Core Insights - Oncotelic Therapeutics has published a peer-reviewed research article identifying TGFB2 gene methylation as a positive prognostic biomarker for pancreatic ductal adenocarcinoma (PDAC) [1][2] - The study highlights the potential of TGFB2 methylation to improve overall survival in patients with low CD8+ T-cell infiltration [2][3] Group 1: Research Findings - PDAC is characterized as one of the most lethal cancers with limited treatment options, primarily relying on cytotoxic regimens like FOLFIRINOX [2] - High TGFB2 methylation combined with low expression of immune markers such as CD3D, LCK, and HLA-DRA correlates with a median overall survival exceeding 50 months [3] - The study emphasizes the need to profile TGFB1, TGFB2, and TGFB3 methylation to better understand tumor immune status and select candidates for immunotherapy in resistant "cold" tumors [4] Group 2: Company Commentary - Dr. Sanjive Qazi, the lead author, stated that the discovery enhances understanding of the TGFB gene complex in PDAC, particularly in immunologically cold tumors, supporting further clinical development of OT-101 [5] - Scott Myers highlighted the role of the AI-powered chatbot platform PDAOAI in accelerating scientific discovery through literature mining and analysis [5] - Dr. Michael Potts noted that large language models like PDAOAI are transforming the identification and interpretation of biomedical insights [5] Group 3: Company Background - Oncotelic Therapeutics, originally formed as OXiGENE, Inc. in 1988, has undergone several name changes and is focused on oncology drug development, particularly for rare pediatric cancers [7] - The company has a 45% stake in GMP Biotechnology Limited, which is involved in the development of therapies for various cancers, including Diffuse Intrinsic Pontine Glioma (DIPG) and Acute Myeloid Leukemia (AML) [7] - Oncotelic also acquired PointR Data Inc. to build an AI-driven biotechnology company, further expanding its capabilities in drug development [7]

RT Robby Stein (@rmstein)AI Mode is coming to India – our first international expansion! Labs users in India can now start testing our most powerful AI search, designed to help with your toughest questions. Exciting times ahead for Search … stay tuned for more this summer. ...

With just one subscription to Beyond the Wall Investing , you can save thousands of dollars a year on equity research reports from banks. You'll keep your finger on the pulse and have access to the latest and highest-quality analysis of this type of information.So far, I've written 4 articles on AppLovin Corporation (NASDAQ: APP ) stock here on Seeking Alpha, initially rating it as a "Hold" because of seemingly overheated multiples and some concerns over its prospects, but then eventually upgrading it to "B ...

Ipsos completes the acquisition of The BVA Family Paris, 24 June 2025 - Ipsos, one of the world's leading market research companies, has completed the acquisition of The BVA Family. The operation was concluded after fulfilling all necessary regulatory requirements, including in-depth consultation with employee representatives in France and obtaining relevant competition authority approvals. This acquisition is a significant expansion for Ipsos in France and adds new strength in the UK and Italy. BVA notably ...

TORONTO, June 24, 2025 (GLOBE NEWSWIRE) -- Rockcliffe Capital is pleased to announce today the initiation of equity research coverage on Wheaton Precious Metals Corp. (TSX/NYSE: WPM), the world's premier precious metals streaming company known for its top-tier asset portfolio, strong balance sheet, and robust cash flow generation. Following extensive operational and fundamental analysis, Rockcliffe Capital’s research team highlights Wheaton’s unique position in the global metals streaming sector, underpinne ...

在2025年的AI Agent探索浪潮中，"深度研究"类产品可以说是最早成功落地的一批。 从2024年底谷歌发布其首个深度研究产品开始，短短数月内，OpenAI、Anthropic等行业巨头迅速跟进，推出了功能强大的商业竞品；OpenDeepResearcher、 HKUDS/Auto-Deep-Research、Camel-AI/OWL、OpenManus等明星项目构成的繁荣开源社区也拔地而起。至今，已有超过80个团队投身于此。 经过一段时间的探索，这个领域已积累了相当规模和丰富的实践经验，形成了多样的技术路线和架构选择，整个探索格局已经初步成型。因此，现在正是对这一领 域进行一次系统性梳理和总结的最佳时机。 最近，来自浙江大学的学者撰写了一篇综述，《A Comprehensive Survey of Deep Research: Systems, Methodologies, and Applications》，为我们提供了一整套理解、评 估和展望该领域的认知框架。 文章揭示，当前深度研究系统的生态已经呈现出显著的差异化，竞争的焦点不再是单一的模型能力，而是系统架构、工程优化与应用场景适配度的综合比拼。 ...

SAN DIEGO, June 23, 2025 (GLOBE NEWSWIRE) -- Robbins LLP reminds stockholders that a class action was filed on behalf of all investors who purchased or acquired Reddit, Inc (NYSE: RDDT) securities between October 29, 2024 and May 20, 2025. Reddit is a social media platform and forum-style website where users share and discuss content through posts and comments. For more information, submit a form, email attorney Aaron Dumas, Jr., or give us a call at (800) 350-6003. The Allegations: Robbins LLP is Investiga ...

TORONTO, June 23, 2025 (GLOBE NEWSWIRE) -- Rockcliffe Capital is pleased to announce today the initiation of equity research coverage on Agnico Eagle Mines Ltd. (TSX/NYSE: AEM), a premier senior gold mining company with operations spanning Canada, Finland, Australia, Mexico, and the U.S.  Following rigorous financial and operational analysis, Rockcliffe Capital assigns Agnico Eagle a "Strong Buy" rating, alongside a 12-month price target of US$155, reflecting strong upside potential of approximately 25% fro ...

Group 1 - Moretus Research provides high-quality equity research focused on U.S. public markets, aiming to deliver clarity, conviction, and alpha for serious investors [1] - The research framework identifies companies with durable business models, mispriced cash flow potential, and intelligent capital allocation, emphasizing a structured and repeatable approach [1] - Valuation methods are based on sector-relevant multiples tailored to each company's business model and capital structure, prioritizing comparability, simplicity, and relevance [1] Group 2 - Research coverage focuses on underappreciated companies experiencing structural changes or temporary dislocations, where disciplined analysis can yield asymmetric returns [1] - Moretus Research aims to elevate the standard for independent investment research by providing professional-grade insights and actionable valuation [1]

NEW YORK, June 20, 2025 (GLOBE NEWSWIRE) -- Attorney Advertising -- Bronstein, Gewirtz & Grossman, LLC, a nationally recognized law firm, notifies investors that a class action lawsuit has been filed against Reddit, Inc. (“Reddit” or “the Company”) (NYSE: RDDT) and certain of its officers. Class Definition This lawsuit seeks to recover damages against Defendants for alleged violations of the federal securities laws on behalf of all persons and entities that purchased or otherwise acquired Reddit securities ...