Core Insights - CRISPR Therapeutics has entered a collaboration with Sirius Therapeutics to develop and commercialize novel siRNA therapies, specifically targeting thromboembolic disorders [1][3] - The lead candidate from this partnership, SRSD107, has shown promising results in early studies, indicating potential as a best-in-class therapy for thromboembolism [5][6] Financial Terms of the Collaboration - CRISPR Therapeutics will make an upfront cash payment of $25 million and $70 million in equity to Sirius Therapeutics, with both companies sharing development costs and profits equally [3][4] - CRISPR will handle commercialization in the U.S., while Sirius will lead in Greater China [3] Development Status of SRSD107 - Phase I studies have demonstrated over 93% peak reductions in FXI levels and activity, with a significant increase in activated partial thromboplastin time [5] - A Phase II study has been initiated to evaluate the safety and efficacy of SRSD107 for preventing venous thromboembolism in patients undergoing total knee arthroplasty [6] Recent Achievements - CRISPR Therapeutics, in partnership with Vertex Pharmaceuticals, received approval for Casgevy, a CRISPR/Cas9 gene-edited therapy for sickle cell disease and transfusion-dependent beta thalassemia, marking a significant milestone in medical science [8] - Vertex leads the global development and commercialization of Casgevy, sharing costs and profits with CRISPR in a 60:40 ratio [9]