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Forbes· 2025-07-14 20:42
Built in 1951, the stone-and-shingle house known affectionately as Lily Hill is both New England and Old Vineyard—and, with 130 feet of fine-sand beach and a 24-foot dock, a boater’s paradise. (Photos: Tea Lane Associates)https://t.co/vBXR6UEmDj https://t.co/KEkAI7BL1J ...
Neurocrine Biosciences Presented One-Year Data from Phase 3 CAHtalyst™ Studies Showing Improvements in Weight-Related Effects of Glucocorticoid Treatment at the 2025 Endocrine Society's Annual Meeting
Prnewswire· 2025-07-14 20:35
Core Insights - Neurocrine Biosciences presented new data from the Phase 3 CAHtalyst studies showing that CRENESSITY® (crinecerfont) leads to significant improvements in weight-related outcomes for patients with classic congenital adrenal hyperplasia (CAH) [1][2][5] Group 1: Study Overview - The Phase 3 CAHtalyst program is the largest interventional clinical trial for classic CAH, involving 285 patients (103 pediatric and 182 adult) [2][12] - The studies included a double-blind, placebo-controlled period followed by an open-label period where all patients received CRENESSITY [2][12] Group 2: Weight-Related Outcomes - Adult patients treated with CRENESSITY showed a mean BMI reduction of 0.8 kg/m² compared to a 0.4 kg/m² reduction in the placebo group at Month 12 [4][6] - 39% of adult patients on CRENESSITY achieved over a 5% weight reduction, compared to 14% in the placebo group [4][6] - Pediatric patients on CRENESSITY maintained reductions in BMI standard deviation scores (SDS) through Week 52, while those on placebo saw an increase [6][4] Group 3: Insulin Resistance Improvements - Significant reductions in insulin resistance were observed in both adult and pediatric patients treated with CRENESSITY compared to placebo [5][6] - The mean HOMA-IR score decreased more significantly in the CRENESSITY group than in the placebo group [6][7] Group 4: Safety Profile - CRENESSITY demonstrated a favorable safety profile, with common side effects being mild to moderate and not leading to discontinuation of the drug [8][20] - Common side effects in children included headache and stomach pain, while adults reported fatigue and headache [8][22] Group 5: Regulatory and Market Context - Data from the CAHtalyst studies supported the FDA approval of CRENESSITY in December 2024 [15] - CRENESSITY is positioned to evolve the standard of care for classic CAH by allowing for reduced glucocorticoid doses while maintaining or improving androgen control [2][16]
3 Retail Stocks to Watch as Back-to-School Spending Ramps Up
MarketBeat· 2025-07-14 20:14
We’re past the Fourth of July, which marks the official second half of the year. For retailers, this also means the beginning of the back-to-school shopping season. This is the second biggest retail season after the holiday season. According to estimates from the National Retail Federation, in 2024, U.S. consumers spent $38.8 billion on back-to-school supplies, an average of $874.68 per household. That number was down from the record high of $41.5 billion spent in 2023. But this year, 71% of parents expect ...
Kaltura to Announce Financial Results for Second Quarter 2025 on Thursday, August 7, 2025
Globenewswire· 2025-07-14 20:10
NEW YORK, July 14, 2025 (GLOBE NEWSWIRE) -- Kaltura (Nasdaq: KLTR), the AI Video Cloud, today announced it will release its second quarter financial results for the period ended June 30, 2025, before market open on Thursday, August 7, 2025. Management will host a conference call to review the Company’s second quarter 2025 financial results and discuss the financial outlook. Date:Thursday, August 7, 2025Time:8:00 a.m. ETUnited States/Canada Toll Free:1-877-300-8521International Toll:+1-412-317-6026 A live ...
PrairieSky Announces Second Quarter 2025 Results
GlobeNewswire News Room· 2025-07-14 20:01
CALGARY, Alberta, July 14, 2025 (GLOBE NEWSWIRE) -- PrairieSky Royalty Ltd. ("PrairieSky" or the "Company") (TSX: PSK) is pleased to announce its second quarter operating and financial results for the period ended June 30, 2025. Second Quarter Highlights: Record oil royalty production of 14,376 barrels per day, an 8% increase over Q2 2024(1). Total royalty production averaged 26,457 BOE per day, a 4% increase over Q2 2024.Revenues totaled $123.6 million for Q2 2025(1) comprised of royalty production revenu ...
Meta's new superintelligence lab is discussing major AI strategy changes: NYT
CNBC Television· 2025-07-14 19:26
So joining us now for more is our own tech check anchor dear Drabosa to break down this M&A AI acquisition talent everything else war that's developing with people who have trillions of dollars in balance sheet I mean the twists and turns can be hard to keep track of uh we had we made up on tech check the sort of Mount Rushmore of AI talent meta has been the most aggressive recently but I mean you go back to Google acquiring deep mind and getting demos Habis. That was a huge move before the paychecks were i ...
Trump, NATO Strike Ukraine Weapons Deal: What’s Next for the War? | WSJ
The Wall Street Journal· 2025-07-14 19:13
From intensifying air attacks to forging ahead on the battlefield despite President Trump's calls for peace, Russia is ramping up its offensive on Ukraine. And I'm disappointed in President Putin because I thought we would have had a deal two months ago. While Donald Trump has been determined to try to get both sides to reach peace, what we see Russia doing is doubling down on its invasion.With Ukraine running low on weapons and manpower, Russia is seizing the initiative. Here's why the next months will be ...
Trump Threatens Russia with 100% Tariffs | Bloomberg Markets 7/14/2025
Bloomberg Television· 2025-07-14 19:10
♪ >> WELCOME TO BLOOMBERG MARKETS. THIS COULD -- LOOK AT A QUICK CHECK ON THESE MARKETS TO GET YOU STARTED TODAY BECAUSE THE S&P 500 HAS BEEN COVERING AROUND FLAT TERRITORY FOR THE BULK OF THE DAY. HAVE BEEN TRYING TO BREAK INTO THE GREEN.WE ARE GETTING THERE SLOWLY. THE 10 YEAR YIELD HAS BEEN RISING THROUGHOUT THE COURSE OF THE MORNING, FLUCTUATING, BUT NOW ABOUT 0.24% BASIS POINTS HIGHER. A LITTLE BIT ELEVATED RELATIVE TO RECENT WEEKS.BITCOIN ALSO ELEVATED. WHERE LOOKING AT BITCOIN RIGHT UNDER THAT $120,0 ...
Survive the AI Knife Fight: Building Products That Win — Brian Balfour, Reforge
AI Engineer· 2025-07-14 18:59
All [Music] right, I need everybody to take a deep breath here because um I'm about to stress you out and uh but hopefully at the end I'll uh relieve that stress a little bit with some ideas and solutions for you. So, I need everybody to just think for a second, reflect on the past 45 days and think about all the possible things that have gone on in our industry and all the product launches. Let me highlight just a few for you. Uh, Notion launched a Granola, Glean, and Chat GPT competitors. Figma launched a ...