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“减重效果比司美格鲁肽高近50%”!
第一财经· 2025-05-12 03:05
美国当地时间5月11日,礼来在《新英格兰医学杂志》(NEJM)上最新发表了GIP/GLP-1双受体激 动剂替尔泊肽与GLP-1单受体激动剂司美格鲁肽的一项"头对头"对照研究的详细结果。数据显示,替 尔泊肽与司美格鲁肽相比实现了1.47倍的相对体重减轻。 这项被命名为SURMOUNT-5的三期大规模临床研究旨在评估在肥胖或伴有至少一种合并症(如高血 压、血脂异常、阻塞性睡眠呼吸暂停、心血管疾病)的超重成人(且不合并糖尿病),使用替尔泊肽 与司美格鲁肽的有效性与安全性。在用药第72周时,替尔泊肽组患者平均减重20.2%,司美格鲁肽组 患者平均减重13.7%。这表明替尔泊肽的减重效果要比司美格鲁肽高出近50%。 数据还显示,在该研究的关键次要终点中,替尔泊肽在所有减重目标中均优于司美格鲁肽。替尔泊肽 组实现体重减轻≥15%的参与者比例达64.6%,而司美格鲁肽组为40.1%;替尔泊肽组平均腰围减少达 18.4cm,而司美格鲁肽组为13.0cm。 美 国 威 尔 康 奈 尔 医 学 院 综 合 体 重 控 制 中 心 主 任 、 该 研 究 的 主 要 研 究 者 路 易 斯 · 亚 隆 ( Louis J. Aro ...
替尔泊肽“大战”司美格鲁肽!减重效果高近50%
Di Yi Cai Jing Zi Xun· 2025-05-12 02:31
全球最主要的两款GLP-1减重药的竞争正在进入白热化。 中国是继美国之后,减重药厂商争夺的下一个巨大市场。据礼来援引一项发表在《Obisity》杂志的数 据,目前中国已有超5亿成人受到超重和肥胖影响,而肥胖与224余种慢性疾病相关。预计到2030年,肥 胖相关医疗支出将占国家医疗费用总额的22%左右。 美国当地时间5月11日,礼来在《新英格兰医学杂志》(NEJM)上最新发表了GLP/GLP-1双受体激动剂 替尔泊肽与GLP-1单受体激动剂司美格鲁肽的一项"头对头"对照研究的详细结果。数据显示,替尔泊肽 与司美格鲁肽相比实现了1.47倍的相对体重减轻。 这项被命名为SURMOUNT-5的三期大规模临床研究旨在评估在肥胖或伴有至少一种合并症(如高血 压、血脂异常、阻塞性睡眠呼吸暂停、心血管疾病)的超重成人(且不合并糖尿病),使用替尔泊肽与 司美格鲁肽的有效性与安全性。在用药第72周时,替尔泊肽组患者平均减重20.2%,司美格鲁肽组患者 平均减重13.7%。这表明替尔泊肽的减重效果要比司美格鲁肽高出近50%。 数据还显示,在该研究的关键次要终点中,替尔泊肽在所有减重目标中均优于司美格鲁肽。替尔泊肽组 实现体重减轻≥ ...
睡眠不足会导致肥胖?如何改善睡眠助力减重
Xin Hua Wang· 2025-05-11 13:30
西南医院呼吸内科主治医师黄晓寒表示,睡眠不足还会导致生理压力增加,引发慢性炎症反应。此 时身体可能启动保护机制,通过蓄积水分、储存能量来应对压力,进而导致水肿和脂肪合成增加。长此 以往,可能诱发阻塞性睡眠呼吸暂停综合征,威胁身体健康。 专家建议,保持健康体魄需要充足睡眠。"刚会走路的小孩每天建议睡眠时间应保持在11至14小 时,学龄儿童在9至11小时,成年人为7至9小时,65岁以上的人为7至8小时。"黄晓寒说。 专家同时建议,可通过一些方法来改善睡眠。"如创造一个舒缓的入睡程序。睡前一小时开始进入 程序,先把第二天要做的事情整理好,房间内保持安静,关掉电视、电脑等电子设备。通过听舒缓的音 乐、阅读或泡澡等方式让身心放松。此外,建议睡前不宜吃太多食物。保持房间凉爽和舒适,同时经常 换洗床上用品。"黄晓寒说。 "肥胖是指长期能量摄入超过消耗,导致脂肪过度蓄积的状态。"西南医院内分泌科副主任周丽娜介 绍,肥胖会损害心血管系统,过多脂肪堆积会增加心脏负担,导致血压升高、血脂异常;血液中过高的 胆固醇和甘油三酯易在血管壁形成斑块,引发动脉粥样硬化,进而增加冠心病、高血压等疾病风险。 "在众多导致肥胖的因素中,睡眠是较为 ...
在中国肥胖日 见证一场三甲医院里的“脂肪攻坚战”
Xin Hua Wang· 2025-05-11 03:56
沈奇伟带领医院职工一同锻炼。新华社记者 许东远 摄 新华社上海5月11日电(记者袁全、许东远)"工作太忙,没时间运动。""下班了,我只想'躺平'。""外卖热量高?但我不想自己做饭。"这些困扰 现代人的减肥难题,同样存在于医生的白大褂之下。 5月11日"中国肥胖日"前夕,记者走进复旦大学附属华山医院,为应对忙碌的日常中难以避免的"过劳肥",这里的医护人员选择以科学为盾、以互 助为矛,在院内一个名为"30斤俱乐部"的组织中开启了一场自我革新的健康之战。 清晨7点15分,记者来到华山医院浦东院区的运动康复中心,"30斤俱乐部"的招牌下已聚集了十余名身着白大褂或洗手衣的医护人员。运动医学科 主管技师孙扬手持计时器,一边催促同事加快动作,一边示范着标准姿势:"大家抓紧时间动起来,门诊开始前准时结束!"热身、拉伸、哑铃训 练……平日手术台上沉稳干练的医生们,此刻在瑜伽垫上发出阵阵"惨叫"。"坚持住,还有两组!"孙扬的鼓励声夹杂着喘息,汗水浸透的T恤成了 这群"减肥战友"无声的勋章。 这场每周雷打不动的晨练,源自两位外科医生"化脂肪为友谊"的奇妙碰撞。 "前几年忙到没时间关注身体,体重飙升,体检指标全亮红灯。"肥胖疝外科副 ...
“体重管理”消费热潮应需而起 减重、健身成拉动消费增长新引擎
Yang Shi Wang· 2025-05-11 03:04
央视网消息:5月11日是"世界防治肥胖日",防治肥胖事关健康,运动是健康减肥的重要途径。在山东济南,24小时健身房、室内攀岩等各类 健身场所不断涌现,"减重经济"也跟着一路升温。 中午12时是午饭时间,但在这家健身房里,不少人正抓紧锻炼。 随着健身房的人气高涨,不少健身房开始延长营业时间,推出24小时营业服务。晚上十点多,这家24小时健身房内仍有不少人在健身。 消费券的惠民效果显著。"五一"假期,超千名宁波市民在市全民健身中心使用消费券,累计节省金额达1.7万多元。宁波市体育发展中心发放 的6.5万元免费畅动券,也让更多人轻松走进场馆,享受运动的快乐。 体重管理消费热潮带火健身用品 此外,一些新的健身场景也激发了市民参与的热情。在济南某综合商场里,不少人正在体验室内攀岩。作为新兴运动项目,室内攀岩难度可调 节,训练时间灵活,一经推出就备受青睐。 据统计,目前济南市共有各类健身房相关企业1.42万家。不少商家通过升级服务来吸引消费者,"减重""健身"正逐渐成为拉动消费增长的新引 擎。 运动场馆人气旺 发放补贴促消费 在浙江宁波,运动场馆的火爆人气同样让"减重经济"持续升温。 在宁波市全民健身指导中心羽毛球馆,8 ...
中华预防医学会:七成大众有体重管理意识
Xin Hua She· 2025-05-11 01:10
中华预防医学会副会长梁晓峰表示,这种认知偏差导致心脑血管疾病、糖尿病等慢性病防控难度加大, 肥胖相关健康危害的科普仍需下沉。 体重管理意识初步显现,半数大众自评目前有超重风险,七成大众有体重管理的意识、希望改善体重, 超六成愿为体重管理付出努力,投入时间和精力……《成人健康体重管理白皮书(2025)》5月10日在 广东佛山举行的第二届中国肥胖防控大会上发布,呼吁社会关注科学减重。 据介绍,白皮书由中华预防医学会联合暨南大学等开展针对体重管理大众实践情况的调研编制而成。内 容分为大众体重管理认知意识篇、大众体重管理实践行动篇、大众体重管理未来期望篇等部分。 国家卫生健康委发布的《体重管理指导原则(2024年版)》指出,我国成人超重率和肥胖率分别为 34.3%和16.4%,若不加以控制,2030年成人超重肥胖率将达到70.5%。同时,2030年超重肥胖相关医疗 费用预计将达到610亿美元,占全国医疗保健支出的22%。 白皮书显示,我国50%成人自评体重与实际身体质量指数(BMI)不符,其中19%的人虽自评为超重或 肥胖,其BMI指数却处于正常范围,14%的人认为自己体重处于健康状态,可实际上BMI指数已达到超 重 ...
减重赢奖金?《西虹市首富》剧情照进现实!网友:我能赚套房
Sou Hu Cai Jing· 2025-05-03 03:50
Core Viewpoint - JD Health's initiative "Happy Weight Loss" offers cash rewards for weight loss, responding to the rising obesity rates in China, where over 50% of adults are overweight [3][5] Group 1: Company Initiatives - JD Health's instant retail business launched a weight loss challenge, rewarding participants with 100 yuan for every kilogram lost [1][3] - The challenge has sparked discussions on social media, with some users viewing it as a quick way to earn money [3][5] Group 2: Product Development - Chinese scientists have developed a weight loss product called AKK 001, which targets gut health to improve metabolism [8][10] - The product has gained popularity on platforms like JD and Watsons, with significant sales growth [8][14] Group 3: Consumer Demographics - The primary consumers of AKK 001 are middle-aged men aged 30-50 from first and second-tier cities, accounting for 80% of orders and repurchases [14][16] - Users report significant weight loss and improved body metrics after using the product, leading to increased community engagement around weight loss [14][16] Group 4: Market Trends - The rise of health consciousness and body management needs is driving the "weight loss economy" as a new consumer trend [17] - Other companies are also launching weight loss initiatives, such as Meituan's "no weight loss, no compensation" policy and Decathlon's fitness challenges [17][19] Group 5: Expert Insights - Experts emphasize the importance of a scientific and sustainable approach to weight loss, combining products with exercise and dietary adjustments for long-term success [19]
低糖减重营养好 五月必吃的6种水果你得这么挑
Yang Shi Xin Wen· 2025-05-02 03:59
今天为大家准备了一份5月水果必吃榜,不仅覆盖我国南北时令水果,而且都是滋味甜美、含糖量不高,可以放心 炫的"报恩"水果。(以下排名不分先后) 第一位:枇杷 上榜理由:热量低、血糖友好、抗氧化、保护眼睛、补水通便。 五月一到,天气越来越暖,各色水果也都逐渐上市,让人忍不住馋虫大动。这个季节到底该选择哪些水果,又应 季、又好吃,还健康有营养呢? 热量低 枇杷虽为亚热带水果,但热量仅41千卡/100克,低于苹果、梨等常见水果。 血糖友好 枇杷清甜但含糖量仅9.3克/100克,血糖生成指数不超过55,属于低血糖生成指数水果,需要控制血糖的朋友也可 以吃。 抗氧化、保护眼睛 枇杷类胡萝卜素含量为300~4400微克/100克,颜色越深含量越高。能抗氧化,还能保护眼睛和皮肤,有益于对抗 干眼症、眼疲劳。 补水通便 枇杷鲜果水分可高达92%,还含有增加粪便体积、促进肠道蠕动的山梨糖醇,有助于润肠通便。 选好枇杷有技巧: 1.表皮有绒毛。枇杷表皮的绒毛在运输和储存过程中会受损伤,因此绒毛越完整,说明运输、存储损伤小,且新 鲜度更高。 2.颜色橙红、橙黄。表皮完好、新鲜的情况下,颜色越深成熟度越高,也越发香甜。 3.果形椭球、 ...
专家:长期吃生冷食物和“苦夏减重”均不可取
Zhong Guo Xin Wen Wang· 2025-05-01 01:08
Core Viewpoint - The article emphasizes the importance of maintaining a balanced diet and avoiding cold foods, particularly during the summer season, to support digestive health and overall well-being [3]. Group 1: Health Recommendations - Long-term consumption of cold foods like ice cream and cold drinks is detrimental to digestive health, leading to symptoms such as poor appetite, diarrhea, and abdominal pain [3]. - The concept of "bitter summer" is described as a state of discomfort due to heat, and attempting to lose weight during this period is not advisable as it can lead to nutritional deficiencies and a decrease in metabolism [3]. - It is recommended to consume warm foods such as leeks and seasonal vegetables, and to follow traditional practices like "eating ginger in summer" to support digestive health [4]. Group 2: Individual Differences - There are individual and regional differences in dietary habits, with many Western individuals being more accustomed to cold foods due to their high-calorie and high-protein diets [3]. - The article highlights that each person's constitution varies, which affects their ability to tolerate cold foods [3].
医药行业周报:医药交易创新高,关注临床数据发布
Huaxin Securities· 2025-04-27 14:23
Investment Rating - The industry investment rating is "Recommended" (maintained) [1] Core Viewpoints - The pharmaceutical industry in China has seen a significant increase in transaction volume and value, with Q1 2025 showing a 34% year-on-year increase in transaction numbers and a 222% increase in total transaction value, establishing China as a key player in global pharmaceutical transactions [3] - There is a substantial market potential for gout and uric acid-lowering treatments, with the number of patients in China expected to rise from 170 million in 2020 to 240 million by 2030, highlighting the need for safer and more effective medications [4] - Antibody-drug conjugates (ADCs) and bispecific antibodies are emerging as significant advancements in drug development, with potential to become first-line treatments in oncology as clinical data continues to support their efficacy [6] - The oral weight-loss drug market is poised for growth, with companies like Novo Nordisk and Eli Lilly making strides in developing oral GLP-1 receptor agonists, presenting opportunities for Chinese biotech firms to enter the market [8] - Recent price increases in raw materials, particularly in the pharmaceutical sector, indicate a shift in supply dynamics, with certain products experiencing significant price hikes due to changes in competitive relationships [10] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry outperformed the CSI 300 index by 0.77 percentage points over the past week, with a weekly increase of 1.16% [24] - Over the past month, the industry also outperformed the CSI 300 index by 1.51 percentage points, with a monthly increase of 5.31% in the chemical pharmaceutical sub-sector [27][34] 2. Pharmaceutical Sector Trends and Valuation - The pharmaceutical sector's recent one-month decline was 2.19%, but it outperformed the CSI 300 index by 1.51 percentage points [43] - The current price-to-earnings ratio (PE) for the pharmaceutical sector is 30.67, which is below the five-year historical average of 32.78 [48] 3. Recent Research Achievements - The research team has published several in-depth reports on various aspects of the pharmaceutical industry, including the growth of blood products and the impact of policy support on inhalation formulations [52] 4. Important Industry Policies and News - Recent policies include a three-year initiative to improve pediatric and mental health services, and a plan for the digital transformation of the pharmaceutical industry from 2025 to 2030 [55] - Notable industry news includes multiple companies receiving approvals for new drug applications and significant clinical trial results being presented at the upcoming ASCO conference [56][57]