Financial Performance - Total revenue increased to $132 million in Q3 2025, a 14% year-over-year growth compared to $116 million in Q3 2024[10] - Testing revenue reached $128 million in Q3 2025, a 17% year-over-year increase from $110 million in Q3 2024[10] - Adjusted EBITDA margin was 30.1% in Q3 2025, compared to 23.6% in Q3 2024[34] - The company raised full-year revenue guidance to $506 - $510 million and adjusted EBITDA margin expectations to over 25%[36] - Cash and short-term investments increased to $366 million at the end of Q3 2025, compared to $274 million in Q3 2024[34] Testing Volume and Growth - Testing volume increased to 43,700 in Q3 2025, a 19% year-over-year growth compared to 36,800 in Q3 2024[10] - Decipher test quarterly volume continued to grow, with a 26% increase[16] - Afirma test quarterly volume also experienced growth, with a 13% increase[21] Strategic Initiatives and Product Development - The company is transitioning to v2 Veracyte transcriptome to improve operational efficiency[14] - Commercial launch of TrueMRD for muscle invasive bladder cancer (MIBC) is on track for the first half of 2026[25] - Prosigna LDT launch is on track for mid-2026 in the CLIA lab[26]

Financial Data and Key Metrics Changes - The company reported total revenue of $130 million for Q2 2025, reflecting a 14% year-over-year growth [8][31] - Testing revenue also grew by 14% year-over-year, amounting to $122.3 million, driven by significant growth in Decipher and Afirma [31] - Adjusted EBITDA margin reached 27.5%, significantly exceeding expectations [9][35] - Non-GAAP gross margin was 71.5%, up approximately 30 basis points compared to the prior year [33] Business Line Data and Key Metrics Changes - Decipher tests delivered approximately 25,500 tests, achieving a year-over-year volume growth of 28% [10][11] - Afirma volume growth increased by 8% year-over-year, resulting in approximately 16,950 tests [17] - Prosigna is set to launch as an LDT in the U.S. breast cancer market in mid-2026, targeting a large patient population [21][22] Market Data and Key Metrics Changes - The company believes it holds a 65% market share in the prostate testing market, with Decipher positioned as the leading brand among clinicians [16] - The NCCN high-risk patient population is estimated to be approximately 25% of the incidence population, indicating a significant growth opportunity [13] Company Strategy and Development Direction - The company aims to transform cancer care globally through strategic initiatives focused on short-term, mid-term, and long-term growth drivers [9][29] - Plans include expanding the MRD testing platform and launching innovative products like the Percepta nasal swab for lung cancer [23][28] - The company is committed to geographic expansion and enhancing its research and development capabilities [26][27] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in Decipher's long-term growth trajectory, anticipating sustained double-digit growth driven by market penetration and share gains [16][55] - The company expects to generate approximately $13 million in savings compared to 2024 results, which will be reinvested in growth drivers [37] - The updated 2025 total revenue guidance is set at $496 million to $500 million, reflecting strong performance in the first half of the year [38] Other Important Information - The company has scanned over 90,000 slides from over 50,000 de-identified patients to support ongoing research in digital pathology [15][104] - The sale of the Veracyte SaaS manufacturing business was completed on August 1, allowing for continuity of supply for the Prosigna IVD [26][36] Q&A Session Summary Question: What are the key drivers for maintaining Decipher's growth? - Management highlighted market penetration, share gains, and digital pathology integration as key drivers for sustaining growth [45][49] Question: What is the expected growth contribution from the metastatic population for Decipher? - Management indicated that while the metastatic launch is promising, it is not expected to have a significant impact in 2025, with more substantial contributions anticipated in 2026 and beyond [58][65] Question: What milestones will drive greater adoption and revenue growth for Prosigna? - Key milestones include the mid-2026 launch, pivotal study results, and ongoing clinical studies to support the test [67][68] Question: How is the company approaching MRD testing? - The company plans to leverage its existing Decipher sales channel and cross-train sales representatives to target both academic and community oncology [79][80] Question: What feedback has been received regarding the digital pathology offering? - Initial feedback has been positive, with a focus on ensuring that digital pathology complements existing molecular diagnostics [100][102]