CDN

Search documents
细胞新图谱揭示关键DNA对癌症进化的作用
Huan Qiu Wang Zi Xun· 2025-06-19 02:47
此次研究结合了空间转录组学(对DNA活性进行测量与图谱绘制)和基因组数据,成功识别出源自同 一祖先但获得额外突变的不同细胞群落。这些细胞的空间分布图,有助于揭示肿瘤的演化路径。这一系 列新发现为精准医疗研究提供了坚实的数据支撑,推动了创新技术应用,从而实现更优疗效、更低副作 用的治疗目标。 团队通过对少量胶质瘤样本(发生在大脑或脊髓中的肿瘤)进行批量RNA测序、肿瘤/正常DNA测序及 空间转录组学分析,识别出肿瘤微环境中的共性特征与独特模式,构建出了这个可供其他科研团队参考 的整合分析框架。 现阶段研究主要聚焦于几种类型的脑癌,但所展示的空间转录组学方法和基因组测序技术,有朝一日将 广泛应用于各类癌症的个体化治疗中。 团队表示,癌症及其治疗从来不是"一刀切"的问题。理解ecDNA在可遗传与非遗传细胞附近的分子行 为,有助于揭示潜在的治疗靶点,并可评估癌症复发的风险。 来源:科技日报 科技日报讯 (记者张梦然)美国希望之城国家医疗中心在最新一期《自然·通讯》上发表文章称,他 们"绘制"了一种创新细胞图谱,首次揭示了癌症进化中一个极其关键角色——"染色体外 DNA"(ecDNA),其可预测突变的致癌基因如何重塑D ...
Cloudflare vs. Akamai Technologies: Which CDN Stock Has an Edge?
ZACKS· 2025-06-12 16:46
Key Takeaways Cloudflare projects 2025 revenues of $2.09B, up 25.4% year over year, driven by its CDN platform growth. Akamai's delivery revenues have declined for 17 straight quarters, raising concerns about its CDN business. NET shares are up 66.9% YTD, while AKAM has dropped 18.3%, reflecting diverging investor sentiment.Cloudflare (NET) and Akamai Technologies (AKAM) are both established players in the content delivery network (CDN) market. Both Cloudflare and Akamai are expected to gain from the rapi ...
Boundless Bio, Inc.(BOLD) - 2025 FY - Earnings Call Transcript
2025-06-09 14:20
Boundless Bio (BOLD) FY 2025 Conference June 09, 2025 09:20 AM ET Speaker0 Alright. Welcome, everyone. We for for the next session, we have, Zach Hornby from Boundless Bio joining us. Zach, welcome. It's the time for me to host you at at the Goldman Sachs conference. Maybe I'll just turn it to you for opening remarks before we kick it off with questions. Speaker1 Sure. Good morning, Rich, and thank you for hosting. Nice to be here in Miami on a Monday morning. So, yeah, Speaker0 I'm Speaker1 CEO of Boundles ...
Boundless Bio to Participate in the Goldman Sachs 46th Annual Global Healthcare Conference
Globenewswire· 2025-06-05 20:58
SAN DIEGO, June 05, 2025 (GLOBE NEWSWIRE) -- Boundless Bio (Nasdaq: BOLD), a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, today announced that Zachary Hornby, President and Chief Executive Officer, will participate in a fireside chat at the Goldman Sachs 46th Annual Global Healthcare Conference. The fireside chat session is scheduled for Monday, June 9, in Miami, FL, ...
Boundless Bio Announces Portfolio Prioritization and Runway Extension
Globenewswire· 2025-05-23 20:01
Portfolio prioritization focuses on novel-novel combination therapy of BBI-355 and BBI-825 and new development candidate, BBI-940, for novel kinesin program Operating runway extended into the first half of 2028, through expected proof-of-concept clinical readouts for each program Conference call and webcast to be held Tuesday, May 27 at 8:00 am ET SAN DIEGO, May 23, 2025 (GLOBE NEWSWIRE) -- Boundless Bio (Nasdaq: BOLD), a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to ...
盘前必读丨事关城市更新,中办、国办重磅部署;阿里巴巴第四财季营收同比增7%
Di Yi Cai Jing· 2025-05-15 23:49
当地时间周四,美股三大指数涨跌不一。道指涨0.65%,报42322.75点;标普500指数涨0.41%,报 5916.93点;纳指跌0.18%,报19112.32点。 机构认为,近期固态电池板块催化密集,继续推荐固态电池产业链。 | 名称 | 现价 | 涨跌 | 涨跌幅 | | --- | --- | --- | --- | | 道琼斯工业指数 | 42322.75 | 271.69 | 0.65% | | 纳斯达克指数 | 19112.32 с | -34.49 | -0.18% | | 标普500 | 5916.93 | 24.35 | 0.41% | 科技股普跌,微软涨0.23%,英伟达跌0.38%,苹果跌0.41%,亚马逊跌2.42%,Meta跌2.35%,特斯拉跌 1.4%。 热门中概股多数走低,阿里巴巴跌7.53%,京东跌3.86%,百度跌3.58%,蔚来跌3.15%,小鹏汽车跌 1.39%,拼多多跌0.88%,理想汽车跌0.59%,网易涨14.61%。 ►►据新闻联播,李强在做强国内大循环工作推进会上强调,把做强国内大循环作为推动经济行稳致远 的战略之举。 ►►商务部召开例行新闻发布会: -有记 ...
Boundless Bio Reports First Quarter 2025 Financial Results and Business Highlights
Globenewswire· 2025-05-09 11:00
Initial proof-of-concept data from the ongoing BBI-355 Phase 1/2 POTENTIATE trial in patients with oncogene-amplified cancers anticipated in the second half of 2025 Novel Kinesin program on track for mid-2025 development candidate nomination and IND filing in the first half of 2026 $138 million cash position provides operating runway into 2027 SAN DIEGO, May 09, 2025 (GLOBE NEWSWIRE) -- Boundless Bio (Nasdaq: BOLD), a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to del ...
网宿科技:2024年度拟分配现金红利占净利润比例为90.59%
Quan Jing Wang· 2025-04-29 10:11
更多业绩说明会详情,请点击:https://rs.p5w.net/html/145874.shtml 此外,公司也积极用现金股利回馈股东,2024年度分红预案为:以公司现有总股本(扣除回购专户的股 份数)为基数,向全体股东每10股派发现金红利2.5元(含税),合计派发现金红利6.11亿元,2024年度 公司拟分配现金红利占公司2024年度净利润的90.59%。另外,公司也会主动地与投资者保持沟通,就 公司情况与投资者进行交流。 4月29日,网宿科技(300017)2024年度网上业绩说明会在全景路演举行。有投资者提问:公司有考虑 股价管理么? 网宿科技董事长、总经理Hong Ke (洪珂)回复:公司业绩是投资者信心的基石,2024年,公司实现营 业收入49.32亿元,同比增长4.81%;净利润6.75亿元,同比增长10.02%。2025年第一季度,公司实现营 业收入12.35亿元,同比增长10.26%;净利润1.92亿元,同比增长38.54%。 公开资料显示,网宿科技致力于成为全球领先的IT基础平台服务提供商。凭借公司在计算、存储、网络 及安全等方面的核心技术及服务能力,为互联网客户、政府及企业客户提供高效、 ...
Cell:中科院深圳先进院甘海云团队揭示ecDNA维持的关键机制
生物世界· 2025-04-28 08:44
编辑丨王多鱼 排版丨水成文 染色体外 DNA (extrachromosomal DNA,ecDNA) 是一种独立于染色体存在的环状 DNA 分子,在 30%-50% 的恶性肿瘤患者中被检测到。尽管早在 1965 年研究人员就在神经母细胞瘤中观察到其存在 (当 时称为双微体) ,但受限于技术手段,其存在的生物学意义长期未被阐明。 近年来的研究发现,ecDNA 可携带完整的致癌基因 (例如 MYC、EGFR) 及其增强子序列。当这些基因从 染色体脱落并环化形成 ecDNA 后,原本的表观遗传修饰 (例如 DNA 甲基化和组蛋白修饰) 记忆丢失,导 致癌基因的异常激活。 临床证据表明,携带 ecDNA 的肿瘤患者往往表现出更高的恶性程度、更强的治疗抵抗和更差的临床预后。 因此,靶向 ecDNA 的抗肿瘤策略 (例如干扰其复制与维持、调控表观遗传重塑) 具有重要治疗潜力。然 而,ecDNA 的复制与维持机制、表观遗传重塑及其在肿瘤发生发展中的精确作用,仍是当前研究的核心挑 战。解决这些问题将为开发新型抗癌疗法提供关键突破口。 2025 年 4 月 28 日,中国科学院深圳先进技术研究院定量合成生物学全国重点实验室、 ...
Boundless Bio to Participate in the Leerink Global Healthcare Conference
Globenewswire· 2025-02-26 12:00
Company Overview - Boundless Bio is a clinical-stage oncology company focused on developing therapies for patients with oncogene amplified cancers by targeting extrachromosomal DNA (ecDNA), which is implicated in 14 to 17% of cancer cases [3]. - The company is developing its first ecDNA-directed therapeutic candidate, BBI-355, an oral inhibitor of checkpoint kinase 1 (CHK1), currently in a Phase 1/2 clinical trial [3]. - Boundless Bio utilizes its Spyglass platform for additional programs that are in preclinical development and discovery [3]. Upcoming Events - Zachary Hornby, President and CEO of Boundless Bio, will participate in a fireside chat at Leerink's Global Healthcare Conference on March 12, 2025, at 11:20 a.m. ET in Miami, FL [2]. - A live and archived webcast of the session will be available on Boundless Bio's website under the "Events & Presentations" section [2].