Core Insights - Artelo Biosciences, Inc. presented new data at the British Pain Conference, highlighting the therapeutic potential of Fatty Acid Binding Protein (FABP) inhibitors for treating osteoarthritis (OA) pain [1][2] - The lead FABP5 inhibitor, ART26.12, demonstrated analgesic effects comparable to naproxen in animal studies, with sustained effects over 28 days [4][3] - OA affects approximately 606.9 million people globally, with over 32 million in the U.S., leading to significant mobility loss and reduced quality of life [5] Company Overview - Artelo Biosciences is a clinical-stage pharmaceutical company focused on developing therapeutics that modulate lipid-signaling pathways for various conditions, including cancer, pain, and inflammation [7] - The company is advancing a portfolio of product candidates aimed at addressing unmet medical needs across multiple diseases [7] - ART26.12 is currently undergoing human trials, with initial clinical development targeting chemotherapy-induced peripheral neuropathy (CIPN) [6]

Core Insights - The China Commodity Price Index (CBPI) for May 2025 is reported at 110.3 points, reflecting a month-on-month increase of 0.3% but a year-on-year decrease of 7.2% [1][3] - The index shows signs of stabilization and improvement due to a temporary easing of US-China trade tariffs, which has restored some market confidence [1][3] - Despite the recovery in global commodity prices, external uncertainties and insufficient effective demand remain significant challenges for various industries [1][3] Price Index Summary - The CBPI increased from 109.9 points in April to 110.3 points in May, with a month-on-month rise of 0.4 points [3] - The energy price index decreased to 96.3 points, down 2.1% month-on-month and down 14.9% year-on-year [3][4] - The chemical price index rebounded to 102.8 points, with a month-on-month increase of 0.5% but a year-on-year decline of 13.7% [3][4] - The black metal price index fell to 78.7 points, down 0.8% month-on-month and down 11.4% year-on-year [3][4] - The non-ferrous metal price index rose slightly to 127.7 points, up 0.9% month-on-month but down 5.2% year-on-year [3][4] - The agricultural product price index increased to 98.2 points, with a month-on-month rise of 0.5% and a year-on-year increase of 2% [3][4] Commodity Price Movements - Among 50 monitored commodities, 32 (64%) saw price declines while 17 (34%) experienced price increases in May [5] - The top three commodities with price increases were PTA (up 9.5%), ethylene glycol (up 4.6%), and corn (up 4.3%) [5] - The largest price declines were observed in industrial silicon (down 10.2%), lithium carbonate (down 10%), and soybean meal (down 9.9%) [5]

Core Insights - The article discusses the challenges faced by HR Business Partners (HRBPs) in creating value for business departments, highlighting that they often revert to traditional administrative tasks rather than providing strategic support [2][4][8] - It emphasizes the need for HRBPs to shift their focus from transactional work to understanding and enhancing organizational strategy and effectiveness [3][5][6] Group 1: HRBP Challenges - HRBPs are often perceived as not adding significant value, merely performing traditional tasks in a different location [2][4] - Business departments typically request HRBPs to assist with recruitment rather than strategic initiatives, indicating a lack of trust in HR's ability to drive business performance [2][3] Group 2: Strategic Value Creation - To create professional value, HRBPs should engage with business departments by addressing organizational issues that impact strategic execution [4][5] - HRBPs can facilitate discussions around organizational adjustments to improve performance, thereby aligning with business leaders' strategic goals [5][6] Group 3: Organizational Analysis - HRBPs should analyze business processes before organizational structure to identify inefficiencies and areas for improvement [6][7] - A lack of clarity in processes and roles often indicates deeper strategic misunderstandings within business departments, presenting an opportunity for HRBPs to add value [7][8] Group 4: Effective HRBP Engagement - HRBPs should avoid rushing to solve minor issues and instead focus on identifying and addressing key strategic problems [8] - By enhancing organizational effectiveness, HRBPs can better utilize existing talent and contribute to overall business success [8]

Group 1: Michael Burry's Investment Actions - Michael Burry sold off his entire investment portfolio in Q1, except for Estee Lauder, in which he doubled his position [2] - He bought put options on Nvidia and several Chinese ADRs, indicating a bearish outlook on these stocks [3] - Burry's actions suggest a strategic pivot, betting against the U.S. and Chinese markets while maintaining confidence in Estee Lauder [4] Group 2: Estee Lauder's Business Overview - Estee Lauder is a global beauty conglomerate with a portfolio of luxury brands, including Clinique, MAC, and La Mer [5] - The company has faced challenges due to its exposure to China and the duty-free shopping market, with sales in China recovering slowly post-COVID [6][7] - Increased competition from newer prestige beauty brands has also impacted Estee Lauder's market position in the U.S. [9] Group 3: Financial Performance and Strategy - Estee Lauder's sales declined by 10% and adjusted operating income fell by 27% last quarter, with retail travel revenue dropping 28% [14] - The company is implementing a profit recovery and growth plan, which includes cost reductions and layoffs to restore sales growth and improve margins [13] - Despite current challenges, if the company can regain lost earnings, there could be significant upside potential for its stock [15][16]

Group 1 - The focus has shifted towards offshore drilling, supply industry, and shipping, including tankers, containers, and dry bulk [1] - The fuel cell industry is being monitored as it is still in its early stages of development [1] Group 2 - The individual has extensive experience in auditing with PricewaterhouseCoopers before transitioning to day trading nearly 20 years ago [2] - Successfully navigated significant market events such as the dotcom bubble, the aftermath of the World Trade Center attacks, and the subprime crisis [2]

Group 1 - The focus has shifted from primarily tech stocks to include offshore drilling, supply industry, and shipping sectors such as tankers, containers, and dry bulk [1] - There is an emerging interest in the fuel cell industry, which is still in its nascent stage [1] Group 2 - The individual has extensive experience in auditing with PricewaterhouseCoopers before transitioning to day trading nearly 20 years ago [2] - The individual successfully navigated significant market events including the dotcom bubble burst, the aftermath of the World Trade Center attacks, and the subprime crisis [2]

Core Viewpoint - Companies are increasingly pushing for "business-people integration" and "business-finance integration" through the deployment of Business Partners (BPs), aiming to establish a three-pillar structure consisting of Centers of Excellence (COE), Shared Services Centers (SSC), and BPs. However, the value of BPs is not widely recognized in most companies today [1] Group 1: Understanding Business - The first challenge for HR and finance BPs is to truly understand the business, as their current understanding is often superficial and lacks depth [2][3] - There is a disconnect between business personnel and BPs, with business personnel feeling that BPs do not understand the frontline realities, while BPs believe business personnel are not being truthful about their situations [3] Group 2: Professional Support - The second challenge is providing professional support once business issues are identified. BPs must translate business models into processes, structures, and compensation plans, which requires a high level of expertise [4] - Many BPs feel constrained by corporate frameworks, limiting their ability to provide meaningful insights and solutions [5] Group 3: Relationship Management - The third challenge involves maintaining appropriate relationships with business units. Some BPs resort to informal methods, such as socializing over drinks, to integrate with business teams, which can undermine their professional credibility [6] - Genuine integration should be based on professional respect rather than personal relationships, as relying on emotional connections can lead to a misunderstanding of the BP's value [7]

Group 1 - Seed Round and Angel Round financing are critical starting points for startups, with Seed Round typically involving around one million dollars for initial operations and Angel Round ranging from hundreds of thousands to millions of dollars after a prototype is developed [2][3]. Group 2 - A comprehensive business plan (BP) is essential for securing financing, showcasing project potential and value, including market analysis, product features, team experience, and financial forecasts [3][8][9]. Group 3 - The core team is vital for startup success and attracting investment, with emphasis on past achievements and collaboration capabilities to instill investor confidence [10]. Group 4 - Angel investors provide not only capital but also strategic guidance and resources, with avenues for connecting with them including startup events and social networks [11]. Group 5 - Venture capital firms focus on the innovation, sustainability, and profitability of business models, with successful examples like ByteDance attracting significant investment due to their unique models and rapid growth [12][13]. Group 6 - Effective fund management post-financing is crucial for startup survival, requiring detailed budgeting and strategic allocation of resources to areas like product development and marketing [16]. Group 7 - Maintaining good communication with investors is key for ongoing development, involving regular updates and feedback on company progress and challenges [17].

财务和人力部门派出BP，我们尚且可以用"三支柱设计（COE、SSC和BP三大组织部件）"的传统来解释；而其他职能部门派出BP，就需要找到新的原 因。事实上，就算是HRBP和FBP两个角色，大量先锋企业似乎也有了新的定义——要求他们对于业务决策起到更强的支持作用。 那么，这种变革背后的原因是什么？方向是什么？推进到哪个阶段了？未来的难点是什么？ 本项研究选取了BATM（字节跳动、阿里、腾讯、美团）四大一线互联网公司和京东这家准一线互联网公司，加上华为、海尔两家在组织创新上最前沿的 传统企业，以其在公开招聘网站上发布的HRBP和FBP岗位说明书为依据，结合对于从业者的若干补充调研，对上述问题进行了研究。 BP化，大势所趋 组织转型才是真正的原因。互联网时代，当一线经营单元要求极致的灵活性，要求授权、激励、赋能下沉，必然挑战企业的人、财、法这类职能管理机构 的顶层政策，BP自然成了一个平衡"经营"和"管理"之间矛盾的均衡器。 具体来看，组织转型走向"BP化"可能有三大原因： 一是解决授权问题，在"一管就死"和"一放就乱"之间平衡。市场变幻莫测，企业希望让一线听得见炮火的人来呼唤炮火，但又不敢给予一线无限授权。 当前 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 糖尿病 是一种重大且持续存在的全球健康挑战。流行病学研究表明， 焦虑障碍 属于最常见的精神疾病之 一，对一亿糖尿病患者构成严重威胁。在遗传上易患糖尿病的啮齿动物中，也观察到了焦虑样行为增多。 在糖尿病相关因素中，中枢胰岛素抵抗与认知缺陷有关，并曾被认为是焦虑障碍的一种潜在诱因。然而， 通过特异性敲除小鼠脑部的胰岛素受体，并未导致年轻小鼠出现焦虑样行为。 胰岛素对行为的影响也受到性别差异的影响，这表明其他糖尿病因素可能参与焦虑症的形成。 高血糖 是糖 尿病的另一个特征；然而，其对焦虑症的影响仍不完全明确。 2025 年 5 月 6 日，中国科学院上海药物研究所 李佳 团队和临港实验室 臧奕 团队合作，在 Nature 子刊 Nature Metabolism 上 发表了题为： Neuronal CCL2 responds to hyperglycemia and contributes to anxiety disorders in the context of diabetes 的研究论文。 该研究发现， 高血糖 可通过调节中央前额叶皮层和腹侧海马的神经元 CCL2 及 ...