如果您怀孕了或者正准备怀孕，您需要了解以下关于使用 GLP-1 药物治疗 2 型糖尿病或肥胖症的信息。 胰高血糖素样肽 1 (GLP-1) 受体激动剂，如 Ozempic (semaglutide) 和 Trulicity (dulaglutide)，越来越多地用于治疗 2 型糖尿病，在某些情况 下，还用于减肥。如果您患有 2 型糖尿病，您的医生甚至可能提到过尝试其中一种较新的药物。 但是，如果您怀孕或试图怀孕，这些药物可以 安全使用吗？ 整理 | GLP1减重宝典内容团队 研究人员发现，与母亲在怀孕期间注射胰岛素控制糖尿病相比，母亲使用 GLP-1 药物所生的孩子患先天性缺陷的风险并没有增加。 虽然研究 结果令人鼓舞，但研究人员指出，还需要更多的证据才能排除 GLP-1 对胎儿的潜在风险，而且他们的研究只是迈出了了解这些药物如何影响儿 童发育的第一步。 在另一项于2023 年发表在《内分泌学前沿》上的研究中，研究人员回顾了 39 项独立研究，这些研究考察了 GLP-1 激动剂和另一种用于治疗 2 型糖尿病和体重管理的药物（称为SGLT2 抑制剂）在怀孕和哺乳期间对后代结果的影响。研究发现， GLP-1 的使 ...

Core Viewpoint - The letter emphasizes the importance of identifying and holding the best businesses in a city, focusing on a few certainty opportunities for long-term investment success [2][3]. Summary by Sections Investment Strategy - The strategy involves concentrating on a limited number of high-quality businesses and low-valued assets, with the belief that fewer, well-chosen investments lead to better outcomes [4][10]. - The current market is characterized by significant volatility and structural opportunities, particularly in new consumption and innovative pharmaceuticals [3]. Market Observations - The stock market is divided between high-growth sectors like new consumption and innovative drugs, and a majority of companies that remain undervalued and face strong competition [4]. - The shift from a unipolar to a multipolar world is expected to provide additional rewards for Chinese assets as they gain equal footing globally [2][10]. Key Investment Areas - The portfolio includes several promising sectors: 1. Major entertainment and social platforms evolving towards AI agents [5]. 2. Companies with strong pricing power in advanced chip design [6]. 3. Firms possessing scarce copper and gold resources amid a weakening dollar trend [7]. 4. Leading AI models and public cloud services essential for businesses utilizing AI [8]. 5. Brands focused on sports and outdoor lifestyles, showing significant improvements in supply chain and brand management [9]. Market Dynamics - The Hong Kong market has emerged as a leading venue for IPO financing, signaling a shift in international capital's perception of Chinese assets [10]. - The influx of capital into Hong Kong is contributing to a vibrant and prosperous market environment [10].

Core Insights - The article emphasizes the need to understand evolving consumer behaviors in the context of macroeconomic uncertainties, inflation, geopolitical tensions, and technological disruptions, highlighting a shift from pandemic-induced consumption to a new stable norm [1] Group 1: Changes in Consumer Behavior - Consumers are spending more time alone online, with nearly 90% of the additional 3 hours per week in the U.S. dedicated to solitary online activities, leading to a decline in face-to-face social interactions [2][3] - In China, there is a dual focus on family and social relationships while "self-consumption" trends are rising, with categories like personal care and home entertainment becoming dominant [2][3] Group 2: Trust Dynamics - Despite high usage of social platforms, consumers exhibit low trust in these platforms for purchase recommendations, preferring advice from friends, family, and verified reviews [4][5] - Brands must shift from traditional advertising to building trust through authentic word-of-mouth and verifiable social content, as the context of who says what is more critical than the message itself [5] Group 3: Gen Z Consumer Trends - Gen Z is now a dominant consumer group, characterized by financial fragility yet a willingness to spend on self-expression and social currency, particularly in beauty, fashion, and wellness sectors [6][7] - This generation seeks brands that resonate with their values and cultural identities, emphasizing the need for brands to align with their ideals rather than merely adopting a youthful image [8] Group 4: Local Brand Preference - There is a significant shift towards local brands, with 47% of consumers preferring them, especially in food, beauty, and daily consumer goods, driven by a desire for familiarity and trust amid global uncertainties [9] - The rise of local brands in China reflects deeper cultural connections and a response to geopolitical tensions, indicating that global brands must localize their strategies to remain relevant [9] Group 5: Value Calculation Changes - Consumers are becoming more strategic in their spending, often trading off between categories, with over 79% engaging in "non-linear downgrading" to justify purchases in non-essential categories [11] - In China, the trend of "self-care" post-pandemic indicates that consumers are not just looking for discounts but for rationalizations of their spending, focusing on emotional and identity-driven purchases [11] Conclusion - The article concludes that understanding the complexities of human behavior is crucial for brands in navigating the evolving consumer landscape, emphasizing the importance of emotional resonance and genuine connections over mere transactional relationships [12][13]

Core Perspective - The transformation of Bear Electric (002959) from a small appliance manufacturer to a lifestyle brand exemplifies a significant shift in consumer demand from product functionality to experiential living [1][7] Group 1: Brand Transformation - Bear Electric's shift involves a comprehensive redefinition of brand value, focusing on providing complete lifestyle solutions rather than isolated product functionalities [2] - The company emphasizes user-centric solutions, moving from merely selling appliances to offering integrated experiences that fulfill broader lifestyle needs [3][4] Group 2: Product Innovation - The introduction of eight scenario-based solutions at AWE, such as the "Vital Breakfast" and "Exquisite Care," illustrates Bear Electric's commitment to creating convenient and enjoyable user experiences [3] - The company has developed a range of products that address various daily needs, allowing users to manage tasks efficiently and focus on enjoying life [4] Group 3: Research and Development - Bear Electric has established an agile system that connects user insights directly to product development, enhancing innovation and responsiveness to consumer needs [5][6] - The company boasts a robust R&D team of nearly 600 professionals, with significant investments in innovation, including a 36.48% year-on-year increase in R&D expenditure for 2024 [6] Group 4: Competitive Advantage - The transition to a lifestyle brand highlights that true competitive strength lies in understanding and integrating into consumer lifestyles, rather than merely relying on scale or cost advantages [7]

Core Insights - The article discusses the decline of popular bookstores in China, highlighting the shift from traditional book selling to lifestyle branding and the challenges faced by these establishments in maintaining profitability and relevance [2][4][10] Group 1: Decline of Popular Bookstores - Notable bookstore brands, including Tsutaya Bookstore, have closed multiple locations in China, reflecting a broader trend of well-known bookstores shutting down or exiting the market [2][4] - From early 2024 to April 2025, at least seven prominent bookstore brands are expected to close or withdraw from the market, with the total number of closures exceeding 50 across major cities [2][4][10] Group 2: Changing Consumer Behavior - Many consumers visit bookstores primarily for social media photo opportunities rather than purchasing books, leading to a disconnect between foot traffic and actual sales [4][10][16] - The shift in reading habits, exacerbated by the pandemic, has led to a preference for online book purchases, with physical bookstores capturing only 13.99% of the retail market in 2024 [4][10] Group 3: Business Model Transformation - Bookstores have increasingly relied on non-book sales, with only 30% of overall sales coming from book sales, while 70% is generated from food and beverage offerings [5][10] - The concept of "book+" has emerged, where bookstores aim to create a lifestyle experience rather than solely focusing on book sales [5][10][21] Group 4: Community Engagement and Sustainability - Successful bookstores are those that establish strong connections with their local communities, offering events and activities that resonate with residents [22][24] - Some independent bookstores are thriving by focusing on their core function of promoting reading and providing a welcoming environment, contrasting with the flashy, high-cost models of popular bookstores [22][24][25]

Group 1 - The popularity of the Jiangsu Province Urban Football League ("Su Super") is rising, with ticket demand exceeding supply ratios of over 10:1 and even 30:1 for some matches [1] - Weivi Co., Ltd. (600300), the naming sponsor for the Xuzhou division of "Su Super," has seen a significant increase in visibility, with a 175% year-on-year growth in Baidu search index over the past three months [1] - Weivi Co., Ltd. aligns its brand mission of promoting health and happiness with the growing value of football as a symbol of a healthy lifestyle, beyond just competitive sports [1] Group 2 - The "Su Super" event, characterized by its grassroots appeal and a philosophy of "joy first, competition second," has attracted numerous fans, creating a vibrant and energetic atmosphere [2] - By sponsoring "Su Super," Weivi Co., Ltd. effectively reaches young consumers, conveying its brand philosophy and product information [2] - The deep brand heritage and extensive market influence of Weivi Co., Ltd. enhance the cultural significance of the "Su Super" event, thereby increasing its brand value [2]

说到"可持续"，很多人觉得就是绿色环保、少用塑料、骑车上班等——这些当然重要，但对创业者们而言，他 们既是频繁差旅的"高碳足迹人群"，又是企业员工效仿的"文化塑造者"，这样的"双重身份"下，"可持续"的含义 便不仅是绿色环保，还有对个人身体、心理以及对企业与社会的长期发展影响的一种生活方式。 这就像你在经营两家公司：一家叫"Startup Inc."，另一家叫"Yourself Ltd."。前者靠经营和管理来维系；后者则依 赖你的身体、情绪、时间配置等。如果"Yourself Ltd."出现经营不善，哪怕"Startup Inc."再风光，也会隐患重重。 所以，创业者要找到自己的"可持续生活方式"。 可持续是一种生活方式的美学 在全球范围内，无论是个人还是社区，推动可持续生活方式的努力层出不穷。主流体系下,以下实践与体现 比较常见： 1. 极简主义（ Minimalism）： 舍弃不必要的物品，只保留那些真正重要和有价值的东西，从而实现身心的 轻松与自由，带来了更多的内心平静和满足感。它主张"少即是多"的理念，将生活简化到最本质的状态。 2. 数字极简主义（Digital Minimalism）： 减少对电子 ...

随着人们对生活方式的追求已逐渐超越物质层面的满足，产品维度不再是简单的物理空间，能激发"情 绪共鸣"，为愉悦而买单正成为全新趋势潮流。 愉悦自己的生活哲学 进入耀胜新世界，就像进入了一个全新的故事里，而有序地经过耀胜新世界的各个部分，就像电影里的 连续情节，这些部分一起组成了一个故事。 首先，耀胜新世界同时拥有商业、写字楼、住宅三种业态，全业态共融共生，打破了传统生活的边界， 实现了"下楼即繁华，归家即静谧" 的完美平衡，于繁华与烟火之上，又兼具自然与舒适。 其赋予约8万方K11 Select「未来生活+」定位，规划了各有特色的四大主题露台公园，创新引入宠物友 好设施，打造番禺首个宠物友好型购物中心，侧重年轻化、潮流化，以及创意的多元碰撞，可自由地体 验潮流艺术创意，相比一座年轻化商业综合体，它更像一座社区后花园，因为业主只需电梯下楼，便能 直达商场。 K11 Select作为藏在家楼下的高端时尚"微度假"地标，回家前都可以去溜达一圈，逛逛艺术展，感受繁 华生活里的艺术与生活碰撞； 除此之外，都市与自然相融合，与约3万方园艺广场相辉映，六维立体园林移步易景，耀胜尊府引入大 量季相植物点缀，春观花，秋结果，一年 ...

Core Viewpoint - The article highlights the various community and sustainability initiatives organized by the Xinghuan International Commercial Center, aiming to enhance public engagement and promote a harmonious relationship between people and nature [1][2]. Group 1: Community Engagement Initiatives - The "Soul Market" event at Xinghuan attracted many families, focusing on sustainable living through ecological farming and traditional techniques, allowing children to learn about agriculture [1]. - The "Xing Market" promotes opportunities for the public to engage with sustainable lifestyles and charitable activities, including a "Swap Goods" initiative to encourage recycling [1]. - The center collaborates with organizations like Whale Conservation and others to support marine conservation and care for special populations, bridging the gap between local culture, environmental protection, and charity [1]. Group 2: Cultural and Historical Integration - The "Xinghe Wandering" area juxtaposes the modern Xinghuan with the historical Wuxian Gate Power Plant site, fostering a dialogue between old and new, while preserving the original planning characteristics of the Haizhu Square area [2]. - Xinghuan supports the restoration of the century-old power plant, integrating historical cultural heritage with urban renewal [2]. Group 3: Philanthropic Activities - Xinghuan has established a collaboration platform for tenants, launching the "Friendly Coffee Charity Action" in partnership with the Aide Foundation and local care centers, aiming to support families with disabled children [2]. - The "Book Donation for Hope" initiative successfully collected over a thousand children's books to aid the healthy growth of rural youth, exemplifying the concept of "business for good" [2].

安踏体育 20260626 摘要 安踏体育 2025 年下半年利润率预计同比改善，主要受益于 2024 年下 半年较低的利润率基数。FILA 品牌 2025 年全年指引为中单位数增长， 且有信心达成目标。FILA KIDS 和 FILA Fusion 子品牌增长速度快于 FILA 主品牌。 2024 年安踏体育鞋类产品营收占比约为 44%，显著高于 2021 年约 20%的占比，得益于 FILA 鞋类产品的战略部署，包括潮流鞋款和功能 性鞋类的推出。FILA 品牌计划加大力度对现有门店进行装修升级，并已 开设 ICONA 店和 FILA Box 店等新形象门店。 安踏冠军店店效达到 50 多万至近 60 万元，是安踏所有门店平均店效的 两倍以上。SNEAKERVERSE 概念店店效超过 150 万元，表现可观。超 级安踏门店数量已增至超过 80 家，但上海门店效果相对一般，仍在调 试统一的开店模型。 安踏线上业务增速预计全年快于线下，盈利能力表现良好，尽管线上打 折活动较多导致毛利率较低，但销售及管理费用占比更低。跑步品类在 鞋类销售中占比最高，达到 40%以上，篮球品类近期面临挑战，增长表 现不佳。 Q&A ...