McKesson FY Conference Summary Company Overview - **Company**: McKesson Corporation (NYSE: MCK) - **Date of Conference**: December 04, 2025 - **Key Speakers**: Britt Vitalone (EVP and CFO), Elizabeth Anderson (Healthcare Services Analyst at Evercore) Key Points Financial Performance - **Revenue Growth**: 10% revenue growth in the second quarter [2] - **Operating Profit Growth**: Adjusted operating profit growth of 26% [2] - **Earnings Per Share Growth**: Adjusted earnings per share growth of 39% [2] - **Guidance Update**: Raised full-year guidance based on strong performance and cash flow [2] GLP-1 Drugs - **Market Position**: Continued strong growth in GLP-1s, with McKesson providing core distribution and Rx Technology Solutions for affordability and access [5][6] - **Future Outlook**: Positioned well for growth as GLP-1s potentially move to oral solid forms in 2026 [6] Oncology and Multi-Specialty Segment - **Acquisition Contributions**: Increased fiscal 26 AOI contribution guidance from Prism and Florida Cancer Center to $280-$320 million from $220-$270 million [7] - **Oncology Market Opportunity**: Estimated market opportunity of $115 billion, with $80 billion for distribution and GPO services [17] - **Clinical Trials Growth**: 25% year-over-year growth in clinical trial accrual rates [17] Operational Strategy - **Platform Development**: Focus on building platforms in areas with drug investment and innovation, including oncology and vision care [10][11] - **Automation and AI**: Significant investments in automation and AI to modernize operations, with 90% automation in new distribution centers [30][31] Medical Business Separation - **Separation Timeline**: Targeting a tax-free separation and potential IPO in the second half of fiscal 2027 [32][33] - **Focus on Independence**: Separation aimed at allowing the medical business to pursue its own strategies and capital structure [32] 3PL and Distribution Services - **3PL Growth**: Opportunities in established pharma, emerging biopharma, and cell and gene therapy sectors [46][47] - **Cash Pay Prescriptions**: Current cash pay for GLP-1s is small but could grow, presenting potential opportunities for McKesson [48][49] Generic Drugs and Pricing Strategy - **Generics Importance**: Generics remain a crucial part of McKesson's business, with a focus on high service levels and low costs [37][38] - **Pricing Model**: Shifted focus from composite pricing to managing individual generic products for better economic value [40][41] Market Environment and Policy - **Policy Volatility**: Successfully navigating various policy environments, with ongoing discussions with manufacturers regarding service fees [23][24] - **CMMI Demonstration Programs**: Early days for new programs, with McKesson well-positioned regardless of outcomes [26][27] Cash Flow and Investment - **Cash Flow Consistency**: High cash flow conversion historically, expected to continue [55] - **Investment in Rx Technology Solutions**: Increased investment anticipated in the second half of the fiscal year [68] Seasonality and Variability - **Quarterly Variability**: Acknowledgment of potential variations in performance due to seasonality and tax rate changes [64][68] - **Illness Season Impact**: Weaker illness season affecting medical business and some pull-through impacts on pharma business [70][71] Additional Insights - **Strategic Partnerships**: Emphasis on long-term partnerships and shared strategic vision among leadership [62][63] - **Customer-Centric Solutions**: Focus on enhancing customer and provider-centric solutions through technology and service extensions [57][58]