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Innovent Announces Mazdutide Received Approval from China's NMPA for Glycemic Control in Adults with Type 2 Diabetes
Prnewswire· 2025-09-19 10:01
Core Insights - Innovent Biologics has received approval from China's National Medical Products Administration (NMPA) for mazdutide, a first-in-class dual glucagon (GCG)/glucagon-like peptide-1 (GLP-1) receptor agonist, aimed at glycemic control in adults with type 2 diabetes (T2D) [1][6][16] - Mazdutide is expected to provide comprehensive benefits in glycemic control, weight reduction, and improvements in hepato-cardio-renal metabolic indicators, addressing the urgent need for effective diabetes management in China [5][9][11] Industry Context - China has the highest prevalence of T2D globally, with approximately 140 million adults affected, representing 1 in 4 cases worldwide [2][12] - The treatment paradigm for diabetes is shifting towards a comprehensive, patient-centric management strategy that includes glycemic control, weight management, and cardiovascular risk factor mitigation [3][10] Clinical Evidence - The approval of mazdutide was based on two Phase 3 clinical trials (DREAMS-1 and DREAMS-2), which demonstrated its superiority over placebo and dulaglutide in glycemic control and weight reduction [6][7][11] - In DREAMS-1, at Week 24, the mean changes in HbA1c for the mazdutide 4 mg and 6 mg groups were -1.57% and -2.15%, respectively, compared to -0.14% for placebo [6] - In DREAMS-2, at Week 28, the mean changes in HbA1c for the mazdutide 4 mg and 6 mg groups were -1.69% and -1.73%, respectively, compared to -1.38% for dulaglutide [6] Safety and Administration - Mazdutide exhibited a safety profile consistent with previous GLP-1 receptor agonists, with no new safety signals identified [7] - The mazdutide injection device features significant improvements in convenience and safety, including a hidden needle design and single-use functionality, enhancing patient comfort and adherence [8] Future Implications - The approval of mazdutide aligns with the "Healthy China 2030" vision, aiming to improve disease management and reduce the burden of T2D in the population [5][11] - Innovent Biologics has plans for further clinical studies and potential new indications for mazdutide, indicating a commitment to advancing diabetes treatment options [14][15]
Fangzhou Posts Strong 1H Revenue and Profit as Physician Network and User Base Expand
Globenewswire· 2025-08-27 15:52
Core Viewpoint - Fangzhou Inc. reported a profitable first half of 2025, driven by an expanding user base, improved operating efficiency, and accelerated AI deployment in healthcare services and internal operations [1] Financial Performance - Revenue for the first half of 2025 reached RMB 1.494 billion, marking a 12.9% increase year-on-year [2] - Net profit was RMB 12.5 million, a significant turnaround from a loss of RMB 818.7 million in the same period last year [2] - Adjusted net profit increased by 16.8% to RMB 17.6 million, achieving a new high [2] User Growth - Registered users on the platform grew by 15.8% year-on-year to 52.8 million [3] - Monthly active users surged by 34.4% to 11.9 million [3] - The number of registered doctors increased to 229,000, with a paid user repurchase rate of 85.4%, indicating strong user retention [3] Revenue Breakdown - Revenue from online retail pharmacy services rose by 28.2% to RMB 864 million [4] - Revenue from medical services increased by 11.4% to RMB 357 million [4] - The drug catalog expanded to 215,000 SKUs, with prescription medicines making up approximately 62% [4] Product Innovation - The company launched several innovative drugs through its platform from leading pharmaceutical companies, including Novo Nordisk and Novartis AG [5] AI Integration - Fangzhou accelerated the implementation of AI across various functions, enhancing user services, procurement, marketing, and content production [6] - The upgraded "AI+H2H" platform supports immediate health consultations and long-term disease management, with AI tools assisting doctors and patients [7] - Internally, AI tools were deployed for procurement and content creation, improving operational efficiency [8] Strategic Expansion - The company is enhancing integration with China's national medical insurance system, improving service capabilities for insured patients [9] - Future plans include a "technology innovation + digital integration" strategy, focusing on deeper AI integration and collaboration with drugmakers and health institutions [10] Company Overview - Fangzhou Inc. is a leading online chronic disease management platform in China, serving 52.8 million registered users and 229,000 physicians as of June 30, 2025 [11]