he’s finally offitLiz Churchill (@liz_churchill10):THIS IS WINNING 🏆Vaccine Terrorist, Dr. Paul Offit, HAS BEEN TERMINATED from the FDA.HIS MURDEROUS RAMPAGE IS OVER. https://t.co/UyoGTN5jG9 ...

Public Health Concerns - The discussion highlights concerns about a public figure (RFK Jr) potentially undermining public health efforts and spreading misinformation regarding vaccines [5][9][10] - There's worry that declining trust in agencies like the CDC, exacerbated by past mistakes and political exploitation, could lead to further damage during public health emergencies [6][7][8][9] - The importance of clear and transparent communication from public health agencies is emphasized, especially during crises, to maintain public trust and ensure adherence to recommendations [8][9] CDC Leadership and Policy - Questions are raised about potential interference in the CDC's operations, including the firing of leadership and pressure to approve immunization recommendations without proper expertise [3][4] - The discussion points to concerns about a potential anti-vaccine agenda influencing public health policy decisions [5] Vaccination and Public Trust - The proven value of vaccinations in pediatric care is underscored, emphasizing the challenges posed by misinformation in hindering public health efforts [10] - Rebuilding trust in public health agencies is recognized as a difficult task, especially when political leaders actively sow mistrust [7][8][9]

Travel & Weather Disruptions - Labor Day weekend saw millions facing extreme weather, causing travel disruptions and fatalities [1][4] - Thunderstorms in the South and Midwest may affect flights in Miami, Dallas, and Kansas City, while Newark faced delays due to staffing issues [5][6] - TSA screened 174 million passengers returning from Labor Day weekend [7] - Dangerous rip currents led to nearly 600 rescues over the weekend in LA County [7] - Heat wave impacted 25 million people across the West, with temperatures 10 to 20 degrees Fahrenheit above average [8] International Crisis - A 60 magnitude earthquake in Afghanistan resulted in at least 800 deaths, with the toll expected to rise [11][13] - The Taliban Health Ministry requested international assistance due to widespread disruption and fragile homes [13] Political & Social Issues - Protests occurred in Chicago against potential deployment of National Guard troops for immigration crackdown [2][14] - Murders are down 32% in Chicago this year, but a Democratic alderman believes federal help is needed [16] - Nine former CDC directors criticized the Health Secretary for endangering public health and downplaying measles vaccines [2][19][21] Human Interest & Rescue - A father rescued a child from a monorail track at Hershey Park [2][27][30] - An Army football player rescued a driver from a burning car [3][42] - Miami Dade Fire Rescue and the Coast Guard rescued four people from a capsized boat 7 miles offshore [43][44] Social Issue: Homelessness - Over 42000 Americans over 65 were homeless last year, and researchers estimate there could be more than 100000 by 2030 [34] - The average social security check has not kept pace with inflation, contributing to senior homelessness [34] Sports - Bill Bellichic is making his college coaching debut at the University of North Carolina, generating significant hype [3][39][40] - UNCC single game and season tickets are sold out [40]

Joining us now is Dr.. Paul Offett, the director of the vaccine education at the Children's Hospital of Philadelphia. Doctor, we just heard the former immunization chief at the CDC say, quote, he only sees harm coming. And I'm wondering, do you think that's hyperbolic? Do you think that's an exaggeration? Or do you agree with that assessment? >> I agree completely. I mean, look what's happened just over the past year. We've had the biggest measles epidemic we've had in 33 years. We had two children die of m ...

Leadership Changes at CDC - The President fired CDC Director Susan Manz less than a month into the job due to misalignment with the administration's agenda [1][2] - Four top CDC officials resigned, citing concerns about the weaponization of public health and misinformation about vaccines [4] - Former acting CDC director Richard Besser stated Manz was asked to fire her leadership team and endorse vaccine recommendations that contradicted science [2] Political Interference and Public Health Concerns - The White House defended the firing, stating officials should align with the President's agenda [3] - Concerns were raised about political interference and the spread of misinformation, potentially endangering public health [4][8][11] - A former CDC official stated America's public health is significantly in danger due to scientific integrity and political interference issues [11][12] Vaccine Policy and Access - Health Secretary Kennedy limited COVID vaccine approval to people 65 and older and those with underlying health conditions [8] - There are concerns about vaccine access due to potential insurance co-pays, with vaccine doses costing up to $140 [16] - Confusion exists regarding who should receive the COVID vaccine, potentially leading to fewer people getting vaccinated [14][17] Congressional Oversight and Reactions - Republican Senator Bill Cassidy called for oversight and urged the CDC to postpone a key vaccine meeting [4] - Senator Bernie Sanders called for an immediate bipartisan investigation into the situation [26] - There are questions about the effectiveness of congressional oversight and potential actions to address the issues at the CDC [51][52] Impact on CDC and Public Trust - The leadership changes and resignations are expected to disrupt the CDC's basic work [9] - Concerns exist about the impact on trust in information coming from the CDC [14] - A former CDC director described the situation as an all-out assault on public health, with potential dire impacts on people's lives [37][38]

And joining us now is one of those top CDC officials who is resigning today, Dr. . Dr. . Deborah Alri, the CDC's chief medical officer.Doctor, you, as we understand it, were escorted out of the CDC headquarters today. What happened and what was the final straw here. >> Yeah, so you know, over the past few months, things at CDC have been really difficult when it comes to having science and data driven decisions.And we knew there was an upcoming vaccine meeting in a few weeks and we're very concerned that the ...

Policy & Regulation - US President Trump and RFK Jr are reportedly planning to ban COVID-19 vaccine in the US [1]

Company Strategy - Bavarian Nordic's CEO believes the buyout offer highlights the capital requirements for its global vaccine powerhouse ambitions [1] Financial Implication - The proposed buyout indicates the significant investment needed to support Bavarian Nordic's growth strategy [1]

Summary of Candel Therapeutics (CADL) FY Conference Call - August 13, 2025 Company Overview - **Company**: Candel Therapeutics (CADL) - **Industry**: Biotechnology, specifically focused on cancer immunotherapy Key Points and Arguments Vaccine Approach - Candel's approach involves a novel vaccine strategy that immunizes patients against their own tumors without needing to identify specific antigens [3][4] - Utilizes a replication-defective adenovirus to deliver the HSV thymidine kinase gene, leading to localized enzyme expression and subsequent tumor cell death [4][5] - The process induces a strong pro-inflammatory response, creating optimal conditions for T cell activation against tumors [5][6] Pipeline Focus - Current focus on three main indications: - Early localized nonmetastatic prostate cancer - Borderline resectable pancreatic cancer - Therapy-resistant non-small cell lung cancer (NSCLC) [7][8] Prostate Cancer Data - Positive Phase 3 trial results with a primary endpoint of disease-free survival, showing a 30% improvement in disease-free survival rates [10][12] - Secondary endpoint showed a 38% improvement in prostate cancer-specific disease-free survival [13] - Plans to submit a Biologics License Application (BLA) by 2026 [9][10] Commercial Launch Preparation - Scaling up commercial manufacturing with partner SAFC in California [16][17] - Positive feedback from urologists and radiation oncologists regarding the adoption of CAN 2409 in combination with standard care [18][20] - Initial payer feedback has been favorable, indicating potential cost savings for healthcare systems [21] Non-Small Cell Lung Cancer (NSCLC) Data - Focus on patients with unresectable stage 3 or stage 4 NSCLC who have failed standard treatments [23] - Median overall survival of over 24 months in treated patients, doubling the expected survival [24] - Fast track designation received from the FDA based on these results [26][27] Pancreatic Cancer Data - Conducted a small randomized trial showing a median overall survival of over 32 months compared to 12.5 months in the control group [34] - Fast track and orphan drug designations received from the FDA and EMA [35] Manufacturing and Capacity - Manufacturing process involves replication-defective adenoviruses, similar to COVID-19 vaccines, with established industry capacity [38][39] - Product stability confirmed for over ten years under refrigeration [40] Future Directions - Candel is preparing for a potential registrational Phase 3 trial in therapy-resistant NSCLC and pancreatic cancer [27][35] - Ongoing exploration of CAN 3110, a next-generation oncolytic virus for glioblastoma, showing promising early results [42][45] Financial Position - Current cash runway extends into Q1 2027, with upcoming data announcements expected [53] Additional Important Information - Candel emphasizes the importance of a strong scientific rationale and unmet clinical needs in prioritizing its pipeline [36] - The company aims to advance multiple programs in parallel to maximize commercial value [37]

Vinay Prasad, who was ousted as the top vaccine and gene therapy regulator at the US Food and Drug Administration, is returning to his role https://t.co/snfLbLJi9Y ...