Cervical Cancer Burden and Global Impact - Cervical cancer is the fourth leading cause of cancer and cancer deaths in women worldwide, with 660,000 cases and 350,000 deaths annually [4] - Over the past 50 years, vaccines have saved 154 million (154,000,000) lives globally, equating to 6 lives every minute [8] - Vaccines have contributed to a 40% decline in child mortality and have gifted 102 billion (10,200,000,000) years of healthy life [9][10] - In Nepal, cervical cancer is the number one cause of cancer deaths in women [16] HPV Vaccine and Prevention Strategies - HPV (Human Papilloma Virus) infection causes more than 90% of cervical cancer cases [4] - HPV vaccine is most effective when administered to girls between 9 and 14 years of age, before the start of sexual activity, with a single shot providing 95-98% protection [6] - WHO recommends a 90-70-90 strategy: 90% of girls under 15 vaccinated, 70% of women screened by 35 and again by 45, and 90% of those with cervical cancer treated [18][19] Nepal's Immunization Program and HPV Vaccine Rollout - Nepal's immunization program is recognized globally, with certifications for polio-free status, rubella and congenital rubella syndrome control, hepatitis B control, and maternal and neonatal tetanus elimination [14] - In Nepal, a campaign successfully vaccinated 1.4 million (1,400,000) eligible girls with the HPV vaccine within 2 weeks [23] - Disinformation and fake news on social media posed a challenge, requiring proactive fact-checking and counter-messaging [25][27]