Core Insights - Aclarion, Inc. has announced the publication of a featured article in the Special Pain Issue of the International Journal of Spine Surgery, highlighting the importance of understanding pain as a complex condition and showcasing their Nociscan solution for chronic low back pain [1][2][4] Company Overview - Aclarion is a healthcare technology company focused on leveraging biomarkers and proprietary AI algorithms to assist physicians in identifying chronic low back pain locations [1][6] - The company’s Nociscan solution is the first evidence-supported SaaS platform designed to noninvasively differentiate between painful and nonpainful discs in the lumbar spine [2][7] Product Details - Nociscan utilizes Magnetic Resonance Spectroscopy (MRS) data to extract and quantify chemical biomarkers associated with disc pain, providing critical insights for treatment optimization [6][7] - A case study featured in the publication demonstrated Nociscan's effectiveness in identifying the source of pain, leading to successful surgical intervention for a patient [3][4] Industry Context - The Special Pain Issue of IJSS emphasizes the evolving understanding of pain, integrating objective biomarkers with clinical judgment to enhance diagnosis and treatment [2][4] - IJSS is recognized for advancing scientific and clinical excellence in spine care, publishing over 150 articles annually from over 40 nations [4][6]

Core Insights - Aclarion, Inc. presented its Nociscan® solution at the ISPN Annual Meeting, emphasizing its role in diagnosing chronic low back pain through disc chemistry analysis [1][5] - Nociscan is the first evidence-supported SaaS platform that noninvasively differentiates between painful and non-painful discs in the lumbar spine, providing actionable insights for personalized treatment [2][4] Company Overview - Aclarion is a healthcare technology company focused on chronic low back pain, utilizing Magnetic Resonance Spectroscopy (MRS) and proprietary AI algorithms to optimize clinical treatments [4][6] - The company aims to establish Nociscan as the gold standard for identifying sources of chronic low back pain, addressing a global issue affecting over 266 million people [5][6] Technology and Innovation - Nociscan converts MR spectroscopy signals into objective biomarkers associated with disc pain, enabling physicians to develop tailored treatment plans [2][6] - The technology employs proprietary signal processing techniques to extract and quantify chemical biomarkers, enhancing diagnostic clarity for physicians [6] Industry Engagement - Aclarion's participation in esteemed academic society meetings like ISPN highlights its commitment to innovation in the spine surgery and pain management ecosystem [3] - The panel discussion at ISPN underscored the importance of multidisciplinary approaches in diagnosing and treating back pain, showcasing Aclarion's collaborative efforts with leading experts [3][5]

Core Insights - Aclarion, Inc. announced the addition of Keck Medical Center of USC as a site for the CLARITY trial, aimed at demonstrating the clinical and economic value of Nociscan in spine surgery [1][2] - The CLARITY trial will evaluate 300 patients undergoing surgical treatment for discogenic low back pain, with a primary endpoint of measuring changes in back pain at 12 months [3][4] Company Overview - Aclarion is a healthcare technology company utilizing biomarkers and AI algorithms to assist physicians in identifying chronic low back pain [1][6] - Nociscan is the first evidence-supported SaaS platform designed to noninvasively differentiate between painful and nonpainful discs in the lumbar spine [4][6] Trial Details - The CLARITY trial is a prospective, randomized multi-center study involving multiple high-volume sites across the US, including notable institutions like Johns Hopkins Medicine and Northwestern Medicine [2][3] - The trial will randomize patients in a 1:1 ratio between surgeons who are blinded and unblinded to Nociscan results [3] Market Context - Chronic low back pain affects approximately 266 million people globally, highlighting a significant healthcare challenge [4] - Aclarion's Nociscan aims to improve surgical outcomes by providing insights into the sources of low back pain through advanced diagnostic techniques [4][7]

Core Insights - Aclarion, Inc. announced the addition of Advocate Aurora Research Institute as a site for the CLARITY trial, which aims to demonstrate the clinical and economic value of its Nociscan platform in spine surgery [1][4][5] Company Overview - Aclarion is a healthcare technology company focused on chronic low back pain, utilizing biomarkers and proprietary AI algorithms to assist physicians in identifying pain sources [1][5][8] - The Nociscan platform is the first evidence-supported SaaS solution designed to noninvasively differentiate between painful and non-painful discs in the lumbar spine [5][8] CLARITY Trial Details - The CLARITY trial is a prospective, randomized multi-center study involving 300 patients scheduled for surgical treatment of 1- or 2-level discogenic low back pain [4] - The trial will randomize patients at a 1:1 ratio between surgeons blinded to Nociscan results and those unblinded, with the primary endpoint being the change in back pain measured on a 100mm VAS at 12 months [4][5] - The principal investigator is Dr. Nicholas Theodore from Johns Hopkins Medicine [4] Market Context - Chronic low back pain affects approximately 266 million people globally, highlighting a significant healthcare challenge [5] - Traditional imaging methods often fail to clearly identify the source of pain, which Nociscan aims to address by providing insights into disc pain [5][8]

Core Insights - Aclarion, Inc. is a healthcare technology company focused on chronic low back pain, utilizing biomarkers and proprietary AI algorithms to assist physicians in identifying pain sources [1][3] - The company plans to file its 10K report by the end of March, which will include a more detailed corporate update [2] Company Overview - Aclarion leverages Magnetic Resonance Spectroscopy (MRS) and proprietary signal processing techniques to optimize clinical treatments [3] - The company's primary product, Nociscan, is a SaaS platform designed to noninvasively differentiate between painful and nonpainful discs in the lumbar spine [3] - Nociscan processes MRS data from MRI machines to extract and quantify chemical biomarkers associated with disc pain, providing critical insights for treatment optimization [3]

Table of Contents (Exact name of registrant as specified in its charter) As filed with the Securities and Exchange Commission on January 31, 2024 Registration No. 333-276648 (State or other jurisdiction of incorporation or organization) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 (Primary Standard Industrial Classification Code Number) FORM S-1/A Pre-Effective Amendment No. 1 Delaware 8071 47-3324725 (I.R.S. Employer Identification Number) REGISTRATION STATEMENT UNDER THE SECURIT ...

Table of Contents As filed with the Securities and Exchange Commission on October 10, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Aclarion, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 8071 47-3324725 (I.R.S. Employer Identification Number) (Addres ...

Table of Contents As filed with the Securities and Exchange Commission on July 12, 2023 Registration No. 333-273113 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO (Primary Standard Industrial Classification Code Number) Delaware 8071 47-3324725 (I.R.S. Employer Identification Number) 8181 Arista Place, Suite 100 Broomfield, Colorado 80021 (833) 275-2266 (Address, including zip code, and telephone number, including area code, of registrant's principal executive off ...