近年来，生物制造已作为多数国家提升经济竞争力的着力点，也是我国继绿色制造、智能制造后，推进制造强国建设的又一重要抓手。同时，各地政府 地区通过结合自身优势力争实现合成生物"研发－转化－产业—集群"协同发展，发挥新质生产力 作用。 8月20-22日 将于 浙江·宁波 举 办 第四届合成生物与绿色生物制造大会 (简称： SynBioCon 2 025 ) 。大会 聚焦" 1+4 " ： AI+生 物智造 这一大热门赛道； 绿色化工与新材料、 未来食品、未来农业和美妆原料四大应用领域 ，邀请国 际领先企业、代表性产业化专家、政府、园 区、资本、协会和联盟等各方共探 "十五五"生物制造产业发展趋势 ； 哪些革新技术和产品将给生物制造产业带来持续的生命力 ； 并致力于 促进科技 成果转移转化 、 产品 规模 化与人才挖掘 。 一、组织机构 主办单位： 宁波德泰中研信息科技有限公司（ DT 新材料） 协办 单位： 宁波酶赛生物工程有限公司 二、大会亮点 三、大会日程 亮点一 ： 大会论坛、闭门活动洞察"十五五"生物制造发展趋势！探索新产品、新技术、新落地、 新合作！ 亮点二： 青年创新技术与价值分享、人才对接与合作！ 亮 ...

项目拟投资3亿，建设综合楼、研发中心、库房、车间、门卫、监控室、消防控制室及相关能源配套系统。项目建成年产3万吨功能性糖醇。 瑞 芬生物作为D-阿洛酮糖-3-差向异构酶在国内 第三家获批 的企业，标志着其在功能性代糖领域的突出技术突破。其突破不仅体现在阿洛酮糖的合 法化生产，更核心的是在酶催化技术这一关键环节实现了自主可控 。 项目进展 | 瑞芬生物 【SynBioCon】 获 悉 ， 近日，内蒙古瑞芬生物科技有限公司 年产3万吨功能糖醇生产基地项目 在相关网站备案公示。 据悉，4月26日,呼和浩特经济技术开发区与北京瑞芬生物科技有限公司签署《瑞芬生物合成生物产业基地项目》合作协议书。此次签约项目总投资约 4亿元，分两期建设年产2万吨糖醇生产基地，一期计划用地120亩，于今年6月开工，2025年11月完成基础建设，2026年3月正式投产。 瑞芬生物创新研发中心(IDEALab)设立于北京，现有3个生产基地，分别位于陕西杨凌、安徽滁州和山东曲阜。 目前滁州基地阿洛酮糖1千吨，待投 产能1万吨，赤藓糖醇产能1.5万吨 。 关于瑞芬生物 成立于2007年，是国家级高新技术企业，始终致力于天然健康食品配料及配料系统的 ...

在 "十四五" 规划收官与 "十五五" 规划谋篇布局的历史节点，我国在生物制造领域的战略布局已然彰显出清晰且鲜明的阶段性演进特质。 那么， "十五五" 规划之下，释放哪些生物制造产业新信号？ 【SynBioCon】 获 悉，近日，赛迪研究院消费品工业研究所在2025赛迪论坛上发布 《"十五五"时期我国生物制造产业发展思路》报告 ，该 报告由赛迪研究院消费品工业研究所所长李博洋分享。 报 告指出，"十五五"是我国生物制造全面崛起的关键时期。其 重要目标 是 先进生物制造产业及相关服务业增加值超4万亿元，生物制造渗透 率达到8% 以上，产业迈向中高端发展 。 "十五五"时期要构建创新+产业+管理服务等三大体系，加快发展 "7+1"生物制造产业体系 ，包括 生物医药、生物基化学品和材料、生物能 源、生物发酵、生物工程食品、生物饲料、生物技术装备和生物服务 。 以下是报告部分内容： 请扫码填写 信息，可下载全部报告 | ▌ 参考信息： 文报告 来 | 本 | 自赛迪研究院 。由 | 作 | 者重新 | 编写，系作者个人观 | | --- | --- | --- | --- | --- | --- | | 点，本平台发 ...

Core Viewpoint - The article emphasizes the importance of biomanufacturing as a key focus for enhancing economic competitiveness in various countries, including China, which is advancing its manufacturing capabilities through initiatives like green manufacturing and intelligent manufacturing [1]. Group 1: Event Overview - The Fourth Synthetic Biology and Green Biomanufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on the integration of AI and biomanufacturing [1]. - The conference aims to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan and identify innovative technologies and products that will sustain the industry's vitality [1]. Group 2: Organizers and Highlights - The conference is organized by Ningbo Detaizhong Research Information Technology Co., Ltd. (DT New Materials) and co-organized by Ningbo Meisai Biological Engineering Co., Ltd. [2]. - Key highlights include forums on biomanufacturing trends, youth innovation sharing, project roadshows, and participation from leading enterprises, top universities, and investment institutions [4]. Group 3: Agenda and Special Activities - The first day features a closed-door high-level seminar focusing on the development trends and growth points of biomanufacturing, with 30 industry leaders and experts invited [7]. - The second and third days will include a macro forum on biomanufacturing, specialized sub-forums on green chemicals, AI in biomanufacturing, future food and agriculture, and beauty raw materials [11]. Group 4: Focus Areas in Sub-forums - Sub-forum topics include the development of bio-based chemicals, green manufacturing technologies for fine chemicals, and the use of non-food raw materials for high-value product development [11]. - AI applications in biomanufacturing will also be discussed, including enzyme discovery and industrial fermentation process control [11].

Core Viewpoint - The article discusses the upcoming SynBioCon 2025 conference, focusing on the research and industrial applications of poly-γ-glutamic acid (γ-PGA), a biopolymer with significant potential in various fields such as functional foods, cosmetics, biomedicine, and biomaterials [1][3]. Summary by Sections γ-PGA Characteristics and Applications - γ-PGA's physiological functions and application areas are highly dependent on the proportion of L-glutamic acid monomers and molecular weight, with low molecular weight γ-PGAs (Mw<500 kDa) suitable for drug delivery and tissue engineering, while high molecular weight γ-PGAs (Mw>1500 kDa) serve as thickeners or flocculants [2]. Industrial Biotechnology Challenges - The efficient biosynthesis of γ-PGA from scratch and the directed synthesis of γ-PGA with varying L-glutamic acid monomer ratios and molecular weights are critical industrial biotechnology challenges that need to be addressed [3]. SynBioCon 2025 Conference Details - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biological manufacturing, as well as advancements and opportunities in green chemicals, new materials, future foods, future agriculture, and cosmetic raw materials [7][8]. - The conference will feature a special session, the "Youth Forum on Biological Manufacturing," aimed at providing insights into scientific issues, solutions, results, scalability, and future directions in the research field [7][8]. Conference Agenda - The agenda includes registration, a closed-door seminar for industry leaders, project roadshows, and various forums covering topics such as green chemicals, new materials, and future foods and agriculture [8][10].

Core Viewpoint - The article discusses the challenges and advancements in the industrialization of natural macromolecular active substances, highlighting a novel bioreactor developed to enhance fermentation processes for these substances [1][2][4]. Group 1: Challenges in Industrialization - Natural macromolecular active substances, such as polyamino acids, functional proteins, and microbial polysaccharides, face extraction difficulties due to their high molecular weight and complex conformations [1]. - The fermentation process of these substances is characterized by high viscosity, high oxygen demand, and high energy consumption, which complicates production [2][4]. - The accumulation of products during fermentation leads to high-viscosity non-Newtonian fluid characteristics, creating barriers that inhibit oxygen and nutrient metabolism, thus limiting yield improvements [1]. Group 2: Innovations in Bioreactor Technology - A new microbubble bioreactor platform has been developed using laser sintering 3D printing technology and computational fluid dynamics principles, aimed at overcoming the challenges of high-viscosity fermentation processes [2][4]. - This bioreactor design allows for the transition from macro to micro bubbles (less than 100 μm), significantly increasing the contact surface area between microorganisms and oxygen, thereby enhancing oxygen transfer efficiency by 120%-135% [4]. - The energy efficiency of the fermentation process is improved by 1.6 to 2.9 times compared to traditional bioreactors [4]. Group 3: Performance Improvements in Fermentation - The new bioreactor technology has been validated in a 7 L fermentation tank for the production of γ-polyglutamic acid (γ-PGA), achieving over a 40% increase in yield [5]. - The technology has also demonstrated versatility, with fermentation yields for other macromolecules such as mussel adhesive protein, panibacterial polysaccharide, welan gum, β-glucan, and ε-polylysine increasing by 79%, 58%, 39%, 50%, and 43% respectively [5]. Group 4: Implications for the Industry - This innovative research provides a reference and technical support for the efficient biosynthesis and industrial application of macromolecular active substances, as well as insights for enhancing fermentation processes in other synthetic biology products [7]. - The advancements in biomanufacturing are expected to contribute to the ongoing development of the synthetic biology industry, particularly in the context of green manufacturing and sustainable practices [7].

Core Insights - The article discusses the launch of the "Synthetic Human Genome Project" (SynHG), led by Professor Jason Chin from the University of Oxford, with funding of £10 million from the Wellcome Trust, aiming to chemically synthesize a complete human genome [1][2] - The project is expected to develop foundational tools and methods that will support future research in synthetic biology, potentially leading to new discoveries about how cells utilize their genomes [2][3] Group 1: Project Overview - SynHG is the first of its kind globally, with a goal to construct a complete human genome through chemical synthesis [1] - The project aims to establish a technical framework within five years and to synthesize a complete human chromosome within 5-10 years, facing significant scientific challenges [2] Group 2: Scientific Implications - Professor Jason Chin emphasizes that the ability to synthesize large genomes could fundamentally change the understanding of genomic biology and expand the capabilities of biotechnology and medicine [3] - The project is not about creating life but focuses on understanding gene expression regulation mechanisms [3] Group 3: Future Directions and Events - The upcoming "Synthetic Biology and Green Bio-Manufacturing Conference" (SynBioCon 2025) will take place from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and bio-manufacturing [4][5] - The conference will explore trends in bio-manufacturing, innovative technologies, and the potential for technology transfer and talent acquisition in the industry [4]

SynBioCon 大会 | 致力于科技成果转化 第四届合成生物与绿色生物制造大会 (简称：SynBioCon 2025) 将于 8月20-22日 在 浙江·宁波 举办，由DT新材料主办，酶赛生物协办，中国 生物工程学会生物基材料专业委员会、上海市未来产业生物制造专委会、广州合成生物产学研技术创新联盟共同支持 。 DT新材料致力于科技成果转移转化。SynBioCon大会聚焦产业生态发展与科技成果转移转化，已完成1000+次科研院所和初创项目对接。本届大会 同期将继续举办 特色活动 「合成生物制造创新科技成果展示与对接 」 ， 收集并 展示100个0~100的合成生物制造创新科技成果 ， 以 促进行 业高效科技成果与转化。 SynBioCon大会持续发布科技成果。本期介绍项目如下： 成果简介 L-哌啶甲酸，简称L-PA，是一种重要的刚性环状非蛋白质氨基酸，广泛用于罗哌卡因等手性药物和雷帕霉素等生物活性物质的制备。近来发现可作 为植物刺激素，激活植物免疫。 本技术利用先进代谢工程技术，通过从头设计合成路径和系统、优化大肠杆菌，构建了第一代生产哌啶甲酸的大肠杆菌细胞工厂，含IPTG诱导质粒， 遗传稳定，以赖氨酸无机 ...

SynBioCon 大会 | 同舟纵横 集"膜材料生产---工艺研发及装备制造---工艺设计---技术服务"为一体的物料分离全产业链企业—— 同舟纵横 将出席 2025年8月20-22日，浙江·宁波 举办的 SynBioCon 2025 第四届合成生物与绿色生物制造大会 同舟纵横 已入驻 全球生物基和生物制造产业服务 平台-新品库（ bio-basedlink ） 。 同舟纵横新品库网址 ： https://www.bio-basedlink.net/index/brand/brand_show/article_id/193.html ↓↓↓ 公司介绍 同舟纵横 (厦门)流体技术有限公司专注于工 业流体领域的分离纯化，是一家集材料生产 -工艺 研发 ---设备制造--药剂生产-EPC设计及工程总包为 一体的 国家级高新技术企业和国家级专精特新小巨 人企业。 多年来同舟纵横不断探索已经完成了数百工程 项目，涉及医药、化工、食品添加剂、淀粉糖、生 物发酵、植物提取、新能源、环保等各个领域， 在 实 战中公司积累了大量的工程经验，树立了良好的 行业口碑，已经成为了利用压力驱动膜技术板块、 电驱动膜技术板块和连续离交 ...

三方共建的AI4S研发平台将 聚焦基因线路设计、酶的挖掘与优化、代谢途径挖掘、合成生物学大数据分析、人工细胞工厂创制及生物医药合成等六大 研究方向 ，重点突破基因组设计和优化、酶分子改造等关键核心技术，覆盖生物医药、生物农业、环保科技等战略性新兴产业领域。 值得一提的是，研发平台将全力构建合成生物学AI模拟与实验验证一体化平台，深度融合高性能计算、机器学习与实验数据，实现 "理性设计→智能进 化"的高效协同 。 例如，将AI技术与自动化实验设备有机结合，利用机器人操作和自动化液体处理系统等，实现高通量的精准实验操作和数据采集。研发平台还将服务于 虚拟筛选与实验验证协同、细胞工厂模型建立、疾病模型预测等 相关产品的研发全链条。 01 我国已布局多家合成生物智能化平台 截止目前，国内已有多个高校和研究机构布局类似平台，主要包括： 1 、中国科学院深圳先进技术研究院（合成生物学研究所） 底层技术&AI | 安徽师范、中科大、芜湖市 【SynBioCon】 获 悉 ， 6月28日，安徽师范大学与中国科学技术大学、芜湖市弋江区共建的"合成生物智能 研发平台（AI4S）"建设启动仪式在芜 湖举行。 据悉，研发平台已与芜湖 ...