Financial Data and Key Metrics Changes - Total revenue for Q1 2025 was $155 million, with $138 million excluding license and royalty revenue, down 2% year over year [8][22] - Total consumables revenue was $115.4 million, up 5%, while instrument revenue was $14.8 million, down 42% [22][24] - Gross profit for Q1 was $105.4 million, with gross margins increasing to 68% from 66% year over year [25] - Operating loss for Q1 was $39.3 million, compared to a loss of $61.5 million in the same period last year [27] Business Line Data and Key Metrics Changes - Chromium consumables revenue was approximately flat at $84.1 million, while spatial consumables revenue increased by 18% to $31.2 million, driven by Xenium consumables [22][23] - Instrument revenue saw a significant decline, with Chromium instrument revenue down 25% and spatial instrument revenue down 49% [24][25] Market Data and Key Metrics Changes - Revenue in the Americas decreased by 7% to $73.8 million, EMEA decreased by 8% to $31.9 million, while APAC increased by 22% to $32.4 million [25] - Instrument revenue declined across all geographies, although strong consumable sales helped offset the impact in APAC [25] Company Strategy and Development Direction - The company is navigating a challenging macro environment, withdrawing full-year revenue guidance and implementing quarterly guidance due to uncertainty in U.S. academic and government research funding [12][29] - A reduction in workforce by approximately 8% has been implemented to enhance efficiency and protect the balance sheet [14][32] - The company is focused on product innovation and has seen increased usage of its products, particularly in single-cell and spatial biology [13][15] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate current challenges and emphasized the importance of maintaining a strong balance sheet [12][14] - The macro environment has created uncertainty, leading to unpredictable customer purchasing behavior and reduced visibility on the outlook for the year [11][29] - Management remains optimistic about long-term growth potential despite current turbulence, citing strong fundamentals and customer engagement [21][39] Other Important Information - The company has completed a sales reorganization to better address current challenges and has a strong cash position of $427 million at the end of Q1 [14][27] - Recent product launches have resonated well with customers, contributing to the company's technology leadership [13][17] Q&A Session Summary Question: Can you provide insights on recent customer conversations and the impact of NIH funding? - Management noted that conversations with customers have become increasingly dire due to uncertainty around funding, prompting cost-cutting measures among institutions [44][45] Question: How do you expect the year to play out regarding instrumentation versus consumables? - Management indicated that Q2 is expected to mirror Q1 trends, with pressure on CapEx in instrumentation but stable consumables performance [54][55] Question: What are the implications of the headcount reduction on future growth? - Management stated that the headcount reduction was carefully considered, with minimal impact on direct sales roles, and emphasized the importance of retaining talent for future growth [66][67] Question: How is the company addressing potential tariffs and demand in China? - Management confirmed that there has been no pull forward in demand due to tariffs, and they are actively working on mitigation strategies to maintain production capabilities [100]

Financial Data and Key Metrics Changes - Total revenue for Q1 2025 was $155 million, with $138 million excluding license and royalty revenue, down 2% year over year [5][20] - Total consumables revenue was $115.4 million, up 5%, while instrument revenue was $14.8 million, down 42% [20][21] - Gross profit for Q1 was $105.4 million, with gross margins increasing to 68% from 66% year over year [22] Business Line Data and Key Metrics Changes - Chromium consumables revenue was approximately flat at $84.1 million, while spatial consumables revenue increased by 18% to $31.2 million, driven by Xenium consumables [20][21] - Total instrument revenue saw a significant decline, with Chromium instrument revenue down 25% and spatial instrument revenue down 49% [21] Market Data and Key Metrics Changes - Revenue in the Americas decreased by 7% to $73.8 million, EMEA decreased by 8% to $31.9 million, while APAC increased by 22% to $32.4 million [22] - Instrument revenue declined across all geographies, although strong consumable sales helped offset the impact in APAC [22] Company Strategy and Development Direction - The company is navigating a challenging macro environment, withdrawing full-year revenue guidance and implementing quarterly guidance due to uncertainty in U.S. academic and government research funding [10][25] - A focus on cost-saving measures, including an 8% reduction in workforce, is aimed at maintaining a strong balance sheet while continuing to invest in key priorities [12][29] - The company is committed to long-term growth, with confidence in capturing large opportunities despite current challenges [19][30] Management's Comments on Operating Environment and Future Outlook - Management highlighted a deteriorating research funding environment, with significant impacts on customer purchasing behavior and project initiation [9][10] - There is optimism regarding the long-term potential of the company's products, particularly in single-cell and spatial biology, despite current market challenges [11][19] - The company is closely monitoring the evolving tariff landscape, with minimal reliance on China in its supply chain [27][28] Other Important Information - The company has completed a sales reorganization to enhance focus and coverage in the current environment [11] - Recent product launches have been well-received, contributing to increased usage and adoption among customers [14][15] Q&A Session Summary Question: Current backdrop and customer conversations - Management noted that customer conversations have become increasingly dire due to funding uncertainties, prompting cost-cutting measures among institutions [42][44] Question: Year outlook and instrumentation vs consumables - Management indicated that Q2 is expected to mirror Q1 trends, with pressure on CapEx in instrumentation but stable consumables performance [55][56] Question: Headcount reduction and OpEx initiatives - The company emphasized that the headcount reduction will lead to over $50 million in operating expense savings for 2025, while still retaining critical talent for growth [70][69] Question: Regional sales dynamics - Management acknowledged that while EMEA sales have declined, the fundamental business remains strong, and recent hiring in Europe is expected to improve performance [76][75] Question: Demand in APAC and potential pull forward - Strong underlying demand in APAC, particularly in China and Japan, was noted, with structural improvements contributing to robust performance [78][79] Question: Long-term growth opportunities in organoid research - Management expressed optimism about the potential for single-cell sequencing in organoid research, viewing it as a promising growth area [99][98] Question: Tariffs and demand in China - The company does not anticipate significant pull forward in demand due to tariffs, and it has strategies in place to mitigate potential impacts [108][107]