【文/王力 编辑/周远方】 5月23日，中国制药龙头恒瑞医药正式登陆香港联合交易所主板，股票代码"01276.HK"，开盘价报57港 元，较发行价44.05港元高开29.4%，总市值突破3700亿港元。此次港股上市不仅是恒瑞医药继2000年A 股上市后的又一里程碑，更标志着其"创新+国际化"双轮驱动战略迈入新阶段。 恒瑞医药此次全球发售H股总数为2.245亿股，发行价定于区间上限44.05港元，募资净额约94.58亿港 元。其中，基石投资者阵容堪称豪华，包括新加坡政府投资公司（GIC）、景顺（Invesco）、瑞银全球 资产管理集团（UBS-GAM）、高瓴资本、博裕资本等国际知名机构，总认购金额约41.31亿港元，占总 发行规模的41.77%。此外，国际配售环节亦吸引主权财富基金、长线基金等大型机构参与，显示出全 球资本对中国创新药研发实力的信心。 作为国内头部药企，恒瑞医药近年来业绩稳健增长。2024年，公司实现营业收入279.85亿元，归母净利 润63.37亿元，同比分别增长22.63%和47.28%。其中，创新药销售收入达138.92亿元，占总营收的 46.3%，较2022年的38.1%显著提升。 业绩 ...

Core Viewpoint - The recent supply shortage and price increase of the Alzheimer's drug Ganluo Sodium (Jiuqi Yi) have raised concerns among patients and the public, prompting discussions about its availability and pricing [1][2][5]. Group 1: Supply Issues - Multiple regions, including Beijing, Shanghai, Guangdong, Shandong, and Heilongjiang, are experiencing shortages of Ganluo Sodium, with patients reporting difficulties in obtaining the medication [2][3]. - The manufacturer, Green Valley (Shanghai) Pharmaceutical Technology Co., has acknowledged the supply issues and is in communication with relevant authorities to address the situation [1][5]. - Over 6,000 patients have registered their demand for the drug amid the supply crisis [5]. Group 2: Price Increases - Online prices for Ganluo Sodium have surged significantly, with reports indicating a rise from approximately 300 yuan to over 540 yuan per box within a month [2][3]. - Various online platforms, including Taobao and JD.com, show prices ranging from 425 yuan to 699 yuan per box, reflecting the impact of the supply shortage on pricing [3][5]. - The company has stated that it is aware of the rapid price increases in some self-paid purchasing channels and is working to mitigate this issue [5]. Group 3: Drug Background and Controversy - Ganluo Sodium was conditionally approved for marketing in November 2019, becoming the first new drug for Alzheimer's disease approved globally since 2003 [6][9]. - The drug has been included in the national medical insurance directory and has benefited over 500,000 patients since its launch [6]. - Despite its approval, the drug has faced criticism regarding its efficacy, with ongoing clinical trials required to confirm its long-term safety and effectiveness [6][7]. Group 4: Clinical Research and Development - Green Valley has reported positive mid-term results from post-marketing clinical studies, showing cognitive and daily living improvements in patients after one year of treatment [7]. - The international multi-center Phase III clinical trial for Ganluo Sodium was prematurely terminated in 2022 due to funding issues and the impact of the pandemic, with plans to restart when conditions allow [8][9]. - The pharmaceutical industry faces significant challenges in Alzheimer's drug development, with a high failure rate and substantial investment required, highlighting the ongoing need for effective treatments [9][10].

Core Viewpoint - Rongchang Biopharmaceutical (9995.HK) has announced a H-share placement plan to raise approximately HKD 796 million, reflecting the company's ongoing financial challenges despite a significant revenue increase in 2024 [2][4]. Financial Performance - In 2024, Rongchang Biopharmaceutical reported a revenue of approximately CNY 1.72 billion, a year-on-year increase of 58.54%, but still faced a net loss of CNY 1.468 billion [3][4]. - The company has experienced losses in six out of the seven years since its establishment, with a peak loss of CNY 1.511 billion in 2023 [4][5]. - In Q1 2025, the company achieved a revenue of CNY 526 million, representing a 59.17% year-on-year growth, but continued to incur a net loss of CNY 254 million [4][7]. Product Development and Market Position - Rongchang Biopharmaceutical focuses on innovative biopharmaceuticals, particularly in antibody drug conjugates and therapeutic antibodies [4][6]. - The company has two commercialized products: RC18 (Taitasip) and RC48 (Vidisizumab), which have contributed to its revenue growth since their market approval [6][8]. - Despite the growth in sales, the company faces challenges with slowing growth rates for its core products, indicating potential market saturation or increased competition [6][8]. Funding and Financial Strategy - The recent H-share placement is a critical move to address the company's cash flow pressures and support ongoing research and development efforts [2][8]. - The company has faced difficulties in previous fundraising attempts, including a failed private placement in 2024, highlighting ongoing financial strain [9][10]. - As of Q1 2025, the company's cash reserves decreased to CNY 722 million, while short-term borrowings reached CNY 1.131 billion, indicating significant debt pressure [8][9]. Industry Context - The biopharmaceutical industry is characterized by high research and development costs and long commercialization timelines, leading to widespread financial challenges among similar companies [8]. - Experts suggest that companies need to optimize cost structures and enhance collaboration to achieve profitability in a competitive market [8].

舒泰神（北京）生物制药股份有限公司接待投资者调研纪要 形式：线下调研 参会单位:国泰海通等 接待人：董事长周志文先生 董事会秘书、副总经理于茂荣先生 证券事务代表蔡晗先生 舒泰神调研纪要 时间：2025 年 05 月 23 日 11:30-12:30 舒泰神（北京）生物制药股份有限公司接待投资者调研纪要 生产许可证是取得了 B 证，项目进度在尽快推进，此前子公司贝捷泰的融资有 助于公司的长期经营发展。 3、请问公司 STSA-1002 注射液项目目前研发进展情况？ 回答：STSA-1002 注射液项目在急性呼吸窘迫综合征适应症的 II 期临床试 验正在推进，已处于收尾阶段，希望可以取得预期的临床进展。STSA-1002 注射 液由公司自主研发，已在国内和国际申请发明专利，有全球权益。 一、投资者互动问答 1、请问公司 STSP-0601 项目目前研发及注册进展情况？ 回答：注射用 STSP-0601（"波米泰酶α "）用于伴抑制物血友病 A 或 B 患者出血按需治疗已取得 IIb 期临床研究总结报告，2025 年 01 月已公告 的 IIb 结果已达到主要有效性终点。目前正在开展 III 期临床研究，已完成 ...

河北常山生化药业股份有限公司投资者关系活动记录表 编号：2025-2 | | □特定对象调研 □分析师会议 □媒体采访 业绩说明会 | | --- | --- | | 投资者关系活动 | | | | □新闻发布会 □路演活动 | | 类别 | □现场参观 | | | □其他 (请文字说明其他活动内容) | | 参与单位名称及 | 参加公司 年度业绩网上说明会的投资者 2024 | | 人员姓名 | | | 时间 | 2025 年 5 月 23 日（周五）下午 15:00～17:00 | | 地点 | 投资者关系互动平台（http://ir.p5w.net） | | | 董事长兼总经理高晓东 | | 上市公司接待人 | 财务总监岳晓华 | | 员姓名 | 董事会秘书刘中英 | | | 独立董事曹德英 | | | 公司于2025年5月23日（星期五）15:00—17:00在全景网举 | | | 办了2024年度业绩说明会，与广大投资者进行互动交流，详见全 | | | 景网本次业绩说明会的交流内容。主要问题及回复如下： | | | 1．请问高总，艾本那肽一直没有获批，我们公司的营销队 | | | 伍几个月前已经准 ...

本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： ? 本次签署的《技术开发合同》确立了双方的合作关系，具体实施进度和 最终成果尚存在不确定性，敬请广大投资者谨慎决策，注意投资风险。 证券代码：002198 证券简称：嘉应制药 公告编号：2025-032 广东嘉应制药股份有限公司 ? 本次技术开发合同的签署不会对公司及子公司 2025 年度财务状况及经 营业绩构成重大影响，对公司未来年度经营业绩的影响将视双方后续项目的实施 进展情况确定。 一、协议签署概况 近日，广东嘉应制药股份有限公司（以下简称"公司"）全资子公司嘉应制药 （湖南）有限公司（以下简称"子公司"或"乙方"）与湖南中医药大学（以下简称 "甲方"）签署《技术开发合同》。 根据《深圳证券交易所股票上市规则》《公司章程》等相关规定，本次合同 的签署不构成关联交易，亦不构成《上市公司重大资产重组管理办法》规定的重 大资产重组，无需提交股东会和董事会审议。 二、合同签署概况 单位名称：湖南中医药大学 法定代表人：易刚强 注册资本：198,931 万元 注册地址：长沙市岳麓区含浦科教产业园学士路 3 ...

Core Viewpoint - The approval of Angladevir tablets marks a significant breakthrough for the company in the innovative drug sector, with potential for rapid market penetration in the billion-level influenza market [2][3]. Group 1: Product Approval and Clinical Data - Angladevir tablets, developed by the company's subsidiary, have received approval from the National Medical Products Administration for the treatment of adult uncomplicated influenza [1]. - The Phase III clinical trial results indicate that Angladevir significantly outperformed the placebo group in key endpoints, including the time to relief of seven influenza symptoms [2]. - The company is also developing a granule formulation of Angladevir for children and adolescents aged 2-17, with promising Phase II trial results showing shorter symptom relief times compared to adult data [2]. Group 2: Market Potential - The influenza drug market in China exceeded 10 billion yuan in 2023 and is projected to reach 22.39 billion yuan by 2027 [3]. - Current leading antiviral drugs include Oseltamivir and Marbofloxacin, with Oseltamivir sales exceeding 8 billion yuan in 2023 [3]. - Angladevir, as a PB2-targeting RNA polymerase inhibitor, shows superior efficacy against various influenza strains compared to existing treatments, including those resistant to Oseltamivir and Marbofloxacin [3]. Group 3: Financial Forecast - The company anticipates accelerated revenue growth following the commercialization of Angladevir, projecting revenues of 2.765 billion yuan, 3.216 billion yuan, and 3.774 billion yuan for 2025-2027 [9]. - Expected net profits for the same period are 300 million yuan, 391 million yuan, and 517 million yuan, with corresponding EPS of 0.35 yuan, 0.46 yuan, and 0.61 yuan [9].

Investment Rating - The report assigns a "Buy" rating for the stock of Zhongsheng Pharmaceutical (002317) based on its strong market potential and recent product approvals [1]. Core Insights - The approval of Anglavei (Anruiwei®) marks a significant breakthrough for the company in the innovative drug sector, with expectations for rapid market penetration in the over 10 billion RMB influenza market [2][3]. - The company is advancing its innovative drug pipeline, including RAY1225, which has shown promising results in clinical trials for obesity and type 2 diabetes, and ZSP1601, targeting MASH, which is progressing well in clinical trials [4][5][8]. Financial Summary - The projected revenue for Zhongsheng Pharmaceutical is expected to grow from 27.65 billion RMB in 2025 to 37.74 billion RMB by 2027, with net profit forecasts of 3.00 billion RMB and 5.17 billion RMB respectively [11]. - The company’s gross margin is projected to improve from 56.5% in 2025 to 60.6% by 2027, indicating enhanced profitability [10][11]. - The earnings per share (EPS) is expected to increase from 0.35 RMB in 2025 to 0.61 RMB in 2027, reflecting strong growth potential [11].

集采影响逐步出清，创新管线进展顺利 ——通化东宝 2024 年报&2025 年一季报点评 核心观点 盈利预测与投资建议 ⚫ 考虑到集采影响，我们下调公司收入与毛利率预期，同时上调整体费用率预期，预 测公司 2025-2027 年每股收益分别为 0.32、0.40、0.47 元（原预测值 2025-2026 年 分别为 0.44/0.58 元），参考可比公司平均市盈率，我们给予公司 2025 年 25 倍 PE 估值，对应目标价 8.00 元，维持"买入"评级。 风险提示 ⚫ 出海进度不达预期风险；新品上市不达预期风险；行业政策变动风险；新兴疗法冲 击风险；地缘政治变化风险等。 公司主要财务信息 | | 2023A | 2024A | 2025E | 2026E | 2027E | | --- | --- | --- | --- | --- | --- | | 营业收入(百万元) | 3,075 | 2,010 | 2,708 | 3,216 | 3,546 | | 同比增长 (%) | 10.7% | -34.7% | 34.7% | 18.8% | 10.3% | | 营业利润(百万元) | 1,365 | ...

张煜介绍称，今年AI赛道呈现出几大趋势，比如大模型从科研模型向产业模型转变，基础的算法算力 向实际的应用迈进。在他看来，AI编程（AI Coding）、AI智能体（AI Agent）和AI硬件将是今年三个 爆发的应用点。 被问及AI创业公司的估值问题，张煜指出，相比起前年和去年，当前估值水平已逐渐回归到理性状 态，大多数的项目与实际估值差距不大。此外，投资向头部公司聚集，例如，过去行业约有100家公 司，其中50家可获得融资，但单笔金额较小，如今可能只有10家能获得投资，但单笔融资规模显著扩 大。（徐苑蕾） "这三个领域可以真正落地，产生商业场景和价值，同时也能真正创造效益，甚至能够盈利。我们观察 了大模型很久，但是没有投资任何一个大模型，而是投资了几个行业模型，覆盖智慧大脑、工业智能、 生命科学蛋白质生成等。"张煜说。 责任编辑：杨赐 在对话中，张煜还重点谈到了人工智能新药研发（AIDD）。他表示，目前大药厂已经认可AI才是未 来。"过去大药厂认为，实验数据和病人是其重要资产，今天他们已经觉得，算法和AI的实验数据可能 会慢慢变成药厂的最重要资产。" 新浪科技讯 5月23日午间消息，第五届BEYOND国际科 ...