Economic & Social Commentary - Large-scale innovations, particularly in contract law, property law, and financial markets, have historically benefited economies [2] - Over-emphasis on large scales in politics and economics, especially through remote trust-based institutions like governments and global corporations, has contributed to cultural issues [3] - Focus should shift towards smaller social scales, such as families and local communities, rather than solely prioritizing GDP and economic productivity [5] - Reducing reliance on trust in strangers at large social scales is crucial, achieved through verification and nonviolent security, alongside refocusing on smaller social scales [4] - The text advocates for fewer large corporations and governments, and more emphasis on families and local communities with shared understandings and traditions [6] - Protecting long-standing religions and non-commercial traditions from disruptions caused by corporations, governments, and globalization is essential [6] Blockchain & Trust-Minimized Institutions - Trust-minimized institutions at a global scale, leveraging blockchains, smart contracts, and AI, can further improve global economies [2] Risks & Mitigation - Corporatism and large-scale socialism are presented as undesirable extremes, akin to navigating dangerous waters [1] - The text warns against the damages inflicted by strangers, businessmen, and politicians, emphasizing the need to protect communities from disruptions caused by globalization, immigration, and other factors [6]

Technology Updates - Kusama Asset Hub 将很快实现 2 秒区块 [1] - Polkadot 也将在短期内实现 2 秒区块 [1] - Solidity 智能合约将在 Kusama 和 Polkadot 上运行 [1]

Core Insights - Wellgistics is positioned to lead in the Web 3.0 Health Information Data Transfer within the $634 billion prescription drug industry through an exclusive licensing agreement with Datavault AI [1][2][6] - The implementation of Wellgistics' EinsteinRx AI hub is expected to optimize automated prescription fulfillment for various stakeholders including manufacturers, pharmacies, and patients [1][4][6] - Datavault's intellectual property enables smart contracts that create a barrier to entry in the $4.9 trillion US healthcare market [1][2] Company Overview - Wellgistics Health, based in Tampa, Florida, specializes in optimizing medication delivery from manufacturers to patients, connecting over 6,500 pharmacies and 200 manufacturers [3][9] - The PharmacyChain initiative aims to digitize the tracking of prescription drugs, ensuring accurate delivery and recommendations for safe use [3][5] Technology and Innovation - The completion of the EinsteinRx AI hub integrates Wellgistics' IT and physical infrastructure, enhancing the efficiency of prescription fulfillment and reducing costs associated with pharmacy benefits managers (PBMs) [4][5][6] - Wellgistics aims to minimize or eliminate PBM rebates, thereby reducing administrative burdens for payers and improving the overall pharmaceutical distribution process [6][7] Market Potential - PwC estimates a $1 trillion opportunity to shift healthcare spending towards a digital-first, proactive, and personalized system [2] - The integration of smart contracts into Wellgistics' operations is expected to significantly improve cost efficiency in the prescription filling process, benefiting various stakeholders in the healthcare ecosystem [6][7]

Core Insights - Cardano (CRYPTO: ADA) is a well-structured cryptocurrency project with significant potential, but it struggles to attract users to its ecosystem [1] - As of November 24, Cardano was trading at $0.43, down approximately 58% year over year from its peak of $3.10 over four years ago [2] Group 1: Image and Market Position - Cardano faces an image problem, lacking the appeal that other cryptocurrencies like Dogecoin possess, which affects its market cap [4] - The project's slow development pace and rigorous testing of upgrades can hinder its competitiveness in the fast-moving cryptocurrency market [5] - Cardano has a loyal community, but its co-founder Charles Hoskinson's communication style may not resonate with all investors, as it focuses on detailed discussions rather than sensational content [6] Group 2: Total Value Locked (TVL) Metrics - Total value locked (TVL) is a critical metric for assessing the usage of Cardano's decentralized finance (DeFi) applications [7] - Cardano's TVL has decreased significantly, from a peak of over $720 million in December 2024 to around $219 million currently, while competitors like Ethereum and Solana have seen growth in their ecosystems [9]

Economic & Social Commentary - The text critiques the dichotomy between corporatism and socialism, comparing it to a perilous choice [1] - Innovations in contract law, property law, and financial markets have historically benefited economies [2] - Over-reliance on large-scale, remote, trust-based institutions like governments and corporations is identified as a source of cultural problems [3] - The text advocates for reducing trust in strangers by shifting focus to smaller social scales [4] - It suggests prioritizing aspects of life beyond GDP and economic productivity, such as family, friends, and local communities [5] - The text calls for protecting long-standing religions and non-commercial traditions from disruptions caused by corporations and governments, including globalization and immigration [6] Institutional & Technological Impact - Trust-minimized institutions leveraging blockchains, smart contracts, and AI are expected to improve global economies [2] - The text emphasizes the need for innovations that substitute verification and security for trust in large social scales [4]

RT Nick Szabo (@NickSzabo4)Corporatism vs. socialism: an awful dichotomy, like Odysseus having to choose between having his ships destroyed by rocks if he steered them a bit too far north, and being sucked in by a whirlpool if they went a bit too far south.Innovations at large social scales -- and I daresay I helped a bit with that myself -- have often been a great economic boon for mankind. Innovations in contract law, property law, financial markets, and related areas have, after maturation, often turned ...

RT XXIM - Decentralise Capitalism (@xximpod)Strongly agree and must say brilliantly framed Scylla and Charybdis.Trust-minimized global tools like smart contracts let us reap large-scale benefits without surrendering our lives to remote bureaucracies or megacorps.Atleast for us the real path forward and a real test for humans is how we use them, either to to shield the small-scale institutions (family, church, durable local traditions) or to extend and propel the same remote bureaucracies or megacorps even f ...

Economic & Institutional Innovation - Innovations in contract law, property law, and financial markets have historically provided significant economic benefits after maturation [2] - Trust-minimized institutions at a global scale, leveraging blockchains, smart contracts, and AI, are expected to further improve global economies [2] Societal & Political Concerns - Over-emphasis on large scales in politics and economics, particularly remote trust-based institutions like governments and global corporations, has contributed to cultural issues [3] - The focus on GDP and economic productivity should be balanced with attention to smaller social scales, such as family, friends, and local communities [5] Community & Cultural Preservation - There is a need to reduce reliance on trust in strangers by refocusing political and cultural attention on smaller social scales [4] - Prioritization should be given to forming, growing, and protecting families and communities with long-standing shared understandings and traditions [6] - Long-standing religions and non-commercial traditions should be protected from disruptions caused by corporations, remote governments, and globalization [6]

RT Nick Szabo (@NickSzabo4)Corporatism vs. socialism: an awful dichotomy, like Odysseus having to choose between having his ships destroyed by rocks if he steered them a bit too far north, and being sucked in by a whirlpool if they went a bit too far south.Innovations at large social scales -- and I daresay I helped a bit with that myself -- have often been a great economic boon for mankind. Innovations in contract law, property law, financial markets, and related areas have, after maturation, often turned ...

“Private smart contracts are the last big missing piece of what our industry is supposed to supply to the financial system."@SergeyNazarov explains how Chainlink Confidential Compute and CRE enable institutions to create private smart contracts on any chain ↓Chainlink (@chainlink):"We're really devoting a huge amount of resources as a community to bringing the institutional world onchain."At SmartCon 2025, @SergeyNazarov joined the @ThinkingCrypto1 podcast to discuss the acceleration of institutional adopti ...