capacity of overseas markets, which offer greater profit margins compared to the domestic market [6][7]. - The competitive landscape in the domestic market is described as "involution," with 70% of clinical products concentrated on only 21% of targets, while the same ratio in overseas markets is only 9.93%, leading to inefficiencies and limited returns for companies [6][7]. - The success of Chinese innovative drugs in international markets is exemplified by the case of Zepzelca, which achieved $563 million in sales in the U.S. in the first quarter of 2025, highlighting the potential for significant revenue generation in developed markets [6][10]. Group 3 - Several Chinese pharmaceutical companies are actively pursuing international expansion, with notable examples including Bai Li Tianheng, which reported a revenue of 5.823 billion yuan in 2024, driven by an $800 million upfront payment from its overseas partner [8]. - BeiGene's innovative drug Zepzelca has become a benchmark for Chinese drugs entering the international market, achieving global sales exceeding $1 billion for the first time, with a price in the U.S. that is 11 times higher than its domestic price [10][11]. - The collaboration between Legend Biotech and Johnson & Johnson for CAR-T products demonstrates the increasing trend of Chinese companies engaging in global partnerships to enhance their competitive edge [11].

Group 1 - The core point of the news is that the company Sanofi Guojian has signed a licensing agreement with Pfizer for the exclusive development, production, and commercialization of the 707 project, which targets both PD-1 and VEGF [1] - Pfizer will pay an upfront fee of $1.25 billion, which sets a new record for upfront payments for domestic innovative drugs going abroad, and the total potential payments could reach up to $4.8 billion [1] - The agreement signifies recognition of the R&D capabilities of domestic innovative drug companies by top international pharmaceutical firms, marking a milestone for domestic pharmaceutical companies in entering the global market [1] Group 2 - The 707 project is a bispecific antibody product that requires internal decision-making processes and regulatory approvals before implementation, indicating some uncertainty in the execution [1] - The domestic pharmaceutical industry has seen significant growth in recent years, supported by domestic pharmaceutical policies and capital market financing policies for innovative drug R&D [1] - Over 25 domestic Class 1 innovative drugs have been approved for listing on the Sci-Tech Innovation Board, and more than 10 innovative drug companies have granted overseas rights to foreign companies through licensing agreements [2]

5月21日，三生国健（688336）再度冲上涨停，这已是公司连续第三个交易日涨停。连续多日涨停背后，是一则引爆创新药行业的重磅消息。 三生国健最新公告显示，三生国健及公司的关联方三生制药和沈阳三生制药有限责任公司（以下简称"沈阳三生"）共同授予被许可方辉瑞公司（Pfizer Inc.）（以下简称"辉瑞"）在许可区域（即除中国大陆以外的其他国家和地区）及领域（即人类和兽医用途的所有治疗、诊断及预防适应症）的独家开发、 生产和商业化许可产品707项目（即同时靶向PD-1和VEGF的双特异性抗体产品）的权利。 | 分时 | 5日 ~ | 5分钟 | 15分钟 | 30分钟 | 60分钟 日线 | 更多周期 · | | | 竟价 ▼ | 叠加· | 田 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | | ◀ 股东大会：于2025-06-05召开2025年第二次临时股东大会 | | | | | | | | | | | | | | 三生国健 所属行业: 生物制品 最新:928.86 涨跌:+1.63% | ...

Group 1 - The core viewpoint is that China's innovative drug BD (business development) transactions are experiencing significant growth in both volume and quality since 2024, with notable increases in upfront payments and total package amounts, indicating international recognition of Chinese innovative drugs [1] - At the 2025 AACR conference, 126 companies showcased nearly 300 research results, with the number of Chinese companies and displayed results reaching historical highs, reflecting international academic recognition of domestic innovative drugs [1] - Despite ongoing US-China tariff frictions since April, multiple BD transactions for drugs have still been completed, demonstrating the strong momentum of innovative drugs going abroad [1] Group 2 - The innovative drug ETF (517110) tracks the SHS Innovative Drug (RMB) Index (931409), which is compiled by China Securities Index Co., Ltd., selecting listed companies involved in the research, production, and sales of innovative drugs from the A-share market [2] - The index aims to reflect the overall performance of innovative drug-related companies in the A-share market, with constituent stocks characterized by significant R&D investment and growth potential [2] - The innovative drug sector is expected to benefit from outbound transactions, AI empowerment across the pharmaceutical industry, and the implementation of innovative drug category B medical insurance, leading to potential increases in profitability and valuation [1]

消息面上，2025年美国临床肿瘤学会（ASCO）年会即将于5月30日至6月3日在美国芝加哥正式召开。 作为全球肿瘤学领域规模最大、最具影响力的学术盛会之一。近期创新药行业利好可谓密集，多家创新 药企此前已经宣布将在本月底的ASCO大会上披露多项旗下创新管线的重磅临床和研发数据，有望成为 整个创新药产业的短期最强催化。随着此前美宣布降低药价等外部负面因素被持续消化，部分创新药企 业的大额BD交易频出以及龙头企业登陆港股在即等一系列利好刺激下，创新药趋势性价值重估仍然可 期。 港股创新药板块高盈利持续消化估值。港股创新药指数2月21日市盈率为64倍，5月21日最新市盈率仅为 25倍，不足两个月前的一半，当前布局性价比突出。 小而美、高弹性：港股创新药ETF（159567）跟踪国证港股通创新药指数，创新药企业权重90%为全市 场医药主题类指数中最高，有望把握AI赋能创新药研发、国产创新药出海、商业健康保险逐步完善的 创新药利好浪潮。 大而全：创新药ETF（159992）跟踪创新药指数，该指数布局创新药产业链龙头企业，既汇聚全球CXO 龙头企业，又包含国内仿创药企龙头，有望同时受益于AI赋能创新药、国产创新药出海、针 ...

Core Viewpoint - The innovative pharmaceutical sector experienced a significant surge, with multiple companies achieving substantial stock price increases, indicating a positive market sentiment towards domestic innovative drugs and their international expansion opportunities [1][2]. Group 1: Market Performance - On May 21, the innovative drug sector saw a broad increase, with companies like Sanofi Guojian and Shuyou Shen reaching their daily price limits, while others like Saiseng Pharmaceutical and Ruizhi Pharmaceutical rose over 10% [1]. - Specific stock performances included Sanofi Guojian (688336.SS) achieving a price of 47.24 with a 19.99% increase, and Shuyou Shen (300204.SZ) reaching 14.15 with a 20.02% increase [2]. Group 2: International Expansion of Domestic Innovative Drugs - On May 19, Sanofi Guojian and its affiliates granted Pfizer exclusive rights for the development, production, and commercialization of a product, with an upfront payment of $12.5 billion and potential milestone payments up to $4.8 billion [3]. - On May 15, Shiyao Group announced an exclusive licensing agreement with Cipla for the commercialization of a drug in the U.S., with an upfront payment of $15 million and potential total payments nearing $1.1 billion [3]. - Data from Yao Medicine Cube indicated that in 2024, China completed 94 transactions for innovative drug licensing abroad, totaling $51.9 billion, a 26% year-on-year increase [3]. Group 3: Institutional Insights - Following a recent executive order by former U.S. President Trump aimed at lowering drug prices, the impact on China's innovative drug exports is expected to be minimal [4]. - The domestic innovative drug policy is anticipated to undergo significant changes, with 2025 expected to be a pivotal year for policy implementation, including the introduction of a new insurance directory and support for innovative drug pricing mechanisms [5]. - Projections indicate that the net profit for A/H innovative drug companies in 2024 will reach 11.67 billion, a substantial increase from 670 million in 2023, reflecting improved industry profitability [5].