Summary of TransMedics Group (TMDX) FY Conference - June 09, 2025 Company Overview - **Company**: TransMedics Group (TMDX) - **Industry**: Organ transplantation technology and services Core Points and Arguments 1. **Unique Position in Organ Transplantation**: TransMedics operates in the organ transplantation field, addressing the limitations of traditional cold storage methods for organs, which have historically led to underutilization of donor organs [5][7][8] 2. **Organ Care System (OCS)**: The company developed the Organ Care System, which keeps organs metabolically active and oxygenated during transport, significantly improving organ viability and utilization rates [8][10][16] 3. **Impact on Transplant Volumes**: TransMedics has achieved double-digit growth in national transplant volumes for heart and liver, a first in three decades [10][11] 4. **National OCS Program (NOP)**: The NOP integrates logistics and service components, managing the entire process from organ donation to transplantation, which has become the primary business model for TransMedics [12][13] 5. **Clinical Evidence**: The OCS has demonstrated an 80-85% utilization rate for previously rejected organs and the best clinical outcomes in organ transplantation history [16][20] 6. **DCD Donors**: TransMedics has pioneered the use of donors after circulatory death (DCD), which now represents nearly 50% of the U.S. transplant donor population, a significant increase from previous years [23][24] 7. **Future Growth Projections**: The company aims to reach 10,000 transplants by 2028, with plans to expand to 20,000-30,000 transplants by introducing kidney transplantation technology [30][31] 8. **International Expansion**: While currently a small part of the business, international markets are expected to grow significantly as reimbursement processes improve [38][57] Financial Outlook 1. **Revenue Projections**: The company anticipates reaching approximately $11.2 billion in revenue upon achieving the 10,000 transplant goal, with an operating margin target of 30% by 2028 [43][45] 2. **Gross Margin Expectations**: Long-term gross margins are expected to stabilize around 60%, with operating expenses being the primary lever for achieving the desired operating margin [47][48] 3. **R&D Investments**: Continued investment in R&D is planned to support the development of next-generation OCS technology and the kidney program, with R&D growth expected to outpace sales growth [50][51] Additional Important Insights 1. **Economic Value to Hospitals**: TransMedics provides significant economic benefits to transplant programs by increasing transplant volumes and reducing post-transplant complications, while also waiving costs if organs are not transplanted [65][67] 2. **Physician Benefits**: The NOP allows for more scheduled morning transplants, improving work-life balance for physicians and enhancing overall transplant program efficiency [69][70] 3. **Reimbursement Landscape**: The U.S. reimbursement model for organ transplantation is favorable, with separate budgets for organ acquisition costs, which supports the financial viability of TransMedics' services [56][58] This summary encapsulates the key points discussed during the conference, highlighting TransMedics' innovative approach to organ transplantation, its growth strategies, and the financial outlook for the company.