On Thursday, Tyra Biosciences, Inc. TYRA released clinical proof-of-concept data for TYRA-300 in patients with metastatic urothelial (mUC) cancer from its ongoing SURF301 Phase 1/2 study. These data will be presented at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. TYRA-300 is a potential first-in-class, investigational, oral, FGFR3-selective inhibitor designed to avoid the toxicities associated with the inhibition of FGFR1, FGFR2, and FGFR4 while being agnostic for the FGFR3 ga ...

Fulcrum Therapeutics (FULC) , a clinical-stage company, is expected to report third-quarter 2024 results early next month. The Zacks Consensus Estimate for the to-be-reported quarter's loss is pinned at 40 cents per share. The company currently does not have any marketed products and does not record any revenues. The Zacks Consensus Estimate for Fulcrum's loss per share has narrowed from 46 cents to 28 cents for 2024 over the past 60 days, while that for 2025 has narrowed from $1.51 to $1.14. FULC Estimate ...

Bed Bath & Beyond's owner said in a regulatory filing that it will cut one-fifth of its workforce.Beyond, Inc., formerly known as Overstock, bought the BB&B brand after the original went bankrupt.As an online-only retailer, the company says the cuts will support its "affinity and data monetization model." Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. Read preview Thanks for signing up! Go to newsletter preferences Thanks for signing up! ...

WARREN, N.J., Oct. 18, 2024 (GLOBE NEWSWIRE) -- Tevogen Bio ("Tevogen" or "Tevogen Bio Holdings Inc.") (Nasdaq: TVGN) is a clinical-stage specialty immunotherapy biotech developing off-the-shelf, genetically unmodified T cell therapeutics to treat infectious disease and cancers. Since being founded in 2020, Tevogen Bio has taken a unique approach to both drug development and managing its business operations. The company launched is proprietary ExacTcell™ technology, designed to create accessible and disease ...

BofA Securities has upgraded Tyra Biosciences TYRA, a clinical-stage biotechnology company focused on developing next-generation precision medicines. The company's initial focus is on improving small molecule drug discovery and development in targeted oncology and genetically defined conditions. The company has a pipeline of four preclinical candidates. In July, Tyra Biosciences announced preclinical proof-of-concept results with TYRA-300 in hypochondroplasia (HCH), the most common form of dwarfism. TYRA-30 ...

The federal government is investigating Tesla's "Full Self-Driving" software after several crashes that were blamed on the system, including one that led to a fatality. The National Highway Traffic Safety Administration on Friday said it was opening an investigation into 2.4 million Tesla vehicles with the automaker's Full Self-Driving software after four reported collisions. The US auto safety regulator said it was opening the preliminary evaluation after four reports of crashes where FSD was engaged durin ...

As Amazon looks to add more automation into its supermarkets, the retailing giant is partnering with a Khosla-backed startup that just came out of stealth last year, CNBC has learned.Last week, Amazon announced it's piloting a new concept at one of its Whole Foods locations in a Philadelphia suburb, where a micro-fulfillment center will be bolted onto the store and allow shoppers to purchase staples not typically stocked by the organic grocer.The facility relies on warehouse automation technology from Fulfi ...

Chipotle's Investment Strategy - Chipotle announced a minority investment in Lumachain and Brassica through its $100 million Cultivate Next venture fund, aimed at supporting companies aligned with its mission to "Cultivate a Better World" and accelerate its growth plans to operate 7,000 restaurants in North America [1] - The Cultivate Next fund, introduced in 2022, focuses on early-stage investments in strategically aligned companies to enhance Chipotle's long-term growth and sustainability goals [1] Lumachain Overview - Lumachain, headquartered in Sydney, Australia, is a minority female-founded company that uses Computer Vision-based AI to improve food production safety, yield, efficiency, quality, traceability, and trust [2][3] - The company's SaaS platform provides real-time tracking of the origin, location, and condition of individual items in the supply chain, reducing waste and increasing efficiency [3] - Lumachain's AI platform also monitors operations inside food production plants to enhance quality, efficiency, and safety [3] Brassica Overview - Brassica is a fast-casual restaurant based in Columbus, Ohio, offering Eastern Mediterranean-inspired cuisine with a focus on wholesome, locally-sourced ingredients [4] - Founded in 2015, Brassica operates six locations and provides a personalized dining experience with signature items like house-made falafel, organic pita, and antibiotic-free meats [4] - The restaurant emphasizes healthy dining options without compromising flavor, featuring a welcoming atmosphere with natural materials and standout architectural details [4] Strategic Alignment with Chipotle - Chipotle's investment in Brassica aligns with its commitment to using real, fresh ingredients and creating craveable food, supporting Brassica's expansion to new markets and locations [5] - The Cultivate Next venture fund portfolio includes other companies like GreenField Robotics, Hyphen, Local Line, Meati Foods, Nitricity, Vebu, and Zero Acre Farms, all contributing to Chipotle's mission of sustainability and innovation [5] Chipotle's Market Position - Chipotle operates over 3,500 restaurants globally as of June 30, 2024, and is the only restaurant company of its size that owns and operates all its locations in North America and Europe [6] - The company is recognized on Fortune's Most Admired Companies 2024 list and Time Magazine's Most Influential Companies, with over 120,000 employees dedicated to providing a great guest experience [6] - Chipotle continues to lead in digital, technology, and sustainable business practices, making its food more accessible while maintaining its commitment to real, fresh ingredients [6]

After a decade of unfulfilled promises about driverless vehicles, Tesla CEO Elon Musk hyped the company's Cybercab concept on Thursday night, showing off a low, silver two-seater with no steering wheels or pedals.Rolling up to the stage in a Cybercab almost an hour after the company's "We, Robot" event was supposed to begin, Musk said the company had 21 of these vehicles, and a total of 50 "autonomous" cars on-location at the Warner Bros. studio in Burbank, California where Tesla hosted its invitation-only ...

Core Insights - Sally Beauty Holdings, Inc. (SBH) is navigating a mix of opportunities and challenges in the beauty retail industry, focusing on strategic growth pillars to drive performance amidst weak consumer sentiment and rising costs [1][9][11] Strategic Growth Initiatives - SBH is centered around three key initiatives: enhancing customer-centricity, expanding high-margin brands, and driving innovation, with recent product launches resonating well with consumers [3][4] - The company’s store optimization program has improved productivity and profitability, contributing to a seamless omnichannel experience [4] - The Fuel for Growth plan is expected to deliver cumulative benefits of $120 million by 2026, enhancing margins and operational efficiency [4] Customer-Centric Strategies - SBH is acquiring new customers through marketing programs and strategic partnerships with major retailers like Amazon and Walmart, which are driving incremental sales [5][6] - The loyalty program is significant, with 78% of U.S. and Canadian sales coming from loyalty members in the fiscal third quarter [6] - The introduction of the Studio by Sally concept aims to provide a digital-first, DIY-centric shopping experience [6] New Retail Concepts - The launch of the Happy Beauty Co. concept targets value-conscious consumers with products priced under $10, showing positive reception in pilot locations [8] Challenges Facing the Company - SBH is experiencing challenges from weak consumer sentiment, with comparable transactions in the Sally Beauty Supply segment declining by 3% in the fiscal third quarter [9] - Rising operational costs, particularly in SG&A expenses, are squeezing margins, with adjusted EBITDA down 1.7% year-over-year and a quarterly adjusted EBITDA margin of 12.4% [10] - Currency fluctuations are also impacting international sales, complicating financial performance [10]