Core Insights - The research team from Nanjing Agricultural University and the Shenzhen Agricultural Genomics Institute has developed the largest potato disease resistance gene resource library, successfully cloning three novel late blight resistance genes and proposing a new "plug-in" breeding strategy for disease resistance [1][2] Group 1: Research Achievements - The team constructed a pan-genome of potato containing 39,211 intracellular disease resistance receptor genes, making it the largest and most comprehensive disease resistance gene resource library in the plant kingdom [2] - Three novel late blight resistance genes were successfully cloned, providing resources for precise breeding against potato late blight [2] Group 2: Breeding Strategy - The innovative "domain plug-in" breeding strategy involves grafting functional domains of resistance genes from wild potatoes onto the end of the ineffective late blight resistance gene R1, allowing it to recognize both AVR1 and AVRbrk1 pathogen effector proteins [2] - This "plug-and-play" gene design approach offers a new pathway for rapidly creating broad-spectrum disease-resistant varieties [2] Group 3: Economic Impact - Potato late blight poses a significant threat to food security, causing nearly $10 billion in economic losses annually, highlighting the urgency for new resistance gene resources and innovative breeding strategies [1]