Rather than take its cues from the Democratic Socialist's win in NYC, the party should look to those who've won in purple states, says @FSbarry (via @opinion) https://t.co/No1GahzVoZ ...

Under the national-security law the authorities have dismantled Hong Kong’s democracy movement. But Leung Kwok-hung remains a totem for Hong Kongers who continue to work for democratic change https://t.co/fqybpsPZC0 ...

Elon Musk"If this insane spending bill passes, the America Party will be formed the next day. Our country needs an alternative to the Democrat-Republican uniparty." https://t.co/Kh11mj6uGc ...

Hong Kong’s Chinese masters have shorn the city of its democracy. Leung Kwok-hung and his supporters offer at least a chance of regrowth https://t.co/9TBOC6saDG ...

[Music] thank you today I'm going to tell you that what most people think about democracy is wrong the prevailing folk theory of democracy goes something like this in a democracy the people are always right the majority determines what's right and wrong and politicians should always just carry out the will of the people and I think we've all been brought up with this very simplistic notion about how our democracy is supposed to work um and the problem it's not true we're about to discuss whether democracies ...

Kenya has grown steadily and sustained a largely peaceful democracy. But now the picture is looking bleak, as people grow discontented and vent their anger in the streets. The country’s leader must change tack https://t.co/2Ce84Qgz23Photo: Imago https://t.co/ImUycbUWZ6 ...

Palazestrant (OP-1250) Development - Olema aims to establish Palazestrant as a best-in-class backbone therapy for ER+/HER2- breast cancer, both as a monotherapy and in combination with other anti-tumor agents[8] - The pivotal Phase 3 OPERA-01 clinical trial of Palazestrant as a monotherapy is ongoing, with top-line results expected in 2026[16, 37] - A pivotal Phase 3 OPERA-02 clinical trial of Palazestrant in combination with ribociclib is planned for initiation in 2025[3, 14, 16, 37, 88] - Palazestrant monotherapy Phase 2 data showed a median PFS of 73 months in 2/3L ±CT ESR1-mutant patients and 55 months in 2/3L ±CT ESR1-wild-type patients[45, 46, 47] - Palazestrant, at 120mg in combination with ribociclib, showed a 6-month PFS rate of 74% in all patients and 68% in patients with prior CDK4/6i[75, 80] OP-3136 (KAT6 Inhibitor) Development - Olema is advancing the clinical development of OP-3136, a potential best-in-class KAT6 inhibitor, in breast and other solid tumor cancers[10] - The FDA has cleared the Investigational New Drug (IND) application for OP-3136, and a Phase 1 clinical trial has been initiated[16, 100] - Preclinical data demonstrates that OP-3136 shows synergistic activity in combination with palazestrant[112] Market and Financial Position - The estimated global market for ER+/HER2- metastatic breast cancer is greater than $20 billion[35] - The U S market potential for Palazestrant in the 2/3L setting is estimated at $3-5 billion[63] - Olema has a strong capital position with $3927 million[13]

As we prepare to celebrate our country's 249th birthday, we are getting new insight into what Americans think about where the country stands. A new NPR PBS News mayor's poll found 34 of Americans feel that democracy is under serious threat and see politically motivated violence as a major problem. So, who better to talk about this moment in time than presidential historian John Meechum.He wrote a new introduction to Random Houses's volume of the Declaration of Independence and the Constitution. So, John, um ...

Continued repression and the absence of a credible opposition may help William Ruto secure another term in the face of widespread unhappiness. Kenya’s reputation as an exemplar of African democracy looks set to suffer further https://t.co/f7zOqKl4WT ...

And so as I take my seat, I just want to say to the American people that no matter what the outcome is on this singular day, what fight forward, we're going to press on. We're going to press on. We're going to press on. We're going to press on for our children. Press on for our seniors.Press on for our veterans. Press on for our unions. Press on for our farmers. Press on for our dreamers. Press on.Press on for workingclass Americans. Press on. Press on for the middle class.Press. Press on for all who aspire ...