ConversationD. WalkeSenior Vice President of Investor Relations Good morning, and welcome, everyone, to Ionis Pharmaceuticals 2025 Innovation Day. I'm Wade Walke, Head of Investor Relations. And it's great to see so many of you here in the room with us today. We'd also like to welcome those who are joining us today online via our webcast. Every 2 years, we host this meeting in order to give you an update on the progress we're making on our goal to transform the lives of people with unmet -- severe unmet me ...