Vericel FY Conference Summary Company Overview - **Company**: Vericel (NasdaqGM:VCEL) - **Industry**: Advanced therapies for sports medicine and severe burn care - **Core Products**: - **MACI**: A cell therapy for cartilage repair, launched in 2017, leading in its category with a 24% compounded annual growth rate since launch - **NexoBrid**: An enzymatic debridement agent for burn treatment - **Epicel**: A graft product using a patient's own cells for burn wound coverage - **Market Position**: Unique combination of high revenue and profit growth, strong cash generation, and a competitive moat with no direct product competition [6][9][12] Financial Performance - **2025 Performance**: - MACI growth: 20%+ in Q4, 23% overall for the quarter - Burn care growth: 25% in Q4 - Gross margin: 79% in Q4, EBITDA at 40% - **Long-term Targets**: Expecting gross margins in the high 70% range and EBITDA to increase despite investments in growth [12][19][20] Product Insights - **MACI**: - Strong adoption due to less invasive procedures and superior clinical outcomes compared to predecessors - Surgeons trained on MACI Arthro showed higher biopsy and implant growth rates - Anticipated continued growth driven by increased surgeon training and market penetration [11][32][33][37] - **NexoBrid and Epicel**: - NexoBrid is gaining traction as a non-surgical option for burn treatment, with potential government support for stockpiling in mass casualty events - Epicel's growth is more variable due to the small patient base and unpredictability of severe burn cases [66][68][75] Manufacturing and Operational Updates - **New Manufacturing Facility**: Recently FDA approved, expected to enhance production capabilities and efficiency - **Transition Risks**: Mitigated through careful planning and operational execution, with a phased approach to moving production from the old facility [22][25][26] Market Opportunities - **Expansion Plans**: - MACI's potential expansion into ankle cartilage repair, targeting a billion-dollar market - Continued focus on training surgeons and expanding product use in other joints [58][64] - **Burn Care Market**: - Addressing the unpredictability of severe burn cases while leveraging government interest in NexoBrid for military applications [68][75] Conclusion - **Outlook**: Vericel is positioned for continued growth with strong product performance, a solid financial foundation, and strategic expansion plans in both sports medicine and burn care markets. The company is optimistic about achieving its growth targets for 2026 and beyond, particularly with the MACI franchise and new manufacturing capabilities [19][28][37][75]

Company Overview - Vericel is a leader in advanced cell therapies for the sports medicine and severe burn care markets[6, 11, 18, 22, 99] - The company utilizes an innovative advanced therapy platform, combining devices and biologics that use a patient's own cells to repair tissue and restore function[10] Financial Performance & Market Opportunity - The company achieved 45% trailing twelve-month product revenue growth[12] - Total trailing twelve-month product revenues reached $90.9 million as of December 31, 2018[13] - Vericel is operating in addressable markets valued at over $2 billion[14] - The company has cash and short-term investments of approximately $83 million with no debt as of December 31, 2018[22, 98] MACI Product Highlights - Cartilage defects are found in approximately 60% of knee arthroscopies[33, 34] - MACI demonstrated statistically significantly greater improvement in KOOS pain and function scores compared to microfracture at year 2 (p = 0.001)[52, 53] - 87.50% of patients responded to MACI treatment compared to 68.10% with microfracture (p = 0.016)[55, 56] Epicel Product Highlights - Epicel is a permanent skin replacement for full-thickness burns covering 30% or more of the total body surface area[76] - Data demonstrates a lower mortality rate for Epicel patients compared to the National Burn Repository[82] - The addressable market for Epicel in the U S is estimated at $120 million[86]