Core Insights - Cue Biopharma, Inc. has received positive Pre-IND feedback from the FDA regarding its lead autoimmune asset, CUE-401, a first-in-class bispecific molecule designed to induce and expand regulatory T cells (Tregs) in vivo [1][2] - CUE-401 utilizes the combined activities of transforming growth factor beta (TGF-β) and a modified variant of interleukin 2 (IL-2) to potentially provide durable immune rebalance and tolerance for various autoimmune diseases [2][4] Company Overview - Cue Biopharma is a clinical-stage biopharmaceutical company focused on developing a novel class of therapeutic biologics that selectively engage and modulate disease-specific T cells for autoimmune disease treatment [1][8] - The company’s proprietary platform, Immuno-STAT™, aims to harness the body's intrinsic immune system without the adverse effects of broad systemic immune modulation [8] Product Details - CUE-401 is engineered to enhance the Treg induction capacity of TGF-β combined with IL-2 signaling, which is believed to improve the quality and stability of Tregs [5][6] - The design of CUE-401 allows for "conditional binding," which minimizes off-target activity and simplifies manufacturing processes [6] Mechanism of Action - CUE-401 acts as a master switch to convert autoreactive effector T cells into stable, induced T-regulatory cells (iTregs), establishing a 'tolerance positive feedback loop' that increases nonspecific Treg populations while reducing autoreactive T cells [7]

[Applause] [Music] [Applause] Hi everyone. I'm so excited to be here um and talk to you about something that's really close to my heart, gender narratives. I'm going to start with introducing you to my niece Eva and nephew Ari.About three years ago, when they were seven and four, I overheard a conversation between Eva and Ari where Eva told Ari, "Arri, you're so lucky to be a boy because when you grow up, you can be anything. But I'm not excited to grow up because I have to be a wife and I have to have a ba ...

U ovom iskrenom i nadahnjujućem govoru, Sonja Vasić, nas vodi kroz svoje životne faze - od detinjstva ispunjenog snovima, preko izazova i trijumfa u profesionalnoj košarkaškoj karijeri, do uloge majke, supruge i sportske liderke. Kroz lična iskustva, povrede, sumnje i velike preokrete, Sonja govori o važnosti balansa, autentičnosti i vrijednosti koje nas vode kroz odluke. Njena poruka je snažna - da ne moramo birati između porodice i karijere, snage i ranjivosti, ambicije i mira. Umesto toga, možemo i moram ...

方正证券发布研报称，刚果(金)作为全球钴供应主产国（2024年产量占比75.9%），其暂停钴出口4个月 的政策将显著打破市场供给过剩预期，政策出台后钴价已上涨14.5%至18.2万元/吨。基于对钴金属价格 的乐观预期，该行建议关注华友钴业（603799）、腾远钴业（301219）、寒锐钴业（300618）、洛阳钼 业（603993）等。 钴价处于历史底部位置，刚果(金)政府稳价意愿强烈 2月24日中国钴金属价格为15.9万元/吨，为2007年以来的底部位置。在刚果(金)禁止出口政策出台后， 截至2月27日，钴金属价格上涨14.5%至18.2万元/吨。考虑到刚果(金)政府声明将在3个月后对政策效果 进行评估，该行认为刚果(金)政府稳价、挺价意愿强烈。 出口禁令有望重塑钴金属过剩格局 该行认为2022年以来钴金属价格的持续下跌，一方面是三元正极材料的市占率下滑，特别是低镍高钴产 品的占有率下降导致需求增速不及预期。另一方面是由于铜价高企，刚果(金)铜产量快速提升，导致伴 生钴产量大幅增长。该行认为随着三元占比下滑趋势的减弱以及消费电子国补下需求复苏，将会使钴金 属需求恢复平稳增长。而出口禁令将显著减少钴金属流入量 ...

June 17, 2025 04:01 AM GMT North American Energy | North America Navigating Geopolitical Risks & Stronger Oil WTI has rallied ~20% in June alongside rising geopolitical risks. Near-term strength could continue, but prices are biased lower in 2H25 absent supply disruption. Post recent moves, we revisit views across the Energy Sector. From here, we remain selective with a defensive bias & prefer gas over oil. Key Takeaways The Extel Survey is now open. We would greatly appreciate your support for the Joy.Golu ...

[Applause] [Music] [Applause] true or false no one wants to work anymore this is a common refrain I've heard from business owners over the past 5 to 10 years especially over the last five you may have even said it yourself owners and managers are always looking for help especially in today's market and many struggle to find and retain good help and it is true employees have the absolute pick of the litter when it comes to their chosen jobs and careers so they won't apply for let alone stay at a job that doe ...

Proceeds will be used to repay debtRogers will maintain full operational control of its wireless network TORONTO, June 20, 2025 (GLOBE NEWSWIRE) -- Rogers Communications Inc. (TSX: RCI.A and RCI.B; NYSE: RCI) today announced it has closed its CDN$7 billion equity investment from funds managed by Blackstone, backed by leading Canadian institutional investors. Blackstone has acquired a non-controlling interest in a new Canadian subsidiary of Rogers that owns a portion of Rogers wireless backhaul transport inf ...

智通财经APP获悉，6月20日，香港政府统计处发布2025年第一季香港国际收支平衡及国际投资头寸的 初步统计数字，并一并发布同期的香港对外债务的初步统计数字。香港于2025年第一季录得854亿港元 的国际收支赤字（相当于本地生产总值的10.7%），而储备资产相应地减少同等数额。2024年第四季则 录得314亿港元的盈余（相当于本地生产总值的3.8%）。 经常账户 2025年第一季的经常账户录得1252亿港元盈余（相当于本地生产总值的15.7%），这反映香港储蓄多于 投资，令其累积对外金融资产（例如股本证券或债务证券），在环球金融波动时提供缓冲。与2024年第 一季的953亿港元经常账户盈余（相当于本地生产总值的12.4%）比较，盈余增加主要是由于初次收入 净流入和服务贸易盈余增加所致。 在2025年第一季季末，香港的对外金融资产和负债总值均处于很高的水平，分别为544851亿港元（相当 于本地生产总值的17.0倍）和375622亿港元（相当于本地生产总值的11.7倍），这是一个重要国际金融 中心常见的特点。 在2025年第一季季末，香港的对外金融资产净值（即资产扣除负债）达169229亿港元（相当于本地生产 ...

Asia Value & Moat Stocks is a research service for value investors seeking Asia-listed stocks with a huge gap between price and intrinsic value, leaning towards deep value balance sheet bargains (i.e. buying assets at a discount e.g. net cash stocks, net-nets, low P/B stocks, sum-of-the-parts discounts) and wide moat stocks (i.e. buying earnings power at a discount in great companies like "Magic Formula" stocks, high-quality businesses, hidden champions and wide moat compounders). Sign up here to get starte ...

Asia Value & Moat Stocks is a research service for value investors seeking Asia-listed stocks with a huge gap between price and intrinsic value, leaning towards deep value balance sheet bargains (i.e. buying assets at a discount e.g. net cash stocks, net-nets, low P/B stocks, sum-of-the-parts discounts) and wide moat stocks (i.e. buying earnings power at a discount in great companies like "Magic Formula" stocks, high-quality businesses, hidden champions and wide moat compounders). Sign up here to get starte ...