Expansion of potential treatment applications of deucrictibant in people living with bradykinin-mediated angioedemaZUG, Switzerland, May 12, 2025 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to help address unmet needs of those living with bradykinin-mediated diseases such as hereditary angioedema (HAE), including HAE with normal C1 inhibitor and acquired angioedema due to C1 inhibitor deficiency (AAE-C1INH), t ...

Core Insights - The International Guillain-Barré Syndrome Outcomes Study (IGOS) presented real-world evidence showing improved outcomes with tanruprubart compared to current standards of care in matched patient populations [1][2] - Tanruprubart, a first-in-kind monoclonal antibody, is designed to block C1q to halt neuroinflammation and nerve damage in Guillain-Barré Syndrome (GBS) [2][3] - The drug has received Fast Track and Orphan Drug designations from the U.S. FDA and the European Medicines Agency for GBS treatment [5] Company Overview - Annexon, Inc. is focused on developing novel therapies for classical complement-mediated neuroinflammatory diseases affecting the body, brain, and eye [1][7] - The company aims to deliver innovative treatments targeting C1q to prevent tissue damage and loss in various neuroinflammatory conditions [7] - Annexon's pipeline includes investigational drug candidates addressing unmet needs in autoimmune, neurodegenerative, and ophthalmic diseases, potentially benefiting over 8 million people globally [7] Industry Context - GBS is a rare autoimmune disease with no FDA-approved therapies, characterized by rapid progression and severe weakness, often leading to paralysis [2][6] - The disease results in over 22,000 hospitalizations annually in the U.S. and Europe, contributing to significant morbidity and economic costs to the healthcare system [6] - The long-term burden of GBS has led to a multi-billion-dollar annual economic impact on the U.S. healthcare system [6]

Core Viewpoint - PyroGenesis Inc. is set to host a conference call on May 14, 2025, to discuss its financial results for Q1 2025 and provide updates on company progress and developments [1]. Company Overview - PyroGenesis is a high-tech company specializing in advanced all-electric plasma processes and sustainable solutions aimed at supporting heavy industries in energy transition, emission reduction, commodity security, and waste remediation [1][3]. - The company has developed proprietary and patented plasma technologies that are being adopted by major industry players in four key markets: iron ore pelletization, aluminum, waste management, and additive manufacturing [3]. - PyroGenesis operates from its Montreal office and has manufacturing facilities of 3,800 m² and 2,940 m², maintaining a competitive edge through continuous technology development and commercialization [3]. - The company is ISO 9001:2015 and AS9100D certified, having been ISO certified since 1997 [3]. - PyroGenesis' shares are publicly traded on the TSX (TSX: PYR), OTCQX (OTCQX: PYRGF), and Frankfurt Stock Exchange (FRA: 8PY1) [3].

Company Overview - Sohu.com Limited (NASDAQ: SOHU) is a leading Chinese online media platform and game business group, established by Dr. Charles Zhang in the 1990s [3] - The company operates a comprehensive matrix of Chinese language web properties, including Sohu News App, Sohu Video App, mobile portal m.sohu.com, PC portal www.sohu.com, and online games platform www.changyou.com/en/ [3] Business Operations - Sohu provides a vast array of content such as news, information, text, pictures, videos, and live broadcasting, making it indispensable to the daily life of millions of Chinese users [4] - The online game business is conducted through its subsidiary Changyou, which develops and operates a diverse portfolio of PC and mobile games, including the well-known Tian Long Ba Bu ("TLBB") [4] Financial Reporting - Sohu will report its first quarter 2025 unaudited financial results on May 19, 2025, before U.S. market hours [1] - A conference call hosted by Sohu's management team will take place on the same day at 7:30 a.m. U.S. Eastern Time [1]

Financial Data and Key Metrics Changes - The company reported first quarter revenue of $109.3 million, representing a year-over-year growth of 13% [7][27] - Non-GAAP operating margin reached a record 11.5%, up over 500 basis points from the previous year [26][29] - Non-GAAP free cash flow was $19.5 million, an increase of 72% year-over-year [26][27] - Remaining performance obligations (RPO) totaled $360.2 million, up 24% year-over-year [28] Business Line Data and Key Metrics Changes - Subscription revenue was $108.7 million, also reflecting a 13% year-over-year growth [27] - The number of customers contributing more than $50,000 in annual recurring revenue (ARR) grew by 22% year-over-year [27] - Average contract value (ACV) for Q1 was $14,961, up 16% year-over-year [28] Market Data and Key Metrics Changes - The company noted a shift in consumer behavior, with 46% of Gen Z preferring social media over traditional search engines for brand discovery [10][11] - The enterprise customer cohort saw a 22% growth, indicating strong demand in the market [7] Company Strategy and Development Direction - The company aims to expand its sales capacity and pipeline generation, particularly focusing on enterprise customers [8][9] - Key growth drivers include winning enterprise accounts, enhancing customer health and adoption, expanding partnerships, and improving account penetration [14][24] - The rebranding of the influencer marketing platform aims to enhance brand engagement and ROI [12][18] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the enterprise pipeline generation despite elongated procurement processes [9][30] - The company does not expect significant changes in the demand environment for fiscal year 2025 compared to the previous year [29][30] - Management highlighted the importance of social media for customer engagement and brand reputation [35][86] Other Important Information - The company launched significant enhancements to its influencer marketing product, including AI-powered features [12][17] - The integration with Salesforce's AgentForce is expected to enhance customer engagement and pipeline opportunities [61] Q&A Session Summary Question: Insights on enterprise wins and pipeline - Management noted a variety of industry verticals in enterprise wins, indicating healthy pipeline creation [32][34] Question: Pipeline coverage ratios for 2025 - Management expressed confidence in pipeline hygiene and metrics, with no material changes observed in the macro environment [45][46] Question: CRPO growth and gross retention - Management confirmed strong CRPO growth of over 21% and noted improvements in gross retention across customer segments [50][51] Question: Profitability and full-year investment philosophy - The revenue overperformance and back-end loaded hiring contributed to the profitability beat, with flexibility maintained for potential risks [54][56] Question: Impact of AgentForce integration on pipeline - Management indicated that it is early to assess the full impact of the AgentForce integration on pipeline trends [60][62] Question: Q2 revenue guidance and deferred revenue - Management explained that the Q2 guidance reflects a measured approach, with deferred revenue impacted by large deals signed in Q4 [66][67] Question: Cross-sell platform expansion - Management highlighted the importance of cross-selling and noted healthy trends in penetration rates for existing customers [70][72] Question: State of the sales organization - Management confirmed an increase in sales capacity and expressed confidence in the stability and focus of the sales organization [76][80] Question: Sales cycles and macroeconomic impacts - Management stated that there are currently no material changes in sales cycles, emphasizing the mission-critical nature of their product [84][86]

TKO Group Holdings (TKO) Q1 2025 Earnings Call May 08, 2025 05:00 PM ET Speaker0 Good afternoon. Thank you for attending today's TKO Q1 twenty twenty five Earnings Call. My name is Cole, and I'll be the moderator for today's call. All lines will be muted during the presentation portion of the call with an opportunity for questions and answers at the end. I'd now like to hand it over to Seth Zaslow, Head of Investor Relations. Please go ahead. Speaker1 Good afternoon, and welcome to TKO's first quarter twent ...

Sprout Social (SPT) Q1 2025 Earnings Call May 08, 2025 05:00 PM ET Speaker0 Ladies and gentlemen, this is the operator. Today's call is scheduled to begin momentarily. Until that time, your lines will be placed on music hold. Thank you for your patience. Thank you for standing by. My name is Kate, and I will be your conference operator today. At this time, I would like to welcome everyone to the Sprout Social First Quarter twenty twenty five Earnings Call. All lines have been placed on mute to prevent any b ...

Core Viewpoint - Paramount Global anticipates the merger with Skydance Media to close in the first half of 2025, pending regulatory approvals from the FCC [1][2][3] Financial Performance - Q1 revenue decreased by 6% to $7.2 billion, but increased by 2% when excluding the impact of Super Bowl LVIII from the previous year [4] - The company reported a net profit of $152 million, a significant recovery from a loss of $554 million in the same quarter last year [5] - Adjusted EPS was 29 cents per share [5] - Streaming revenue rose by 9% to over $2 billion, with Paramount+ contributing to a 16% increase in subscription revenue [6] Subscriber Growth - Paramount+ added 1.5 million net new subscribers, reaching a total of 79 million by the end of March [7] - The growth was driven by series, post-theatrical releases, CBS primetime, and sports programming [7] Advertising and Media Performance - Ad sales fell by 9%, with 8% attributed to Super Bowl comparisons [6] - CBS is expected to be the most-watched network in primetime for the 17th consecutive season, despite a 21% decline in ad revenue [8] Division Performance - TV Media operating profit decreased by 36% to $922 million on revenue of $4.54 billion [9] - Filmed entertainment revenue increased by 4%, with theatrical revenue easing by 3% [9] - The success of Sonic the Hedgehog 3 contributed to a profit swing in the division, moving from a $3 million loss to a $20 million profit [10]

Perma-Fix Environmental Services (PESI) Q1 2025 Earnings Call May 08, 2025 10:00 AM ET Speaker0 Good morning, everyone, and welcome to the Perma Fix Fiscal First Quarter twenty twenty five Earnings Please note this conference is being recorded. I will now turn the conference over to your host David Waldman of Crescendo Communications. David, the floor is yours. Speaker1 Thank you, Jenny, and good morning, everyone. Welcome to Permafix Environmental Services First Quarter twenty twenty five Conference Call. ...

Financial Data and Key Metrics Changes - In Q1 2025, total net revenue decreased by 1% year over year to $98.7 million, within the guidance range of $98 million to $100 million [18] - Adjusted EBITDA increased by 3.5% year over year to $18.1 million, exceeding the guidance range of $17 million to $18 million [18] - Adjusted EBITDA margins expanded from 17.6% in Q1 2024 to 18.4% in Q1 2025 [18] Business Line Data and Key Metrics Changes - Digital revenue grew by 6% year over year, accounting for 57% of total net revenue in Q1 2025, the highest percentage achieved by the company [6][7] - Townsquare Ignite, the digital advertising segment, reported a net revenue increase of 7.6% year over year, with a profit margin of 21.5% [19] - Townsquare Interactive, the subscription-based digital marketing solutions segment, saw a segment profit increase of 22% year over year, with profit margins at approximately 32% [20] Market Data and Key Metrics Changes - The broadcast advertising net revenue, excluding political, declined by 8.3% year over year, while total broadcast revenue decreased by 9.1% [21] - The company continues to gain local and national broadcast market share, despite the overall decline in the broadcast market [16] Company Strategy and Development Direction - The company reaffirms its digital-first local media strategy, focusing on markets outside the top 50 in the U.S. as a competitive advantage [29] - The media partnership strategy is expected to generate $50 million in revenue within three to five years, contributing to the company's growth without significant capital investment [10][49] - The company plans to continue investing in digital product technology, sales, and content to maintain its competitive edge [24] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate macroeconomic uncertainties and highlighted the strength of its digital platform as a growth engine [4][30] - The company anticipates continued growth in digital advertising revenue, with Q2 growth rates expected in the mid-single digits [10][25] - Management noted that the broadcast segment is viewed as a mature cash cow business, with expectations of continued revenue decline [15] Other Important Information - The company ended Q1 2025 with $6 million in cash, down from $27 million at year-end, primarily due to interest payments and refinancing fees [23] - The board approved a quarterly dividend of $0.20 per share, reflecting a yield of approximately 11.5% based on the current share price [25] Q&A Session Summary Question: Can you discuss the competitive landscape for Ignite and revenue from markets without radio stations? - Management highlighted that operating outside the top 50 markets provides a significant competitive advantage, with Ignite being a full-service digital agency [35][36] Question: What percentage of broadcast advertisers also buy digital solutions? - The majority of broadcast advertisers also purchase digital solutions, with over 85% engaging in both [40][43] Question: How does the company view potential deregulation in the broadcast industry? - Management is optimistic about deregulation, seeing it as an opportunity for both organic growth and potential acquisitions [46][49] Question: What is the growth potential for media partnerships outside the top 50 markets? - Management indicated significant growth potential, with hundreds of markets available for partnerships, contributing to future revenue growth [56][58] Question: How are interactive subscribers responding to current economic uncertainties? - Management noted a temporary pause in spending due to uncertainty, but recent months have shown improvement in revenue trends [60][64]