Financial Data and Key Metrics Changes - In Q3 2025, Ginkgo reported a cash position of $462 million with no bank debt, reflecting a significant reduction in quarterly cash burn by 75% from $114 million in Q3 2024 to $28 million in Q3 2025 [4][11] - Total adjusted EBITDA for Q3 2025 was negative $56 million, down from negative $20 million in Q3 2024, primarily due to a $21 million shortfall related to a Google Cloud contract and a $45 million non-cash revenue from a prior customer agreement [10][12] Business Line Data and Key Metrics Changes - Cell engineering revenue was $29 million in Q3 2025, a 61% decrease compared to Q3 2024, with a 5% decrease in revenue-generating programs attributed to ongoing program rationalization [6][8] - Biosecurity revenue generated $9 million in Q3 2025, with a segment gross margin of 19% [7] Market Data and Key Metrics Changes - The company reaffirmed its overall revenue guidance for 2025, projecting total revenue between $167 million and $187 million, with cell engineering revenue expected to be between $117 million and $137 million, and biosecurity revenue expected to be at least $40 million [12] Company Strategy and Development Direction - Ginkgo aims to deliver robotics and software for autonomous labs at customer sites, expand its frontier autonomous lab in Boston, and provide best-in-class CRO services leveraging in-house robotic infrastructure [2][3] - The company is focusing on AI's impact on biotechnology, particularly through reasoning models and automation, to enhance laboratory efficiency and reduce costs [13][20] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in navigating the macro environment while continuing to execute core objectives, emphasizing the importance of investing in automation and AI tooling for future growth [12][40] - The management highlighted the need for the U.S. to invest in robotic infrastructure to compete with China's growing biotech sector [19][20] Other Important Information - Ginkgo has made significant strides in reducing costs while maintaining a strong cash position, allowing for future investments in growth [4][40] - The company is actively building a community around AI models trained on biological data through initiatives like the Antibody Developability Competition [24][26] Q&A Session Summary Question: Impact of U.S. government shutdown on Ginkgo's business - Management indicated that the shutdown has not significantly impacted the company, as grants and funding continue to flow [41] Question: Development and rollout path for the rack system - Management expressed excitement about the scalability and productization of the rack system, aiming for broader adoption in the next 18 months [42][44] Question: Ideal revenue mix by 2030 - The company envisions an 80-20 revenue mix favoring tools over services by 2030, with a focus on becoming a dominant provider of general-purpose R&D infrastructure [50][51] Question: Details on the Google Cloud contract reset - Management provided insights on favorable terms negotiated with Google, reducing future commitments and extending the contract period [52][53] Question: AI's role in R&D landscape - Management discussed the potential of AI and robotics to transform drug discovery and laboratory operations, enabling researchers to pursue multiple hypotheses simultaneously [56][58]

Financial Performance & Targets - Ginkgo achieved $205 million in annual run-rate cost savings from Q1 2024 to Q1 2025[13] - The company maintains a strong financial position with $517 million in cash, cash equivalents, and marketable securities[15] - Total Adjusted EBITDA improved from $(117) million in Q1 2024 to $(47) million in Q1 2025, a 59% increase[34] - Ginkgo is targeting Adjusted EBITDA breakeven by the end of 2026[11, 49] - The company aims for $250 million of annualized run-rate savings target by the end of Q3 2025[53] Revenue & Growth - Cell Engineering revenue increased by 37% year-over-year, reaching $38 million in Q1 2025[34] - This includes recognition of $75 million non-cash deferred revenue from BiomEdit[24] - Total revenue increased by 27% year-over-year, from $38 million to $48 million[34] - Biosecurity revenue remained stable at $10 million in Q1 2025 compared to Q1 2024[34] Biosecurity Expansion - Ginkgo's biosecurity segment has expanded its reach to 127 countries of origin of flights sampled, representing 65% of nations globally[33] - The biosecurity network includes 11 key international airports and 45 collection nodes cumulatively in 2025[33]