Pfizer (PFE) FY Conference June 09, 2025 08:00 AM ET Speaker0 Great. Good morning, everyone, and welcome to our forty sixth Annual Global Healthcare Conference. My name is Assad Heather. I'm The U. S. Pharma Analyst here at Goldman Sachs. And we are very privileged to have Albert Bula with us to kick up this conference. Albert's the CEO of Pfizer. Albert, thank you for being with us. Speaker1 Great pleasure. Speaker0 Albert, we have about thirty five minutes, so I wanna start with a big picture question for ...

Core Viewpoint - Addex Therapeutics announced significant anti-tussive activity of its GABAB positive allosteric modulator (PAM) in preclinical models, indicating potential as a treatment for chronic cough [1][3][4] Company Overview - Addex Therapeutics is a clinical-stage biopharmaceutical company focused on developing novel small molecule allosteric modulators for neurological disorders [6] - The company’s lead drug candidate, dipraglurant, is being evaluated for brain injury recovery [6] - Addex has a partnership with Indivior for a GABAB PAM drug candidate aimed at substance use disorders, which has completed IND enabling studies [6] Product Development - The GABAB PAM drug candidate demonstrated significant reductions in cough frequency and increased cough latency in preclinical models, outperforming reference drugs like nalbuphine, baclofen, and codeine [3][4] - The candidate showed better tolerability and a wider therapeutic margin compared to nalbuphine and baclofen, while being comparable to a P2X3 inhibitor [3] - The company is preparing to advance the GABAB PAM candidate into IND enabling studies following positive in vivo proof of concept [4] Scientific Background - GABAB receptors are crucial in the cough neural circuit, and activating these receptors has been clinically validated with baclofen, which has limitations due to side effects and loss of efficacy [5] - The allosteric modulation approach offers advantages such as higher selectivity and better tolerability compared to traditional orthosteric compounds [5]

Key Takeaways JPM is adding 14 new Financial Centers and plans to double its total to 32 locations by 2026. The bank plans to open 500 more branches by 2027 to deepen relationships and boost cross-selling. JPM shares are up 10.3% YTD, outperforming BAC and PNC, despite a projected 2025 earnings decline.JPMorgan (JPM) , the largest U.S. bank, is doubling down on physical expansion to strengthen its competitive edge in relationship banking. With 4,975 branches as of March 31, 2025, more than any other U.S. ...

ATLANTA, June 04, 2025 (GLOBE NEWSWIRE) -- Gray Media, WVUE (New Orleans, Fox 8) and the Saints have entered into a five-year extension to their long-standing broadcast partnership through the conclusion of the 2029 NFL season. The extension kicks off with all three 2025 preseason games starting August 10, when the Saints travel to Los Angeles to take on the Chargers. Extending this agreement cements the bond among Gray Media, WVUE, and the Saints, re-enforcing their shared commitment to providing the commu ...

Core Insights - AT&T, Inc. has outperformed the Wireless National industry and broader market indices, gaining 52.2% over the past year compared to the industry's 27.6% and the S&P 500's 12.1% [1][7] - The company is focusing on broadband innovation and strategic acquisitions to drive long-term growth while managing debt and maintaining dividend payments [3][5] Company Performance - AT&T has outperformed competitors such as Verizon Communications Inc. and T-Mobile US, with Verizon gaining only 6.1% and T-Mobile 36.6% during the same period [2] - The company is experiencing a downtrend in earnings estimate revisions, with 2025 estimates declining by 3.27% to $2.07 and 2026 estimates decreasing by 0.88% to $2.24 [10] Strategic Initiatives - AT&T plans to acquire Lumen's fiber connectivity business for $5.75 billion, which will add 1 million fiber customers and 4 million fiber locations, enhancing its competitive position in the fiber broadband market [5] - The company aims to expand its fiber network to approximately 60 million locations by 2030, nearly doubling its current reach [5] Technological Advancements - AT&T is adopting prpl Foundation's Life Cycle Management (LCM) to enhance broadband innovation, with around 12 million broadband gateways currently integrated with LCM [3][4] - The prplware software optimizes application deployment on broadband gateways, improving efficiency and supporting multi-carrier application deployment [4] Financial Metrics - As of March 31, 2025, AT&T had $6.88 billion in cash and cash equivalents against long-term debt of $117.26 billion, indicating a current ratio of 0.7, which suggests potential challenges in meeting short-term obligations [8] - The company's shares trade at a price/earnings ratio of 13.04, lower than the industry average of 13.72 but above its historical mean of 10.16 [11] Market Challenges - The U.S. wireless market is saturated, leading to a spectrum crunch that complicates mobile data traffic management for carriers [9] - Intense competition from industry giants like Verizon and T-Mobile is impacting AT&T's margins and growth potential [9][14]

Key Takeaways ASTS shares declined 15.6% in three months, underperforming the industry and rivals AVNW and CMTL. Disappointing Q1 results and macro headwinds are hurting ASTS' performance and investor sentiment. ASTS launched five Bluebird satellites and secured deals with ATAST SpaceMobile, Inc. (ASTS) has plunged 15.6% over the past three months against the industry’s growth of 2.8%. It has also underperformed its peers like Aviat Networks, Inc. (AVNW) and Comtech Telecommunications Corp. (CMTL) over th ...

Press ReleaseNokia selected by City of Elberton to modernize broadband network and move from cable to 25G future City of Elberton, Georgia, selects Nokia and partner ZCorum to update its aging cable broadband infrastructure and create a next-generation, 25G PON-ready fiber network.Deployment marks a new digital chapter for Elberton, providing enhanced connectivity that will power the community’s education, healthcare, remote workforce and local innovations. Nokia next-generation fiber and IP solutions help ...

TYSONS, Va., June 03, 2025 (GLOBE NEWSWIRE) -- TEGNA Inc. (NYSE: TGNA) today announced its stations received 59 Regional Edward R. Murrow Awards. TEGNA stations garnered three in overall excellence, the highest achievement awarded, including KING in Seattle which received 11 awards total in the large market television category. “We are delivering impactful journalism that empowers communities with the information, resources and tools they need to thrive,” said Adrienne Roark, chief content officer, TEGNA. “ ...

Leading broadband provider's impressive twelfth national win reflects a sustained commitment to exceptional workplace practices and employee success ENGLEWOOD, Colo., June 3, 2025 /PRNewswire/ -- WOW! Internet, TV & Phone (NYSE: WOW), a leading broadband services provider, was named a 2025 Best and Brightest Company to Work For in the Nation® for the twelfth time, and eighth consecutive year, by the National Association for Business Resources (NABR). WOW!'s people-first approach and thoughtful programs and ...

Core Insights - Harmonic announced a collaboration with CUJO AI to integrate network intelligence software with its cOS virtualized broadband platform, enhancing broadband experiences for latency-sensitive applications like online gaming and video conferencing [1][3] - The integration aims to provide ultra-low-latency broadband at scale, addressing the evolving demands of modern households [2] - The solution combines Harmonic's Low Latency, Low Loss, Scalable throughput (L4S) capabilities with CUJO AI's software, enabling real-time detection and prioritization of latency-sensitive applications [3] Company Overview - Harmonic's cOS platform powers over 33 million customer premises equipment (CPE) devices globally, serving leading operators across North America, Europe, Latin America, and Asia [6] - The company is recognized as a leader in virtualized broadband and video delivery solutions, enabling flexible deployment of gigabit internet services [7] - Harmonic's innovative approach simplifies OTT video delivery and enhances the monetization of live and on-demand content for media companies and service providers [7] Product Features - The integration allows operators to activate L4S capabilities across existing DOCSIS and fiber networks through a simple software upgrade, avoiding major infrastructure investments [4] - The collaboration is positioned to reduce churn, boost retention, and improve average revenue per user (ARPU) while attracting new subscribers with a differentiated offering [3][5] - Harmonic will demonstrate the integration at ANGA COM 2025, showcasing the benefits of the new solution [5]