编辑丨王多鱼 排版丨水成文 在动物基因组中，被称为 增强子 （ enhancer ） 的调控性 DNA 元件控制着特定细胞类型中基因表达的精确时空模式。然而，增强子在细胞核内的空间组织以调 控靶基因的方式，目前仍知之甚少。 2025 年 7 月 2 日 ，北京大学生物医学前沿创新中心 （ BIOPIC ） /昌平实验室 谢晓亮 院士团队在 Nature Genetics 期刊发表了题为 ： Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs 的研究论文。 研究团队开发了 单细胞 Micro-C （scMicro-C） 技术，这种是基 于微球菌核酸酶 （ Micrococcal nuclease ） 的 3D 基因组图谱技术，能够以 高分辨率描绘 3D 基因组结构，并表征了 多增强子中心 （ multi-enhancer hub ） ，即多个增强子与基因启动子相关联，形成空间簇。 此外，该研究还观察到，在单细胞 3D 基因组结构中，具有 PES 的基因 ...

2025 年 7 月 6 日 总量研究 在 2025 年 1 月 9 日的报告《论 DR007 的属性及其取舍》中我们曾阐释 OMO 逆回购操作具有"工具模式"和"非工具模式"。在"非工具模式"下，货币当 局舍弃对于 OMO 规模的主动调节，OMO 规模不再是中央银行调节流动性的手 段，而是由各一级交易商根据政策利率、自身流动性的需求、对市场的判断决定。 市场竞争的作用使得最终形成的 DR007 中枢会略微高于 7D OMO 利率，此外实 践中 DR001 的中枢略低于 7D OMO 利率。例如，在 2024 年内，DR007 平均高 出 7D OMO 利率 10.4bp，DR001 平均低于 7D OMO 利率 4.5bp。（注：我们判 断 2024 年 OMO 基本处于"非工具模式"，故选取该段时间作为研究窗口。） 当前 DR007 和 DR001 与 7D OMO 之间的利差分别为 2.2bp 和-8.6bp，皆已明 显低于 2024 年的均值，更接近于该段时间的 1/4 分位数（注：2.8bp 和-10.7bp）。 我们判断，在下次 OMO 降息之前，DR007 和 DR001 中枢进一步下行的空间是 ...

The system of import permits and promotion of domestic industry that was introduced to India under its first prime minister holds important lessons for America. We explain how https://t.co/5WqGISEubA ...

With no homegrown tech giants and more onerous regulations, Europe has largely stayed out of the autonomous-driving race. Now, it’s hitting the accelerator. https://t.co/6P94rx5Qfu ...

Core Viewpoint - Alphabet is positioned as the best investment choice among the "Magnificent Seven" stocks, with significant potential upside in various sectors including search, AI infrastructure, autonomous driving, and quantum computing [1]. Group 1: Search and Advertising - Concerns about AI chatbots replacing traditional search are prevalent, but AI queries are more expensive to run compared to traditional searches, which supports Alphabet's ad-supported search model [3]. - Alphabet's dominance in search is reinforced by its ownership of distribution channels, including the Android operating system and Chrome browser, as well as revenue-sharing agreements with Apple and other browsers [3]. - The company has built one of the largest digital advertising platforms, with user-friendly self-serve ad tools that cater to businesses of all sizes [4]. Group 2: Monetization Opportunities - Currently, only about 20% of Alphabet's searches include ads, indicating substantial room for growth in monetization [5]. - New AI-powered features like "Shop by AI" and virtual try-ons are being introduced, enhancing user experience and creating additional monetization avenues [5]. - The integration of AI and traditional search is likely to be complementary, with many users expected to continue using free, ad-based search options [6]. Group 3: Cloud Computing - Google Cloud is experiencing significant growth, with a 28% increase in revenue and a 142% surge in operating income last quarter [7]. - The Vertex AI platform is attracting customers for building and managing AI models, while Alphabet's Gemini foundational model provides a competitive edge [8]. - Custom-built Tensor Processing Units (TPUs) are designed to optimize AI workloads, offering both power and energy efficiency compared to traditional GPUs [9]. Group 4: Future Technologies - Alphabet is entering the AI chip market with the launch of Ironwood, a TPU designed for inference, which is expected to grow significantly [11]. - Waymo, Alphabet's autonomous driving subsidiary, is expanding rapidly and has shown strong usage metrics, indicating a promising future despite current unprofitability [12]. - The company is also making strides in quantum computing with its Willow chip, which has demonstrated a significant reduction in error rates [13]. Group 5: Valuation - Alphabet is currently trading at a forward price-to-earnings (P/E) ratio of just over 18 times 2025 analyst estimates, suggesting it is undervalued compared to its market position [14]. - The company holds leading positions across multiple sectors, making it an attractive option for long-term investors seeking a technology leader at a reasonable price [15].

Watch out for Spot!Boston Dynamics’ agile mobile robot has been on patrol at Cargill’s oilseed facility since mid-2024, helping out with routine inspections and visual safety checks.It’s all part of Cargill’s push toward more autonomous operations, where robots handle the rounds, and humans focus on bigger-picture tasks like predictive maintenance and long-term planning. ...

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FUD is temporary and fakeFOMO is real and strongJust check how many and how muchall these big companies are buying forTheir treasuries every week. Bears willget slaughtered as soon as QE and ratecuts start in Q3-Q4Bitcoin is going to $200,000 in 2025 ...

Core Viewpoint - The investment landscape is shifting, with traditional high-performing growth stocks losing their leading positions, prompting a search for new growth opportunities in the market [2][3]. Group 1: Uber Technologies - Uber Technologies is experiencing significant growth due to a shift in personal mobility preferences, particularly among younger generations who are less interested in car ownership and driver's licenses [4][5]. - In the previous year, Uber's drivers completed nearly 11.3 billion trips, marking a 19% increase from the prior year, indicating sustained growth potential [6]. - The company's delivery segment is also expanding rapidly, with the online food delivery market expected to grow over 17% annually through 2034 [9]. - The future potential of Uber is further enhanced by the anticipated development of self-driving vehicles, which could halve operational costs, although widespread deployment may take 10 to 20 years [10]. Group 2: Rocket Lab - Rocket Lab is positioned as a viable alternative to larger launch companies like SpaceX, utilizing its Electron rocket for smaller satellite launches, having successfully launched 232 satellites to date [13]. - The company is developing a larger Neutron rocket capable of carrying up to 13,000 kilograms, which will enable deep-space missions, including potential trips to the moon and Mars [15]. - Analysts predict Rocket Lab will achieve profitability by 2027, with the global commercial space launch market expected to grow at nearly 15% annually through 2034 [16]. Group 3: Snap - Snap has seen its daily user base grow to a record 460 million, although growth is primarily outside North America and Europe, where user numbers are declining [18][19]. - The company's revenue increased by 20% in Q1, with North American revenue up 12% year-over-year, indicating strong financial performance despite user growth challenges [20]. - Snap is evolving its platform with new tools for content creators and subscription offerings, which are expected to enhance user engagement and profitability moving forward [22][23].

Core Viewpoint - Tesla's true value may lie in its future product platforms, such as autonomous robotaxis and humanoid robots, rather than its current electric vehicle (EV) sales [1][10] Sales Performance - Tesla delivered 1.79 million EVs in 2024, marking a 1% decline from the previous year, which is the first annual drop since 2011 [5] - In Q1 2025, Tesla delivered 336,681 EVs, reflecting a 13% year-over-year decline [6] - For Q2 2025, Tesla delivered 384,122 EVs, also down 13% year-over-year, indicating a potential sharper annual decline in sales for 2025 compared to 2024 [6] Competitive Landscape - Tesla's sales in Europe fell by 40% in May, while the overall EV market in Europe grew by 26% [7] - Chinese EV brands have doubled their market share in Europe, presenting significant competition for Tesla [7] - Tesla's pricing strategy is challenged by competitors like BYD, which offers lower-priced models, making it difficult for Tesla to compete in key markets [8] Future Product Development - Tesla is focusing on its Cybercab robotaxi, which will operate on full self-driving software, avoiding a price war with competitors [9][10] - The goal is to have millions of Cybercabs generating revenue through passenger transport and small deliveries [10] Financial Implications - Tesla's total revenue shrank by 9% in Q1 2025, with earnings plummeting by 71% to $0.12 per share [13] - The stock is down approximately 34% from its peak, but the decline in earnings is more severe, leading to a high price-to-earnings (P/E) ratio of 173.4 [14] - Comparatively, major tech companies have an average P/E ratio of 35.4, indicating Tesla's stock may be overvalued [15] Market Outlook - If Tesla's FSD and Cybercab initiatives succeed, the current stock price may appear cheap in the long term, but regulatory hurdles remain [16] - Significant declines in stock value could occur if EV sales continue to drop or if the robotaxi business fails to gain traction [18]