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Oncotelic Therapeutics Highlights Peer‑Reviewed Publication Linking TGFB2 to Survival in Younger Pancreatic Cancer Patients
Globenewswire· 2025-07-17 15:08
Core Insights - Oncotelic Therapeutics is advancing the evaluation of OT-101, an investigational antisense oligonucleotide targeting TGFB2, as a potential treatment for pancreatic ductal adenocarcinoma (PDAC) [1][5] - New research indicates that TGFB2 expression and methylation may serve as prognostic markers for overall survival in PDAC patients, particularly in younger cohorts [1][2][3] Company Overview - Oncotelic Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing RNA-targeted and small-molecule therapeutics for cancer and rare diseases [1][6] - The company has a 45% ownership interest in Sapu Biosciences, which contributed to the recent research publication [1] Research Findings - The study published in the International Journal of Molecular Sciences highlights that high TGFB2 expression correlates with reduced overall survival in patients under 65 years old, with median overall survival of 17.9 months for high TGFB2 expression compared to 66.9 months for low expression [3] - Elevated TGFB2 methylation is associated with improved survival in younger patients, with median overall survival of 66.9 months for high methylation versus 17.9 months for low methylation [3] - Clinical data from the OT-101 P001 PDAC study suggests that targeting TGFB2 is particularly beneficial for younger patients, with a median overall survival of 12.7 months in a treated subset characterized by low IL-6 [2] Market Context - The incidence of PDAC is increasing among younger adults, with approximately 4% annual growth in the 15-34 age bracket, while the five-year survival rate for all PDAC patients is only around 12% [4] - The findings underscore the need for targeted therapies like OT-101 to address the grim outcomes faced by younger PDAC patients [4]
Garrett Motion (GTX) Reports Next Week: Wall Street Expects Earnings Growth
ZACKS· 2025-07-17 15:01
The market expects Garrett Motion (GTX) to deliver a year-over-year increase in earnings on higher revenues when it reports results for the quarter ended June 2025. This widely-known consensus outlook is important in assessing the company's earnings picture, but a powerful factor that might influence its near-term stock price is how the actual results compare to these estimates.The stock might move higher if these key numbers top expectations in the upcoming earnings report, which is expected to be released ...
First Industrial Realty Trust(FR) - 2025 Q2 - Earnings Call Presentation
2025-07-17 15:00
Financial Performance - For the three months ended June 30, 2025, lease revenue was $177468 thousand, compared to $162075 thousand for the same period in 2024[14] - Net income available to common stockholders for the three months ended June 30, 2025, was $55185 thousand, compared to $51318 thousand for the same period in 2024[14] - Funds From Operations (FFO) allocable to common stockholders and unitholders for the three months ended June 30, 2025, was $102800 thousand, compared to $89647 thousand for the same period in 2024[15] - Adjusted Funds From Operations (AFFO) for the three months ended June 30, 2025, was $84160 thousand, compared to $74139 thousand for the same period in 2024[15] Portfolio Composition - As of June 30, 2025, the total number of in-service properties was 414, with a gross leasable area of 68044707 square feet and an occupancy rate of 942%[33] - Same Store NOI Cash Basis (Less Termination Fees) increased by 87% for the three months ended June 30, 2025, compared to the same period in 2024, reaching $121947 thousand[34] Debt Analysis - The total weighted average interest rate on debt outstanding was 410% as of June 30, 2025, compared to 416% as of June 30, 2024[21] - Fixed-rate debt accounted for $2379774 thousand of the total debt outstanding as of June 30, 2025[21] Leasing Activity - For the three months ended June 30, 2025, new leases commenced totaled 411 thousand square feet with a cash basis rent growth of 405%[36] - Tenant retention by square feet was 710% for the three months ended June 30, 2025[36] Outlook - The company estimates Funds From Operations - FFO (NAREIT) to be between $288 and $296 per share/unit for 2025[68]
X @CoinMarketCap
CoinMarketCap· 2025-07-17 13:36
🚨 CMC News: ETH Shorts Liquidated as Price Surges Past $3,330🔗 https://t.co/ZjOfFUawGE https://t.co/LBdV4oZzca ...
Martin Midstream Partners(MMLP) - 2025 Q2 - Earnings Call Presentation
2025-07-17 13:00
Q2 2025 Performance - Adjusted EBITDA for Q2 2025 was $27.1 million[3], compared to $31.7 million in Q2 2024[3, 4], a decrease of 14.5% - The Transportation segment's Adjusted EBITDA decreased from $11.2 million in Q2 2024 to $8.5 million in Q2 2025[3, 4], a decrease of 24.1% - The Specialty Products segment's Adjusted EBITDA decreased from $5.7 million in Q2 2024 to $4.4 million in Q2 2025[3, 4], a decrease of 22.8% - The Sulfur Services segment's Adjusted EBITDA decreased from $10.6 million in Q2 2024 to $9.7 million in Q2 2025[3, 4], a decrease of 8.5% - The Terminalling & Storage segment's Adjusted EBITDA increased from $8.0 million in Q2 2024 to $8.4 million in Q2 2025[3, 4], an increase of 5% Full-Year 2025 Guidance - The company projects a full-year 2025 Adjusted EBITDA of $109.1 million[5] - Total segment adjusted EBITDA is projected to be $123.8 million[5] - Maintenance capital expenditures are estimated at $20.5 million, and plant turnaround costs at $5.4 million[5] - Total distributable cash flow is projected to be $27.8 million[5] - Total adjusted free cash flow is projected to be $18.8 million[5]
X @Bitcoin Magazine
Bitcoin Magazine· 2025-07-17 12:46
RT Bitcoin Magazine Pro (@BitcoinMagPro)We've recently witnessed a spike in the Bitcoin Supply Adjusted Coin Days Destroyed, which weights on-chain transactions not only by the amount of BTC being transferred but also by the amount of time it had been held. 👀Are large & long-term holders now taking profits? 👇 https://t.co/CCelLT67AY ...
Meeks: Netflix shows 45% earnings growth but price reflects much of that
CNBC Television· 2025-07-17 12:43
Financial Performance - The company's estimated earnings growth year-over-year is 45% [1] - Last quarter, the company beat analyst estimates by 17% [2] Strategic Focus & Growth Drivers - Live events are considered a key leg to the company's growth, including sporting events, unscripted shows, and celebrity interviews [6] - The company had a big price increase in late January, and continued traction is being monitored [3] - The company's ad-supported tier is a big deal, and its traction is being monitored [3] - The company stopped reporting quarterly net subscription additions two quarters ago, shifting focus to other metrics [4] Competitive Landscape - The company has a content lead, enabling subscriber acquisition and further content investment, creating a virtuous cycle domestically and internationally [8] - AI is considered a greater threat to digital advertisers like Meta or Alphabet than to the company [11] Key Metrics - Viewership of the July 11th Taylor Serrano fight is a key metric for the current quarter [3][4] - The July 11th fight was part of a trilogy and an all-women's boxing card [4]
INNOVATE Launches Indebtedness Refinancing Transactions
Globenewswire· 2025-07-17 12:42
Core Viewpoint - INNOVATE Corp. is initiating a series of refinancing transactions aimed at extending the maturities of its debt obligations, which includes exchanges of convertible and senior secured notes, as well as amendments to existing credit agreements [1][2][3]. Debt Refinancing Transactions - The company plans to exchange approximately $48.7 million of its existing 7.5% Convertible Senior Notes due 2026 for about $51.1 million of newly issued 9.5% Convertible Senior Notes due 2027 [2]. - An exchange offer has been launched for $330 million of 8.5% Senior Secured Notes due 2026, offering new 10.5% Senior Secured Notes due 2027 [3][4]. - The refinancing transactions are contingent upon the participation of at least 98% of the outstanding principal amount of the Existing Senior Secured Notes [7]. Agreements in Principle - The company has reached agreements in principle to extend the maturity of its 2020 Revolving Credit Agreement to September 15, 2026 [13]. - An agreement has been made to extend the maturity of the CGIC note to April 2027, with an interest rate of 16% [14]. - The maturity of Spectrum Notes is set to be extended to September 30, 2026, contingent on meeting certain strategic milestones [15]. - The maturity of R2 Technologies' note is proposed to be extended to August 1, 2026, with an interest rate of 12% [16]. Participation and Deadlines - The early participation deadline for the exchange offer is set for July 30, 2025, with the final settlement expected on August 15, 2025 [8]. - Supporting Noteholders, representing approximately 75.3% of the Existing Senior Secured Notes, have agreed to participate in the exchange offer [6].
Magna Terra Discovers Copper Mineralization and Completes Airborne Geophysical Survey at the Humber Copper-Cobalt Project in Newfoundland
Newsfile· 2025-07-17 12:00
Magna Terra Discovers Copper Mineralization and Completes Airborne Geophysical Survey at the Humber Copper-Cobalt Project in Newfoundland July 17, 2025 8:00 AM EDT | Source: Magna Terra Minerals Inc. Toronto, Ontario--(Newsfile Corp. - July 17, 2025) - Magna Terra Minerals Inc. (TSXV: MTT) ("Magna Terra" or the "Company") is pleased to announce that it has discovered copper mineralization during early- stage prospecting at its 40,675-hectare, 100% owned Humber Copper-Cobalt Project (the "Humber Project" or ...
Abbott Reports Second-Quarter 2025 Results
Prnewswire· 2025-07-17 11:30
Second-quarter reported sales growth of 7.4 percent; organic sales growth of 6.9 percent or 7.5 percent excluding COVID-19 testing-related sales1 Second-quarter GAAP diluted EPS of $1.01; adjusted diluted EPS of $1.26 Reported gross margin of 52.7 percent of sales; adjusted gross margin of 57.0 percent, which reflects a 100 basis point increase Reported operating margin of 18.4 percent of sales; adjusted operating margin of 22.9 percent, which reflects a 100 basis point increaseABBOTT PARK, Ill., July 17, ...