Seralutinib Partnership with Chiesi - Chiesi will provide a $160 million immediate development reimbursement to Gossamer[13] - Gossamer and Chiesi will split US profits 50/50, with mid-to-high teens royalties to Gossamer ex-US[13] - Regulatory milestones could reach up to $146 million, and sales milestones up to $180 million[13] - R&D costs will be split 50/50 worldwide, with Gossamer leading global development and US commercialization of PAH & PH-ILD[13] - Gossamer has a pro forma cash position of approximately $396 million[20, 38] Seralutinib in PAH - Seralutinib is in an ongoing registrational Phase 3 trial for PAH, with topline results expected in Q4 2025[13, 24, 26] - The PROSERA Phase 3 study is a double-blind, placebo-controlled trial with 175 patients per arm[26] - The US has approximately 30,000 to 50,000 PAH patients, with a 5-year survival rate of 57%[13, 22, 23, 35] Seralutinib in PH-ILD - The US has approximately 60,000 to 100,000 PH-ILD patients[13, 29, 35] - The median 5-year survival for PH-ILD patients is 23%[13, 35] - A Phase 3 study in PH-ILD is expected to begin in mid-2025[13, 20] - Only one therapy is approved for PH-ILD in the US[29, 30, 35]

Video captured the dramatic moment a Russian #drone exploded in a #Kyiv residential area as #Russia pummelled the capital with drones in an all-night attack. For more context and news coverage of the most important stories of our day, click here: https://www.nbcnews.com » Subscribe to NBC News: http://nbcnews.to/SubscribeToNBC » Watch more NBC video: http://bit.ly/MoreNBCNews NBC News Digital is a collection of innovative and powerful news brands that deliver compelling, diverse and engaging news stories. N ...

Medicus Pharma Ltd. (NASDAQ: MDCX ) describes itself as 'a biotech/life sciences company focused on accelerating the clinical development programs of novel and disruptive therapeutic assets'. The company came about in October 2023 as the result of aI have been investing in the stock market since I was 17 years old, and over the 25+ years since I have learned the joy of compounding, the value of dividend reinvesting, and the principle that patient investing through good times and bad brings the greatest rewa ...

Financial Performance & Guidance - Henry Schein reported FY2022 global net sales of $12.6 billion[8] - In Q1, GAAP diluted EPS was $0.91, and non-GAAP diluted EPS was $1.21[14] - Total sales growth was -3.8% (LCI -3.7%), but excluding PPE & COVID-19 Test Kits, LCI sales growth was strong at 6.3%[18] - EPS was negatively impacted by an estimated $0.24 due to lower contribution from PPE products and COVID-19 Test Kits, $0.04 from acquisition-related expenses, and $0.02 from foreign exchange[18] Henry Schein One & Dental Technology Market - Henry Schein One's 2022 revenue from dental practice management was approximately $550 million[20, 21] - The estimated dental technology market size is $2.3 billion, with an estimated market growth rate of 8-12%[26] - Henry Schein One has 100,000 active dental customers[26] Strategic Priorities & Market Trends - Henry Schein's strategic priorities include building complementary software, specialty, and services, operationalizing One Distribution, leveraging One Schein, and driving digital transformation[9] - Industry trends driving demand for Henry Schein One solutions include payment & claims innovation (72% of dentists are concerned with declining insurance reimbursement rates), AI & clinical decision support, customer dynamics (consumerization of healthcare), and dental practice consolidation[29, 30]

'I don't know who to trust anymore': Druze worry about being left behind in post-war Syria https://t.co/TE6VlfbRdj ...

Core Viewpoint - Toyota Motor Company is facing significant challenges due to escalating trade tensions and tariffs imposed by the US, which threaten its profit margins and overall financial performance [2][3][7]. Group 1: Company Overview - Toyota Motor Company is a leading global automaker, founded in 1973, with a diverse product portfolio that includes cars, minivans, and trucks [1]. - Approximately 50% of Toyota's revenue comes from internal combustion vehicles, while hybrid cars account for nearly 48% of sales [1]. - The company has a strong international presence, particularly in Japan, North America, Europe, and Asia [1]. Group 2: Trade and Tariff Impact - The US has imposed a 10% tariff on Japanese goods during a 90-day pause, with potential for further increases if trade agreements are not reached [2]. - President Trump's dissatisfaction with the automotive trade imbalance between the US and Japan places Toyota in a precarious position amid the trade war [2]. - Toyota is experiencing a 20.8% year-over-year contraction in profit margins due to rising material prices and US-imposed tariffs [3]. Group 3: Stock Performance - Toyota's stock is currently underperforming, trading below the 200-day moving average and down 15% over the past year [5]. - The stock is described as "dead money" for the moment, indicating a lack of upward momentum [5]. Group 4: Future Outlook - The looming July 9 tariff deadline presents significant uncertainty for Toyota, with potential tariff-induced price hikes threatening its profit margins [4][7].

This is a story about how the world's most powerful, richest country is slowly losing its influence. .And it's evident here. We can see across Brazil, thousands of Ford cars almost disappear.Meanwhile, China's BYD is becoming increasingly common. Ford. Left a plant abandoned.BYD, they modernized the plant. They are now producing electric cars from Brazil. It's evidence of the growing connection between Brazil and China, the B and the C of the BRICS+ Coalition.This is a group that hopes to rival the US-led G ...

Core Points - Vanguard Mining Corp. is applying to list 12,690,001 common share purchase Warrants on the Canadian Securities Exchange (CSE) [1][2] - Each Warrant allows the holder to acquire one common share at an exercise price of $0.10 per share before February 6, 2028 [2] - The Warrants are expected to trade under the symbol UUU.WT and will be governed by a warrant indenture with Endeavor Trust Corporation [2][3] Company Overview - Vanguard Mining Corp. is a Canadian mineral exploration company focused on discovering and developing high-value strategic minerals [4] - The company is advancing uranium exploration projects in the United States and Paraguay, targeting assets critical to the global energy transition [4] - Vanguard is committed to responsible exploration and value creation through the acquisition and advancement of highly prospective uranium properties [4]

Group 1 - Rack-scale server shipments increased more than 2x in the first quarter of this year, indicating strong demand in the market [1] - The overall server market reached a record $95.2 billion in the first quarter, showcasing significant growth [1] Group 2 - The technology sector, particularly semiconductors, artificial intelligence, and cloud software, is a primary focus for equity research [2] - Other areas of research include MedTech, Defense Tech, and Renewable Energy, indicating a diverse investment interest [2]

Today, Donald Trump spoke by phone with Russian dictator Vladimir Putin for roughly an hour. We had a call. It was a pretty long call. We talked about a lot of things including Iran and we also talked about uh as you know the war with Ukraine and uh I'm not happy about that. I'm not happy with him on on a deal with Ukraine. Do you feel like you made any progress? No, I didn't make any progress with him today at all. A unusually self-aware comment from Donald Trump. After the call, Putin's foreign policy adv ...