Financial Data and Key Metrics Changes - The company reported revenue of $213 million for Q2 2025, representing a 5% year-over-year increase, excluding the impact of UnitedHealthcare's decision on GeneSight and the divested European ENDOPREDICT business [7][34] - Adjusted gross margins improved to 71.5%, an increase of 140 basis points compared to the previous year [12][38] - Adjusted EBITDA for the quarter was $14.5 million, reflecting a 24% growth year-over-year [12][45] Business Line Data and Key Metrics Changes - Hereditary cancer revenue grew by 5% for the quarter, with a 10% volume growth in the oncology channel [23] - GeneSight volume increased by 5% year-over-year, recovering from low single digits [10][31] - Prenatal products, PREQUEL and FORESIGHT, saw a 7% decline in volume year-over-year due to challenges with an order management system, which has since been resolved [11][29] Market Data and Key Metrics Changes - The oncology market showed strong growth, with hereditary cancer testing volume increasing by 14% year-over-year [9][25] - The prenatal health market is expected to grow at or above market rates, driven by new product launches and expanded payer coverage [19][30] - Mental health testing through GeneSight generated revenues of $38 million, with a 5% volume growth year-over-year [31] Company Strategy and Development Direction - The company is focusing on the cancer care continuum (CCC) as a strategic priority to drive accelerated growth and profitability [14][15] - Three strategic pillars include enhancing hereditary cancer testing, growing prenatal and mental health revenues, and maintaining financial discipline [18][20] - The company plans to increase investments in R&D and enhance commercial capabilities to support the CCC strategy [17][21] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the company's potential and the progress made in addressing previous challenges [6][8] - The company raised its guidance for 2025 based on positive Q2 results and ongoing improvements in execution [13][45] - Management emphasized the importance of strategic partnerships and operational excellence to drive future growth [17][22] Other Important Information - The company secured a $200 million term loan from OrbiMed, providing liquidity and flexibility for growth initiatives [13][43] - A significant non-cash impairment charge of $317 million was recognized due to a decline in market capitalization, but this does not reflect a change in business outlook [39][40] Q&A Session Summary Question: Request for more specific KPIs related to the strategic review - Management acknowledged the need for more quantifiable KPIs and plans to share these in the upcoming months [52][56] Question: Clarification on portfolio divestitures - Management indicated satisfaction with the current portfolio and stated that periodic reviews will be conducted to assess strategic alignment [53][56] Question: Impact of UnitedHealthcare's coverage on GeneSight - Management confirmed ongoing discussions with UnitedHealthcare and plans to submit new clinical data for review in the fall [60][64] Question: Clarification on the timing of the MRD test launch - Management confirmed an early access launch for the MRD test in the first half of 2026, with ongoing clinical studies [66][68] Question: Guidance for the back half of the year - Management indicated that the guidance raise is based on improved execution and recovery from previous challenges, particularly in hereditary cancer testing [88][90]

Core Insights - Myriad Genetics reported solid second-quarter results, driven by strong hereditary cancer testing in oncology and favorable pricing trends, while also updating its financial guidance for the full year 2025 [2][3] Financial Performance - Second quarter 2025 revenue was $213.1 million, a 1% increase year-over-year, with a 5% increase when excluding headwinds of $9.5 million [5] - Hereditary cancer testing revenue and volume in oncology grew by 9% and 10% year-over-year, respectively, with MyRisk with RiskScore testing volume in oncology increasing by 14% [5][17] - Gross margin for the second quarter 2025 was 71.2%, up over 160 basis points year-over-year, benefiting from product mix and improved laboratory efficiencies [5] - The company reported a GAAP net loss of $330.5 million, or $(3.57) per share, primarily due to non-cash impairment charges of $316.7 million [5][11] - Adjusted EPS for the second quarter 2025 was $0.05 [5] Strategic Update - Myriad Genetics is focusing on the Cancer Care Continuum (CCC) to accelerate growth, with plans to expand its test portfolio into therapy selection and immuno-oncology therapy response monitoring [6] - The company aims to grow revenue in Prenatal Health and Mental Health while maintaining disciplined investment in these areas [7] - Myriad Genetics expects to achieve high single-digit to low double-digit revenue growth and increased profitability over the next five years [7] Business Unit Performance - The Oncology business generated revenue of $85.5 million in the second quarter of 2025 [13] - The Women's Health business reported revenue of $89.8 million in the same period [14] - GeneSight test revenue was $37.8 million, with a 5% year-over-year growth in test volume, despite the impact of UnitedHealthcare's decision to discontinue coverage [15] Financial Guidance - The company raised its 2025 revenue guidance to a range of $818 - $828 million, up from $807 - $823 million, reflecting improved business outlook [19] - Adjusted operating expenses for 2025 are projected to be between $562 - $568 million [19] - Adjusted EBITDA guidance was increased to a range of $27 - $33 million [19]