Core Insights - Roche expects mid single-digit growth in Group sales and high single-digit growth in core earnings per share for 2025, along with an increase in dividends [1][4]. Financial Performance - Group sales for the first half of 2025 reached CHF 30.9 billion, a 7% increase at constant exchange rates (CER) and a 4% increase in CHF compared to 2024 [2][5]. - The Pharmaceuticals Division reported sales of CHF 24.0 billion, reflecting a 10% increase at CER and a 6% increase in CHF [6][16]. - The Diagnostics Division's sales remained stable at CHF 7.0 billion, showing a 3% decline in CHF [12][31]. - Core operating profit increased by 11% (6% in CHF) to CHF 12.0 billion, driven by higher sales and effective cost management [5][6]. - Core earnings per share rose by 12% (8% in CHF), while IFRS net income increased by 23% (17% in CHF) to CHF 7.8 billion [6][31]. Key Growth Drivers - The top five growth drivers in the Pharmaceuticals Division included Phesgo, Xolair, Hemlibra, Vabysmo, and Ocrevus, which collectively generated CHF 10.6 billion in sales, an increase of CHF 1.7 billion at CER compared to the first half of 2024 [7][9]. - Sales in the United States grew by 10%, driven by the continued growth of Xolair and the uptake of Hemlibra, Ocrevus, Vabysmo, and Phesgo [9][10]. - The International region saw a 14% increase in sales, led by Phesgo, Hemlibra, and Vabysmo, with China reporting a 9% increase [12][13]. Regulatory Approvals and Pipeline Developments - Roche received several important regulatory approvals, including US approval for Susvimo for diabetic retinopathy and EU approval for Itovebi for advanced breast cancer [3][15]. - Four potentially practice-changing therapies advanced into the final phase of clinical development, including NXT007 for haemophilia A and prasinezumab for early-stage Parkinson's disease [3][4]. - The introduction of the Elecsys PRO-C3 test aims to improve precision in evaluating liver fibrosis severity [22][19]. Strategic Collaborations - Roche announced a collaboration with Broad Clinical Labs to accelerate the adoption of SBX sequencing technology, focusing on genetic disorders in critically ill newborns [20][18].

Core Insights - Seer, Inc. and Korea University are launching a population-level study to identify blood-based cancer biomarkers for young adults in their 20s and 30s using Seer's Proteograph ONE Assay and advanced mass spectrometry technology [1][2][4] Study Overview - The study will analyze 20,000 plasma samples, including 15,000 from cancer patients and 5,000 from healthy controls, sourced from leading cancer institutions in Korea [2] - Funded by the K-Health MIRAE initiative, the three-year study aims to enhance early cancer detection and improve patient outcomes [2] Technological Advancements - Seer's Proteograph ONE workflow significantly increases the scale and efficiency of proteomic analysis, enabling faster and more cost-effective studies [4][6] - The study utilizes the Thermo Scientific Orbitrap Astral mass spectrometer, which is recognized as a leading instrument for proteomic research [4][5] Research Impact - The collaboration aims to drive earlier interventions and improve survival outcomes for young adult cancer patients through sensitive and personalized diagnostics [3][6] - The Proteograph ONE workflow allows for processing over 1,000 samples per week, with the ability to identify up to 10 times more proteins than conventional methods [5]