Core Viewpoint - The article discusses the development of a long-acting IL-2 release platform using pressure-fused biomineral tablets, which enhances antitumor immune response and addresses the limitations of traditional IL-2 therapies [3][4][10]. Group 1: Long-acting Drug Delivery - Long-acting formulations can maintain drug release for weeks, months, or even years, improving patient compliance and therapeutic efficacy [2]. - Biominers like calcium carbonate (CaC) and calcium phosphate (CaP) are promising materials for constructing long-acting formulations due to their high biocompatibility and stability [2][6]. Group 2: Research Development - The research team developed a dynamic control platform for IL-2 release through the fusion of amorphous CaC and CaP under high pressure (2 GPa) [6][7]. - A hybrid biomineral with the formula Ca(CO3)x(PO4)2(1−x)/3 was created, demonstrating crystallization-driven release behavior to optimize IL-2's in vivo fate [7]. Group 3: Experimental Results - The formulation consisted of 7.5 mg of CaC nanoparticles, 2.5 mg of CaP nanoparticles, and 30 µg of IL-2, which were completely fused under pressure to form a transparent IL-2@Ca(CO3)1/2(PO4)1/3 tablet [8]. - The Ca(CO3)1/2(PO4)1/3 tablet reshaped the immunosuppressive tumor microenvironment, enhancing the distribution of IL-2 and preferentially activating cytotoxic T cells and memory T cells, leading to weeks of IL-2 retention [9]. Group 4: Antitumor Efficacy - In a melanoma model in female mice, the Ca(CO3)1/2(PO4)1/3 tablet exhibited excellent antitumor effects, inhibiting local tumor recurrence and preventing the growth of untreated distal tumors while maintaining a long-term T cell response [10].

Group 1 - The core viewpoint of the news highlights the recent performance of Green Leaf Pharmaceutical, which saw a significant stock price increase despite a decline in financial metrics [1][2] - Green Leaf Pharmaceutical's stock price rose by 9.46% to HKD 3.82 per share, with a trading volume of 307 million shares and a turnover of HKD 1.148 billion, indicating high market activity [1] - Over the past month, Green Leaf Pharmaceutical has experienced a cumulative increase of 78.97%, and a year-to-date increase of 60.83%, outperforming the Hang Seng Index by 21.47% [1] Group 2 - Financial data for Green Leaf Pharmaceutical shows total revenue of CNY 6.061 billion for the year ending December 31, 2024, a decrease of 1.33% year-on-year, and a net profit of CNY 472 million, down 11.4% year-on-year [1] - The company's gross profit margin stands at 66.72%, with a debt-to-asset ratio of 46.8% [1] - Currently, there are no institutional investment ratings for Green Leaf Pharmaceutical, and its price-to-earnings ratio is 25.76, ranking 53rd in the pharmaceutical and biotechnology industry, which has an average P/E ratio of 4.2 [2] Group 3 - Green Leaf Pharmaceutical focuses on the development, production, promotion, and sales of innovative drugs in major therapeutic areas such as oncology, central nervous system, cardiovascular, and digestive and metabolic diseases [3] - The company has a product portfolio of over 30 products, covering more than 80 countries and regions, including major pharmaceutical markets like China, the US, Europe, and Japan [3] - Green Leaf Pharmaceutical has established a nationwide sales and distribution network in China, reaching over 19,330 hospitals, including approximately 87% of tertiary hospitals and 66% of secondary hospitals [3] - The company has a strong research and development team consisting of 824 employees, including 73 PhDs and 438 master's degree holders, and holds numerous patents in both China and overseas [3]

| 市呈现小幅牛陡走势。短期来看，资金面紧张预期走弱，债市有望偏强震荡。 | | --- | 请务必阅读正文之后的免责条款部分 EVERBRIGHT FUTURES 2 光大期货金融期货日报 光大期货金融期货日报（2025 年 06 月 12 日） 一、研究观点 | 品种 自 | 点评 6 月以来，中国资产表现偏强，股债齐升，计价 6 月可能存在的政策变化。 | 观点 | | --- | --- | --- | | 股指 | | 震荡 | | | 其一，中美沟通进度超市场预期。6 月 9 日，中美将在伦敦开展新一轮贸易 | | | | 谈判，具体内容可能超过市场预期；其二，长效消费刺激政策受到市场关注， | | | | 消费促进政策思路可能出现变化；其三，6 月中下旬陆家尊论坛可能包含深 | | | | 化资本市场改革的进一步举措。近期公布的 PPI 数据显示，我国经济通胀水 | | | | 平仍处于低位，二季度基本面可能转化为"弱现实、强预期"，市场风格中消 | | | | 费和科技可能仍然占优。财报方面，一季度，A 股上市公司全市场营收增速 | | | | 跌幅连续 3 个季度收窄，但仍低于政策利率，净利 ...

Core Viewpoint - The Ministry of Ecology and Environment emphasizes the need for strict actions against illegal dumping and disposal of solid waste, focusing on comprehensive inspections and rectifications of related issues [1] Group 1: Illegal Dumping and Waste Management - A special rectification action will be launched to address illegal dumping and disposal of solid waste, with a focus on identifying and correcting these issues [1] - The ministry aims to crack down on illegal dumping behaviors and the profit chains behind them [1] - There will be a thorough investigation into environmental pollution risks at landfill sites, particularly concerning leachate accumulation and groundwater contamination [1] Group 2: Long-term Management Strategies - The ministry plans to analyze the root causes of these issues and develop fundamental solutions to prevent future occurrences [1] - A long-term mechanism for comprehensive solid waste management will be established to ensure ongoing prevention of pollution problems [1]

Group 1 - Tianjin is promoting the "technology-industry-finance" new cycle mechanism to enhance the depth and effectiveness of technology finance through improved organizational systems, credit services, insurance guarantees, and pilot equity investments [1] - As of 2023, Tianjin has established 61 technology-focused branches within its banking institutions, with a loan balance of 288.3 billion yuan to technology innovation enterprises, marking a 20% year-on-year increase, and 50% of these loans are credit loans [1] - The Tianjin insurance industry has provided insurance coverage of 486.49 billion yuan through technology insurance, with the "laboratory all-risk insurance" covering 1.14 million yuan for 46 laboratories [1] Group 2 - A new long-term mechanism for the "technology-industry-finance" cycle has been jointly issued by Tianjin financial regulatory authorities, expanding financial service institutions to include securities, funds, leasing, and factoring [2] - The work plan includes six key measures with 15 specific initiatives aimed at enhancing financial services for technology innovation, including strengthening top-level design, improving organizational structure, and optimizing financial support products [2] - The Tianjin financial regulatory bureau aims to guide financial institutions to increase support for technology innovation, focusing on the financial needs of technology innovation and enhancing the adaptability of financial services [2]

Group 1 - The recent suspension of the "National Subsidy" program in some regions is primarily due to the exhaustion of previous subsidy funds, with new funds yet to be allocated [1][2] - As of May 31, the total consumption of the national subsidy funds reached approximately 1550 to 1650 billion yuan, accounting for half of the total scale of 3000 billion yuan [1] - The "618" shopping festival is expected to further consume subsidy funds, while companies are also engaging in discount promotions, particularly in the automotive sector, indicating a downward price trend [1][2] Group 2 - The suspension of the "National Subsidy" is aimed at avoiding fund misallocation and price interference, with expectations for adjustments and continuation in the second half of the year [2] - Retail sales of home appliances have shown significant growth, with a 38.8% year-on-year increase in April for major retail units, marking the highest growth among 16 categories of consumer goods [2] - The government has implemented four rounds of consumer subsidy policies since 2009, with previous rounds demonstrating a high multiplier effect on consumption during the subsidy period, although this effect tends to decline over time due to overdraw effects and increased product ownership [2] Group 3 - The use of fiscal subsidies to promote consumption is seen as a short-term measure, while establishing a long-term mechanism for expanding domestic demand is essential for sustainable growth [3] - The government aims to create a virtuous cycle between economic development, income increase, and consumption expansion, emphasizing the need for a balance between short-term policy incentives and long-term institutional building [3] - Recent government directives highlight the importance of investing in people and improving livelihoods, which will support the foundation for expanding consumption [3]

Group 1 - The core viewpoint emphasizes the need for continuous improvement in long-term consumption promotion mechanisms to stimulate market vitality, as evidenced by a 4.7% year-on-year growth in retail sales of consumer goods in the first four months of the year, which is a slight acceleration from the first quarter [1] - The article highlights the importance of enhancing the evaluation and incentive mechanisms for local governments to promote consumption, as funding for consumption promotion often does not yield immediate returns and can crowd out rigid expenditures [1] - It suggests that a well-structured assessment system should guide local governments to prioritize consumption promotion, increase investment in consumption infrastructure, and optimize the consumption environment [1] Group 2 - The article advocates for a prudent regulatory approach that fosters the growth of new consumption formats while ensuring necessary oversight, emphasizing the need for a supportive business environment to unleash market vitality [2] - It stresses the importance of increasing income and reducing burdens for low- and middle-income groups to enhance their consumption capacity and willingness, indicating that economic development should focus on improving residents' consumption rather than merely serving as a short-term regulatory tool [2] - The need for a balanced income distribution mechanism is highlighted, aiming to expand the middle-income population and ensure that consumption policies help consumers access products and services that meet their needs [2] Group 3 - The current transition in China's consumption patterns from physical goods to services and from survival-based to development-oriented consumption is noted, indicating a significant historical shift [3] - The article calls for a focus on improving supply quality to address product and service gaps, accelerate the cultivation of new consumption formats, and expand consumption spaces [3] - It emphasizes the importance of enriching consumer experiences and leading market demand through high-quality supply [3]

本站讯 近日，广东省水利厅印发《关于进一步做好汛期水利工程巡查工作的通知》（以下简称《通 知》），通过明确巡查主体、规范类别频次、创新方法机制、强化隐患闭环管理等举措，构建汛期水利 工程巡查长效机制，全力保障水利工程安全运行。 《通知》明确水利工程巡查实行岗位责任制，水库（水电站）、水闸、堤防等工程需由管理单位或主管 部门逐宗（逐堤段）指定巡查人员。巡查人员须为防汛巡查责任人、熟悉工程情况的技术人员，或通过 技能培训考核的专业人员，并接受上级部门监督，确保主体责任不折不扣落到实处。 对于巡查类别和频次，《通知》将汛期水利工程巡查划分为日常巡查、临灾排查、灾中检查、灾后复查 四类。日常巡查中，水库（水电站）工程每日不少于1次，堤防工程（以堤段为单元划分责任区）、水 闸工程每周不少于1次（间隔≥3天），其他类型工程按重要程度和实际需要动态调整。一旦预报有台 风、强降雨或洪水后，须按照"临灾前再查一遍"的要求，聚焦防洪薄弱环节和历史隐患点，对所有水利 工程开展隐患排查。遭遇强降雨、洪水时，则立即启动灾中检查，当江河湖泊水位达到警戒水位、发生 洪水漫滩，或工程出现设备故障、水位骤变、少量渗水等异常时，须增派力量、加密 ...

强化监督执纪。充分发挥纪检监察机关监督基本职责、第一职责作用，聚焦民生资金、农村集体"三 资"管理、教育医疗、养老助老等重点领域和关键环节，加强监督检查，严肃查处贪污侵占、截留挪 用、虚报冒领、吃拿卡要等侵害群众利益行为。对群众身边不正之风和腐败问题发现一起、查处一起， 对典型案件实行挂牌督办、限时办结，及时通报曝光典型案例，强化警示震慑效应。运用大数据、信息 化等技术手段，提升监督精准度与实效性。 健全长效机制。整治群众身边不正之风和腐败问题是一项长期任务，必须坚持标本兼治、综合治理，建 立健全长效机制，巩固和拓展整治成果。以监督检查与案件查办暴露的问题为导向，制发纪检监察建议 书，深化以案促改、以案促治，深入剖析行业管理制度机制问题，推动提升治理水平。加强新时代廉洁 文化建设，引导基层干部增强廉洁自律意识，筑牢拒腐防变的思想防线。充实基层纪检监察力量，提高 基层纪检监察干部的业务能力和综合素质，为整治群众身边不正之风和腐败问题提供有力保障。（黑龙 江省克山县委常委，县纪委书记、监委主任 宁洪波） 群众身边的不正之风和腐败问题直接损害群众切身利益，侵蚀和挥霍基层群众对党的信任。县级纪检监 察机关应紧盯县乡关 ...

注射类医美丨研究报告 核心摘要： 技术手段与审美认知共同引领医美行业变革。随着医美行业进入发展期，非手术项目选择逐渐丰富，"抗衰 老"成为消费者的核心诉求。注射类轻医美项目为精细化美容塑型提供技术支持，消费者在"变美"基础上更 加追求"自然"。随着新材料的不断出现、及传统材料的不断创新，注射类医美项目丰富度持续提升，满足多 元审美需求，加之其效果明显、恢复期短、可及性强，复购率不断上涨，案例数及市场规模呈现出超越行业 平均的增速。艾瑞认为，注射类医美市场将成为医美领域新蓝海。 注射类医美概念及分类 通过针剂注射实现微创美容，透明质酸和肉毒素二分天下 注射类医美项目是通过针剂注射方式实现微创美容效果的治疗手段，主要分为透明质酸类、肉毒素 类、胶原蛋白类、再生针剂类、溶脂针类和埋植线类。其中，医美注射类市场一直被透明质酸和肉 毒素二分天下，根据 ISAPS 数据， 2023 年全球注射类项目治疗次数排名中，肉毒素以 887.8 万例 居世界第一，玻尿酸以 556.5 万例居世界第二。此外，再生针剂、胶原蛋白针也是近年来的"明星 项目"，受到市场的狂热追捧。埋植线、溶脂针因技术不成熟、安全风险高等原因市场发展较为缓 ...