Core Viewpoint - The article discusses the rapid development and potential of the biomanufacturing industry, highlighting its role in the Fourth Industrial Revolution and the significant growth opportunities it presents in various sectors, particularly in China [3][4]. Industry Overview - Biomanufacturing is defined as an advanced production method centered on industrial biotechnology, utilizing biological resources and processes to produce target products at scale [5]. - The global biomanufacturing industry is projected to reach approximately $12,190 billion in 2024, with a year-on-year growth of 7.4%, and is expected to exceed $20 trillion by 2030, with a compound annual growth rate (CAGR) of 8.4% [9]. Market Dynamics - In China, the biomanufacturing industry is anticipated to reach a scale of 1.01 trillion yuan in 2024, growing by 15.4%, and is expected to surpass 2.5 trillion yuan by 2030, with a CAGR of 16.8% [9][10]. - The top three segments in China's biomanufacturing industry in 2024 will be biopharmaceuticals, biological food, and bio-chemical products, with biopharmaceuticals remaining the largest segment [10]. Technological Advancements - The industry is experiencing a shift from traditional resource reliance to technology-driven approaches, with significant improvements in biomass resource utilization and equipment efficiency [8]. - Innovations in biopharmaceuticals, such as the development of bispecific antibodies and ADC drugs, have seen an annual growth of 65% in product pipelines [8][12]. Application and Impact - In the medical field, biomanufacturing technologies like 3D printing are enabling personalized implants, achieving gross margins of 75% [9]. - In agriculture, microbial fertilizers have improved corn yields by 12% while reducing chemical fertilizer usage by 30% [9]. Future Trends - The article outlines several key trends, including the restructuring of industrial ecosystems, regional layout changes, deepening technological revolutions, product innovation iterations, and capital factor restructuring [17][18][19]. - The integration of AI and biotechnology is expected to enhance production efficiency and product quality, with significant implications for the industry [18]. Strategic Recommendations - Companies are encouraged to build a three-dimensional competitive system focusing on technology research and development, scene innovation, and ecosystem construction [20]. - Local governments should create a supportive industrial service matrix to foster the growth of the biomanufacturing sector [20].

Group 1 - The swine sector is experiencing a slowdown in the growth rate of breeding stock, with the industry capacity still showing slight inertia growth [1] - The planting sector emphasizes the need for self-sufficiency in food security, aiming to enhance yield through the integration of quality land, seeds, opportunities, and methods, with the commercialization of genetically modified corn expected to accelerate [1] - The pet sector is witnessing the rise of domestic brands through product innovation and refined marketing, while export business continues to grow rapidly [1] Group 2 - The animal health sector faces intense competition in traditional poultry vaccines, while the pet health market is expected to expand continuously due to aging trends [1] - The Livestock ETF tracks the China Securities Livestock Index, which is compiled by China Securities Index Co., and selects listed companies involved in livestock farming and feed processing to reflect the overall performance of the livestock industry [1] - The index constituents cover upstream and downstream enterprises in the livestock industry chain, effectively representing the overall development of the livestock sector [1]

Core Viewpoint - The recent research on "AAV9-mediated gene therapy for infantile Pompe disease" led by Professor Feng Zhichun represents a significant breakthrough in treating this rare genetic disorder, potentially offering a "one-shot cure" solution for patients [1][5]. Group 1: Disease Overview - Pompe disease, also known as Glycogen Storage Disease Type II, is a rare autosomal recessive disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), leading to glycogen accumulation in lysosomes, particularly affecting skeletal, cardiac, and smooth muscles [2][3]. - The infantile form of Pompe disease progresses rapidly, often resulting in heart failure and respiratory failure by the age of one if untreated [2]. Group 2: Current Treatment Limitations - Enzyme replacement therapy (ERT) has been the primary treatment since its introduction in 2006, significantly reducing mortality rates and improving quality of life for some patients; however, it does not penetrate the blood-brain barrier and has limitations in addressing central nervous system involvement [3][4]. - ERT requires bi-weekly administration and can be costly, with some patients developing antibodies that reduce treatment efficacy or cause allergic reactions [3]. Group 3: Gene Therapy Development - The newly developed GC301 injection, utilizing AAV9 as a vector to deliver a codon-optimized human GAA gene, aims to provide a long-lasting solution by correcting the genetic defect and restoring GAA enzyme synthesis [4][5]. - Initial trials with four infants showed promising results, with three achieving significant developmental milestones and improvements in cardiac function within a 52-week observation period [5]. Group 4: Safety and Future Directions - Preliminary findings indicate that GC301 is safe, with no severe immune-related adverse reactions reported; however, ongoing assessments are necessary to evaluate long-term safety and efficacy [6]. - Future research may explore the application of GC301 in late-onset Pompe disease and the development of personalized treatment plans based on different genotypes [7].

经过基因编辑的雌性家蚕在成虫阶段发生了转变，原本7节的腹部变成了雄性特有的8节，长出了雄 蚕才有的抱握器等生殖器官，甚至体内还发育出完整的精囊、输精管，能产生和雄蚕一样的精子。这一 成果标志着家蚕性别控制技术取得重大突破，有望通过该技术培育更高产量和品质的品种，推动丝绸产 业发展。 "这个技术不仅适用于家蚕。"童晓玲表示，研究发现，包括蚊子、棉铃虫和褐飞虱等在内的多种害 虫，其"性别开关"基因都有类似的拼接规则。在害虫防治领域，相关成果也为开发新型害虫控制策略提 供了理论基础，为农业生产的可持续发展提供保障。（记者雍黎） Bmdsx是控制家蚕"性别开关"的关键基因，该基因在雌蚕和雄蚕体内会产生不同"版本"的剪接变 体，雌蚕会不折不扣使用Bmdsx上的E3和E4外显子，发育为雌性特征；雄蚕则会跳过E3和E4发育为雄 性特征。正是关于E3和E4的"舍"与"取"，决定了蚕宝宝最终是雌还是雄。 童晓玲教授介绍，研究团队聚焦控制性别的关键基因，巧妙地使用CRISPR/Cas9基因编辑技术，精 准靶向该基因的雌特异性外显子剪接位点，通过诱导单碱基突变破坏剪接供体/受体位点，强制雌性个 体跳过E3和E4外显子，使雌蚕执行了 ...

腺相关病毒 （AAV） 是目前最常用的体内基因治疗载体，已获准用于治疗包括色素性视网膜炎、脊髓性肌萎缩症、杜氏肌营养不良症和血友病等在内的多种疾 病。 这些人类基因疗法的临床成功取决于腺相关病毒 （AAV） 能否安全有效地转导到多种组织。然而，剂量相关的毒性甚至死亡，以及高剂量相关的转基因表达显著 减弱，促使人们深入理解 AAV 与宿主的相互作用的分子机制。 2025 年 7 月 14 日，北京大学生命科学学院 苏晓东 教授、悉尼大学 Charles G. Bailey 、 John E.J. Rasko 等作为共同通讯作者，在国际顶尖学术期刊 Cell 上 发表了题为： An alternate receptor for adeno-associated viruses 的研究论文。 该研究发现了一种 腺相关病毒 （AAV） 的替代受体—— AAVR2 （CPD） ，其在 缺乏 AAVR 的情况下，可恢复 E 分支 AAV （包括 AAV8） 的转导作 用，并 为未分类的 AAV11 和 AAV12 提供了一条独立于 AAVR 的专属进入通道。此外，研究团队过表达了一个最小的功能性 AAVR2 （miniA ...

Group 1 - The core idea of the news is that Guohua Life actively participated in the "7.8 Insurance Publicity Day" event, promoting financial insurance knowledge while encouraging a healthy lifestyle through a walking event [1][2][11] - The walking event, themed "Love and Responsibility: Insurance Makes Life Better," involved over 100 employees from the headquarters and highlighted the connection between history and the future along a 3-kilometer riverside path [2] - Various branches of Guohua Life also organized similar walking activities, creating a collaborative atmosphere across the company [3][5][9] Group 2 - The Sichuan branch engaged employees in a themed activity that combined walking with the dissemination of financial knowledge to the public [3] - The Henan branch showcased team cohesion and vitality by educating citizens on party history and insurance protection during their walking event [5] - The Qingdao branch participated in a health run, promoting the insurance concept of love and responsibility to fellow runners [7] Group 3 - The Chongqing branch integrated "Red Education + Financial Science Popularization" to enhance public understanding of the insurance industry [9] - The overall initiative aimed to spread financial insurance knowledge and provide warmth and hope to those in need, reflecting the company's social responsibility [11] - Guohua Life is committed to enhancing consumer awareness of financial knowledge and actively participating in social welfare activities [11]

7月12日，在北京金融街宁静的周末，泓德基金官网悄然挂出一则高级管理人员变更公告，原督察长李晓春因退休离任；同日，原副总经理李娇于离任副总 经理一职，转任督察长。李晓春的"退休离任"与李娇的"工作转任"，恰似一组精准咬合的齿轮，平稳完成了督察长职责的交接。然而，这场看似顺畅的人事 更迭背后，却似乎掩不住泓德基金高管团队日渐单薄的底色。 | 基金管理人名称 | 泓德基金管理有限公司 | | --- | --- | | 公告依据 | 《公开募集证券投资基金信息披露管理办 | | | 法》 《证券基金经营机构董事、监事、高 | | | 级管理人员及从业人员监督管理办法》等 | | 高管变更类型 | 新任基金管理公司督察长、离任基金管理公 | | | 司督察长、离任基金管理公司副总经理 | | 新任高级管理人员职务 | 督察长 | | --- | --- | | 新任高级管理人员姓名 | 李娇 | | 是否经中国证监会核准取得高管任职 | | | 资格 | | | 中国证监会核准高管任职资格的日期 | - | | 任职日期 | 2025-07-12 | | | 李娇女士,山东大学经济学硕士学位。2015 年3月加入泓 ...

"党的作风是党的性质、宗旨、纲领和路线的重要体现，是党的创造力、战斗力的重要内容……"在山东能源西北矿业望田煤业机关二楼会议室，一场别开生面、紧扣实际的专题党课，引来阵阵 掌声。 七一前后，该公司以"高质量发展强担当—改革创新当先锋"为主题，扎实开展"讲一堂专题党课、重温一次入党誓词、开展一次党性教育"为主要内容的"三个一"活动，激励党员勇立改革潮头，凝 聚奋进力量，为企业高质量发展筑牢红色根基。 "此次专题党课以详实的行业案例和先进经验，深入剖析作风建设与企业高质量发展的内在关联，为全体党员注入了思想动力。"该公司党群工作部组织干事刘志中说。 思想教育是激发党员活力、推动企业发展的重要抓手。该公司以专题党课为载体，扎实推进思想教育走深走实。他们组织党员领导班子成员下沉至联系点党支部，各党支部书记深入所在支部， 围绕深入贯彻中央八项规定精神学习教育，紧密结合煤矿安全生产、降本增效、一级标准化矿井验收等工作实际，灵活采用授课与现场互动相结合的"微党课"形式开讲。截至目前，已累计开展 专题党课15场，围绕"怎样以作风建设为抓手破解企业发展难题"等议题，收到合理化建议31条，切实让党的理论与企业发展需求深度融合，为 ...

撰文丨王聪 编辑丨王多鱼 排版丨水成文 自然界中存在着多种生殖方式，除了 有性生殖 ，还有些动植物能够进行 孤雌生殖、 孤雄生殖 。但是对于高等的哺乳动物来说，只能进行 有性生殖 ，每一个 哺 乳动物生命都始于卵子与精子融合形成的受精卵，其中包含两套基因组，一套来自母亲，一套来自父亲。然而，有些基因只有来自父亲的等位基因表达，有些则 只有来自母亲的等位基因表达，也就是所谓的 基因组印记 ，这种基因组印记是通过表观遗传学的甲基化实现的，基因组印记的存在，阻碍了孤雌生殖或 孤雄生 殖 的实现。 近日，上海交通大学医学院附属仁济医院生殖医学中心 魏延昌 等人在《 美国国家科学院院刊 》 （PNAS） 上发表了题为： Fertile androgenetic mice generated by targeted epigenetic editing of imprinting control regions 的研究论文。 在这项新研究中，研究团队报告了由两个精子细胞的遗传物质培育出的成年哺乳动物后代。研究团队将这些小鼠称之为孤雄生殖小鼠，是通过基于 CRISPR 的表 观基因组工程对 7 个印记控制区域 （ICR） ...

Investment Rating - The industry rating is maintained as "Increase" [4] Core Views - In the second quarter of 2025, the average price of live pigs is expected to be 14.5 CNY/kg, a decrease of 4.6% from the previous quarter and 11.4% year-on-year. However, due to the decline in raw material prices and improved breeding performance, listed companies are optimizing costs [15][16] - The poultry sector is facing challenges, with yellow feathered chicken prices remaining low at an average of 11.3 CNY/kg, down 2.4% quarter-on-quarter and 15.5% year-on-year. The profitability of leading companies like Wen's Group may be under pressure due to these price declines [15][16] - The feed sector is benefiting from stable pig prices and rising aquatic product prices, with Haida Group expected to achieve a feed sales volume of approximately 13.65 million tons in the first half of 2025, a year-on-year increase of about 26% [15][16] Summary by Sections Livestock Farming - The national price of lean meat pigs is 14.54 CNY/kg, down 2% from last week. The current valuation remains relatively low, with a focus on leading companies and low-cost high-growth targets such as Muyuan Foods and Wen's Group [2][16] - The average price of white feathered chickens is 6.24 CNY/kg, down 7.6% from last week, while chicken product prices average 8.38 CNY/kg, down 0.9% [16][30] - The price of parent stock chicken chicks is 47.2 CNY/set, up 1% week-on-week, while the price of meat chicken chicks is 0.99 CNY each, down 27.2% [26][28] Feed Sector - Haida Group is expected to achieve a net profit of 1.218-1.518 billion CNY in the second quarter, with a year-on-year change of -3.64% to +20.1% [15][16] - The pet feed industry continues to maintain high growth, with expectations for Zhongchong Group to achieve a net profit of approximately 120 million CNY in the second quarter, a year-on-year increase of about 40% [15][16] Agricultural Products - The approval of genetically modified varieties is expected to lead to commercial sales, with potential growth for industry companies as actual transaction prices and profit distribution are confirmed [16] - The fluctuation of agricultural product prices is increasing, and leading feed companies are expected to replace smaller companies due to their advantages in procurement, scale, and capital [16]