Core Viewpoint - Guggenheim initiated coverage of Rapt Therapeutics Inc. with a Buy rating and a $70 price target, driven by optimism regarding the company's lead anti-IgE antibody program and growth potential in the food allergy treatment market [1] Company Highlights - Rapt's long-acting anti-IgE monoclonal antibody, RPT-904, is highlighted as a key differentiator, featuring a YTE mutation that extends its half-life to approximately three times that of Roche's Xolair, the first-generation anti-IgE treatment recently approved for food allergies [2] - RPT-904 is expected to provide a significant convenience advantage due to its less frequent dosing, which is particularly beneficial for the pediatric population, as most food allergy patients are children [3] Market Potential - Guggenheim estimates that RPT-904 could address 20–30% of the patient population currently ineligible for Xolair due to high IgE levels or weight restrictions [4] - A Phase IIb trial with around 100 participants is anticipated to start in 2026, with data expected in the first half of 2027 [4] - If approved, peak sales for RPT-904 in food allergy indications are projected to be approximately $2.1 billion, indicating substantial upside potential given Rapt's enterprise value near $765 million [4]

Financial Data and Key Metrics Changes - The company reported $170 million in cash at the end of Q2, which is expected to last through the second half of 2027, coinciding with the anticipated Phase IIb food allergy readout top-line data [73]. Business Line Data and Key Metrics Changes - RAPT Therapeutics is focused on RPT-904, a next-generation long-acting anti-IgE antibody, which is in Phase II development and targets food allergies and chronic spontaneous urticaria (CSU) [4][6]. - The food allergy market is valued at $40 billion in the United States, while CSU represents a $5 billion market [6]. Market Data and Key Metrics Changes - Xolair, a competitor drug, has approximately 60,000 patients in the food allergy indication and is growing rapidly, indicating a significant unmet medical need in this area [10][11]. - There are about 17 million food allergy patients in the United States, comparable to the number of atopic dermatitis patients [11]. Company Strategy and Development Direction - The company aims to differentiate RPT-904 from Xolair by offering similar efficacy with less frequent dosing (Q8 or Q12 weeks compared to Xolair's Q2 or Q4 weeks) [34][35]. - RAPT Therapeutics plans to initiate a Phase 2b study for food allergies before the end of the year, following a design similar to the OUTMATCH study that led to Xolair's approval [60][65]. Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential of RPT-904 to meet the needs of patients currently ineligible for Xolair therapy, filling a significant gap in treatment options [33]. - The company is optimistic about the upcoming data from GeminCare's studies, which could accelerate their timeline to market for CSU [40][46]. Other Important Information - The patent for omalizumab (Xolair) is set to expire later this year, leading to expectations of price erosion for the branded product [15][16]. - RAPT Therapeutics is collaborating with GeminCare, a multibillion-dollar Chinese pharmaceutical company, to support the development of RPT-904 [38]. Q&A Session Summary Question: What is the expected market presence for ZOLIER biosimilars? - The patent on omalizumab expires later this year, with biosimilars expected to enter the market in the latter part of next year, leading to anticipated price erosion of branded Omalizumab [15][16]. Question: What is the strategy for positioning RPT-904 against ZOLIER biosimilars? - The company aims for omalizumab-like efficacy and safety with dosing every eight weeks as the base case, and every twelve weeks as the upside case [34][35]. Question: What does success look like for the CSU readout? - Success is defined as achieving omalizumab-like efficacy at Q8 week dosing, with the potential for Q12 week dosing to command a premium price [52]. Question: What is the rationale for conducting a PKPD study? - The PKPD study aims to confirm that the pharmacokinetics and pharmacodynamics observed in healthy volunteers will extrapolate to patients with higher IgE levels [42]. Question: What is the expected timeline for the Phase IIb food allergy study? - The Phase IIb study is on track to start before the end of the year, with initial interactions with the FDA having gone well [65].