Core Viewpoint - Brainstorm Cell Therapeutics has secured a strategic private placement of $1 million, reflecting confidence in its operational momentum and the value of its NurOwn® platform [1] Financing Details - The financing is structured in two tranches, with the first payment of $500,000 already received and the second payment of $500,000 expected within 30 days [1] - The common stock was priced at $0.60 per share, a significant premium to the $0.54 closing price on February 9, 2026 [1] - The investment includes 120% warrant coverage for five years with an exercise price of $1.00 per share, indicating a nearly 100% premium to the recent market close [1] Company Strategy and Future Plans - The financing follows a period of strategic activity, including finalizing the Phase 3b trial design under a Special Protocol Assessment (SPA) and discussions regarding a Citizens Petition for Accelerated Approval [1] - Proceeds from the financing will support ongoing regulatory initiatives, prepayments for the upcoming Phase 3b trial of NurOwn® in ALS, and general corporate purposes [1] About NurOwn® Technology - NurOwn® technology involves autologous MSC-NTF cells, which are designed to deliver neurotrophic factors and immunomodulatory cytokines to target neurodegenerative diseases [1] - The platform has received Orphan Drug designation from both the FDA and the EMA, with a Phase 3 trial in ALS completed and a second Phase 3b trial set to launch [1] Company Background - Brainstorm Cell Therapeutics is focused on developing autologous adult stem cell therapies for neurodegenerative diseases, with a proprietary platform aimed at modulating neuroinflammation and promoting neuroprotection [1]

Core Insights - BrainStorm Cell Therapeutics Inc. reported financial results for Q2 2025 and provided updates on its clinical development plan for NurOwn, a therapy for neurodegenerative diseases, particularly ALS [1][2] Clinical Development - The FDA has granted clearance for BrainStorm to initiate a Phase 3b clinical trial of NurOwn, named ENDURANCE, which aims to enroll approximately 200 participants at leading academic medical centers [4] - The trial will consist of a 24-week randomized, double-blind, placebo-controlled phase followed by a 24-week open-label extension, with the primary endpoint being the change in the ALS Functional Rating Scale-Revised (ALSFRS-R) from baseline to week 24 [4] - A Citizen Petition has been submitted to the FDA by the ALS community for a new review of NurOwn data, which the company supports as an opportunity to reaffirm the therapy's potential [4] Financial Performance - As of June 30, 2025, BrainStorm reported cash, cash equivalents, and restricted cash of approximately $1.03 million [4] - Research and development expenditures for Q2 2025 were $1.1 million, an increase from $0.9 million in Q2 2024 [4] - General and administrative expenses decreased to approximately $1.4 million in Q2 2025 from approximately $2.1 million in Q2 2024 [4] Survival Data - New survival data from the NurOwn Expanded Access Program indicated that 100% of participants (10 out of 10) survived more than 5 years from the onset of ALS symptoms, compared to an estimated 10% survival rate for ALS patients [4] - The median survival observed in the EAP cohort was 6.8 years from symptom onset, with a range of 6 to 7 years [4] Manufacturing and Partnerships - BrainStorm has signed a Letter of Intent with Minaris Advanced Therapies for the manufacturing of NurOwn for the upcoming Phase 3b clinical trial [4] - The NurOwn data was selected for presentation at the ISCT 2025 Meeting, highlighting the impact of the UNC13A genotype on clinical outcomes for ALS patients treated with NurOwn [4] Company Overview - BrainStorm Cell Therapeutics Inc. specializes in developing autologous adult stem cell therapies for neurodegenerative diseases, with its proprietary NurOwn platform utilizing mesenchymal stem cells to produce neurotrophic factor-secreting cells [6][7]