Asia Pacific Equity Research July 2025 Asia Deep Dive: Akeso & Innovent China Healthcare Research Yang HuangAC, PhD (852) 2800 3812 yang.huang@jpmorgan.com J.P. Morgan Securities (Asia Pacific) Limited/ J.P. Morgan Broking (Hong Kong) Limited Eric Zhao, CFA (86-21) 6106 6256 eric.zhao@jpmorgan.com SAC Registration Number: S1730524050001 J.P. Morgan Securities (China) Company Limited Derek Choi, CPA (852) 2800-8744 derek.c.choi@jpmorgan.com J.P. Morgan Securities (Asia Pacific) Limited/ J.P. Morgan Broking ( ...

Rising US-Colombia tensions suggest Donald Trump’s administration is upping the pressure on Gustavo Petro ahead of a decision on the Andean nation’s status in the fight against illegal drugs https://t.co/XKELVLKgN6 ...

Group 1: Market Overview - The obesity drug market is projected to be worth $200 billion by 2031, presenting a significant growth opportunity for healthcare companies [1] - Eli Lilly and Novo Nordisk are currently the leaders in the GLP-1 weight loss drug space, generating billions in revenue from their approved products [11] Group 2: Clinical Trials and Drug Development - Amgen's MariTide, a monthly injection GLP-1 drug, has shown potential for weight loss of around 20% after one year in Phase 2 trials [6] - Recent Phase 2 trial results raised concerns due to a 27% discontinuation rate at the highest dosage because of gastrointestinal issues, although a slower dosage increase reduced this rate to less than 8% [6][7] Group 3: Competitive Landscape - The success of GLP-1 treatments hinges on patient tolerance; companies with better-tolerated treatments are likely to emerge as winners in the market [10] - If MariTide does not address side effect concerns, demand may be weak compared to established products from Eli Lilly and Novo Nordisk [11] Group 4: Investment Outlook - Amgen's stock was previously seen as an underrated growth opportunity, but recent data has led to a more cautious investment stance [12] - For investors seeking GLP-1 opportunities, Eli Lilly and Novo Nordisk are currently more favorable due to their proven products and potential for share price increases [13]

Core Insights - Processa Pharmaceuticals is focusing on oncology assets with strong differentiation and commercial opportunity to enhance shareholder value [4][9] - The company is actively enrolling patients in a Phase 2 clinical trial for its lead oncology asset, PCS6422, targeting metastatic breast cancer, with initial data expected in the second half of 2025 [2][7] - Processa has signed a binding term sheet with Intact Therapeutics for PCS12852, which could yield up to $454 million in milestone payments and a 12% royalty on future sales [7] Company Updates - The company is streamlining its development pipeline and optimizing capital allocation to focus on programs with the highest potential for clinical success [2][4] - A new adaptive pivotal Phase III study for PCS499 is being designed, following preliminary positive results in kidney disease [7] - Processa has terminated the license agreement for PCS3117 due to high costs and time requirements, returning rights to the original licensor [7] Financial and Strategic Developments - Processa has strengthened its balance sheet with a $7 million capital infusion [6] - The company is establishing a dedicated subsidiary for PCS499 to enhance strategic flexibility in capital raising and partnership exploration [7] - An investor webinar is scheduled for July 9, 2025, to discuss the company's strategic pipeline realignment and milestones [5]

中基协会6月27日发布的最新公募基金市场数据显示，4月股基、债基、货基齐增，5月继续增长，公募 基金总规模再创新高达33.74万亿元。实际上，上半年公募基金市场整体规模稳居32万亿元上方，其中 权益类基金规模稳中有进。 一直以来，主动权益基金投资能力更是被行业视为基金公司的核心竞争力。随着2025年上半年正式收 官，公募基金净值表现的"中考"成绩成为了市场关注焦点。 半程冠军涨超85% 主动权益类基金（包括普通股票型基金、偏股混合型基金、平衡混合型基金、灵活配置型基金）的表现 突出。整体来看，6471只产品上半年实现浮盈（份额分开计算），占比81.6%。 其中，中信建投基金冷文鹏管理的中信建投北交所精选两年定开A/C以82.45%/82.1%的收益领跑上半 年，且该基金也在2025年6月30日创下历史净值新高。长城医药产业精选A/C、华夏北交所创新中小企 业精选两年定开、中银港股通医药A上半年收益均超70%，另有47只产品上半年收益超50%。 据悉，2025年一季度末，公募机构在北交所的重仓配置金额达到67.43亿元，较2024年末增长24.45%， 创历史新高。同时，配置北交所股票的公募机构数量也持续上升， ...

RT BBC Politics (@BBCPolitics)"We are beginning to roll out obesity drugs on the NHS"Health Secretary Wes Streeting says there is "potential" for most obese adults in the UK to end up using weight-loss drugs#BBCLauraK https://t.co/v2HwddQuYE https://t.co/YEbiPtZHfm ...

Core Viewpoint - The performance of active equity funds has shown a positive trend in the first half of the year, with over 70% achieving positive returns, particularly in the pharmaceutical and North Exchange sectors [1][2]. Group 1: Fund Performance - As of June 26, 2023, 6085 out of 7881 equity and mixed-asset funds reported positive returns, representing over 70% [2]. - The leading pharmaceutical fund, Huazhong Pharmaceutical Bio A, achieved a return of 75.91%, while several others exceeded 50% [2]. - North Exchange-themed funds also performed well, with the CITIC Construction North Exchange Select Fund yielding 80.71% [2]. Group 2: Market Outlook - Institutions maintain a cautiously optimistic view for the second half of the year, expecting a continuation of structural market characteristics [1][3]. - Key sectors for investment include technology, new consumption, and innovative pharmaceuticals, which are seen as having strong growth potential [1][4]. - The A-share market is anticipated to exhibit clear structural features, with the index likely oscillating around a central point [3]. Group 3: Investment Strategies - Investors are advised to focus on low-entry opportunities rather than chasing high prices, given the rapid rotation of market styles [4][5]. - Specific areas of interest include technology, new consumption, stable dividend stocks, and sectors benefiting from policy support [5]. - The expected policy measures are likely to positively influence investor sentiment and the equity market [5].

The stock's market-beating momentum has come crashing to a halt, following shocking allegations from one of the world's largest pharmaceutical companies.Up-and-coming telehealth company Hims & Hers Health (HIMS 11.76%) has capitalized on the weight loss drug craze to become one of the market's top performers over the past few years.However, recently, pharmaceutical giant Novo Nordisk, the maker of popular GLP-1 agonist weight loss drug Wegovy, terminated its sales partnership with the company due to its con ...

Core Insights - The competition in the weight loss drug market is intensifying, with companies presenting new data on treatments at the American Diabetes Association conference, indicating a potential market value exceeding $150 billion annually by the end of the decade [2][3]. Eli Lilly - Eli Lilly's experimental pill, orforglipron, demonstrated a 7.6% weight loss in Type 2 diabetes patients over 40 weeks without serious side effects, with plans to launch the pill next year [3][4]. - The company is also developing bimagrumab, which aims to preserve lean muscle mass while enhancing fat loss in patients using existing treatments like Wegovy [4][5]. - Another experimental drug, eloralintide, showed promise in weight loss with minimal side effects, mimicking the hormone amylin to promote satiety [6]. Novo Nordisk - Novo Nordisk is working to catch up with Eli Lilly, having released full results from late-stage trials of its weekly injection, CagriSema, which showed significant weight loss despite initial concerns about efficacy [7][10]. - CagriSema combines cagrilintide and semaglutide, maintaining a safety profile similar to Wegovy while delivering more weight loss [10][11]. - The company is also advancing amycretin, which helped patients lose up to 24.3% of their weight after 36 weeks, with plans for both injectable and oral versions [11]. Amgen - Amgen is strategizing to enter the weight loss market with its experimental drug MariTide, which has shown significant weight loss but also high side effect rates in trials [12][13]. - The company is implementing a lower starting dose and gradual dose escalation strategy to improve patient tolerance and reduce side effects [14][15]. - Analysts believe that Amgen's approach may yield better-than-expected phase three trial results, potentially enhancing efficacy if patients remain on the drug [18].

Thiogenesis Receives Confirmatory Guidance on IMPD for Pediatric MASH Phase 2a Clinical Trial in Europe and Core Patent Granted in EUJune 25, 2025 9:00 AM EDT | Source: Thiogenesis Therapeutics, Corp.San Diego, California--(Newsfile Corp. - June 25, 2025) - Thiogenesis Therapeutics, Inc. (TSXV: TTI) (OTCQX: TTIPF), a clinical-stage biopharmaceutical company developing next-generation thiol-based therapies for mitochondrial disease and pediatric metabolic conditions, today announced that the Co ...