We analyse which countries have the easiest and toughest access to the world’s biggest market https://t.co/AZonTvreTx https://t.co/vaUqTupW19 ...

We analyse which countries have the easiest and toughest access to the world’s biggest market https://t.co/Fn4PFkTD2w ...

Trade Relations - Thailand pledged near-total market access for US goods to President Trump [1] - The pledge includes key limits to protect some domestic industries [1]

Well, the agreement with the EU and US is far from final, as we just were talking about, with many details still to be ironed out. Meanwhile, US negotiators are jumping right into their next big round with China. Talks with that country began in Stockholm today.Joining us now, Zoe Lou, Council on Foreign Relations senior fellow, as well as Terry Haynes, Pangia policy founder, and Yahoo Finances Washington correspondent Ben Worskll. Ben, let's start with you here. We've got this deal with the EU.Now, they're ...

美国商务部长卢特尼克：我们希望打开中国非敏感产品市场。 ...

Thailand is weighing allowing zero-duty market access for more US goods to help persuade the Trump administration to lower a threatened 36% tariff on its exports https://t.co/hFQL6b71yp ...

Thailand is making a last-ditch effort to avert a punitive 36% export levy with offers of greater market access for US farm and industrial goods https://t.co/eKwocWnWaM ...

Teva Pharmaceutical Industries (TEVA) 2025 Conference Summary Company Overview - Teva Pharmaceutical Industries is focusing on a growth strategy initiated in 2023, emphasizing innovative medicines, pipeline advancements, generics, and business focus [2][3] Key Business Developments - Teva has experienced nine consecutive quarters of growth and is entering a new acceleration phase from 2025 to 2027 [3] - Key commercial assets include AUSTEDO, Yuzetti, and AJOVY, which are significant drivers for the company [3] AUSTEDO Insights - AUSTEDO is projected to achieve peak sales of over $3 billion, driven by an unmet need in the treatment of tardive dyskinesia (TD) [6][7] - Approximately 800,000 patients in the U.S. have TD, with only 15% diagnosed and 5-6% currently treated, indicating a substantial market opportunity [7] - AUSTEDO has seen 40% growth and 23% increase in total prescriptions (TRxs) [7] - Teva has invested in direct-to-consumer marketing to raise awareness and has filed for approval in Europe [8] Competitive Landscape - Teva views the competition with Neurocrine's INGREZZA as a collaborative effort to increase patient treatment rather than direct competition [9] - AUSTEDO maintains broad coverage, with patients paying an average of less than $10 out of pocket [10] Long-Acting Injectable (LAI) Developments - Teva is excited about the EZEDI long-acting injectable, which offers significant advantages for patient compliance and rapid relief [15][16] - The company aims to capture market share from existing LAIs like risperidone and paliperidone [16][19] - The long-acting olanzapine is expected to have a favorable launch trajectory, potentially faster than Yuzetti due to pent-up demand [20][21] TL1A Pipeline - TL1A is a promising new biologic targeting inflammatory pathways, with potential applications in ulcerative colitis and Crohn's disease [35][36] - The molecule has shown high efficacy in Phase II studies, with low rates of anti-drug antibodies [37][38] - Upcoming data updates are expected in the first half of 2026, focusing on maintenance data [40][41] DARE Program - The Dual Action Rescue Inhaler (DARE) targets the significant unmet need in asthma exacerbations, with a focus on combination therapies [57][58] - Teva is conducting the largest asthma study to date, aiming for broad labeling that includes pediatric populations [59][60] Market and Regulatory Considerations - Teva is actively managing tariff exposure, with a strong manufacturing presence in the U.S. and limited exposure to China and India [65][66] - The company has taken proactive measures to ensure inventory levels are sufficient to navigate potential market disruptions [67] Conclusion - Teva is positioned for growth with a robust pipeline and strategic focus on innovative therapies, while navigating competitive and regulatory landscapes effectively. The company remains committed to addressing significant unmet medical needs across its product offerings.

Financial Data and Key Metrics Changes - The company reported total revenues of $197.1 million for Q1 2025, representing a year-over-year increase of 43% on an as-reported basis and 32% on an organic basis [8][28] - Adjusted non-GAAP EBITDA was $50.7 million, compared to $37.6 million in the prior year period, reflecting strong operational performance [32] - Adjusted non-GAAP EPS for the quarter was $1.7, up from $1.21 in the prior year period [32] Business Line Data and Key Metrics Changes - Revenues from the rare disease segment were $69 million, up 87% from the prior year, driven by strong performance of Cortrophin Gel, which generated $52.9 million in revenues, a 43% increase [29][30] - The generics segment reported revenues of $98.7 million, an increase of 41% year-over-year, attributed to new product launches and strong execution in the base business [14][30] - Revenues from the brands portfolio were $25.1 million, a slight decrease of 2% from the prior year [29] Market Data and Key Metrics Changes - The overall ACTH category grew 27% to approximately $684 million in 2024, indicating a favorable market environment for Cortrophin Gel [9] - The company expects Cortrophin Gel revenues to increase by 34% to 38% in 2025, projecting revenues of $265 million to $274 million [10][33] - The retina products, ILUVIEN and YUTIQ, generated revenues of $16.1 million in Q1, with performance impacted by market access challenges for Medicare patients [11][29] Company Strategy and Development Direction - The company is focused on expanding its rare disease business, particularly through Cortrophin Gel, and is investing in evidence generation and new product presentations to enhance market penetration [19][20] - A bespoke commercial approach is being implemented to address market access challenges, particularly for ILUVIEN and YUTIQ, with plans to enhance sales force capabilities [24][25] - The company is committed to maintaining a strong U.S. manufacturing footprint, with over 90% of revenues coming from domestically produced goods, positioning itself favorably in light of potential pharmaceutical tariffs [16][94] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth trajectory of Cortrophin Gel, citing a significant unmet medical need and a large addressable patient population [19][64] - The company anticipates a return to sequential revenue growth in the latter half of 2025, following a strong first quarter performance [34] - Management acknowledged challenges in the retina segment but highlighted positive trends in demand and a strengthened sales team as factors that will support future growth [13][53] Other Important Information - The company is preparing for an upcoming trial with CG Oncology regarding a royalty obligation dispute, with the jury trial set to commence on July 21, 2025 [36][38] - The company has a strong balance sheet with $149.8 million in unrestricted cash and a gross leverage ratio of 3.5 times [32] Q&A Session Summary Question: How much should the prefilled syringe help Cortrophin? - Management noted that early responses to the prefilled syringe have been positive, as it reduces one step in the administration process, and they expect to see traction as the year progresses [42][43] Question: What gives confidence in accelerating ILUVIEN and YUTIQ sales? - Confidence is based on several factors, including performance outside the U.S., improvements in sales force strength, and positive impacts from a bespoke commercial approach [51][52] Question: What are the payer dynamics for Cortrophin as the category returns to growth? - Management indicated that payers appreciate the competition brought to the category and that collaboration will continue to ensure patient access [82] Question: How is the acquisition of Alimera performing? - Management expressed confidence in the long-term opportunity for ILUVIEN and YUTIQ, highlighted by the recent buyout of a royalty obligation [84]

Financial Data and Key Metrics Changes - The company reported total revenues of $197.1 million for Q1 2025, representing a year-over-year increase of 43% on an as-reported basis and 32% on an organic basis [7][29] - Adjusted non-GAAP EBITDA was $50.7 million, compared to $37.6 million in the prior year period, reflecting strong operational performance [33] - Adjusted non-GAAP EPS for the quarter was $1.70, up from $1.21 in the prior year [33] Business Line Data and Key Metrics Changes - Revenues from the rare disease segment were $69 million, up 87% from the prior year, driven by strong performance of Cortrophin Gel, which generated $52.9 million in revenues, a 43% increase [30][33] - The generics segment reported revenues of $98.7 million, an increase of 41% year-over-year, attributed to new product launches and strong execution in the base business [14][31] - Revenues from the brands portfolio were $25.1 million, a decrease of 2% from the prior year, indicating a return to more normalized demand levels [30] Market Data and Key Metrics Changes - The overall ACTH category grew 27% to approximately $684 million in 2024, with Cortrophin Gel capturing a significant share of new prescribers [9][10] - The company expects Cortrophin Gel revenues to increase by 34% to 38% in 2025, reaching $265 million to $274 million [10][36] - The retina products, ILUVIEN and YUTIQ, generated revenues of $16.1 million in Q1, with expectations of $97 million to $103 million for the full year [10][36] Company Strategy and Development Direction - The company is focused on expanding its rare disease business, particularly through Cortrophin Gel, and is investing in new clinical trials to support its growth trajectory [20][28] - A strategic emphasis is placed on enhancing market access for ILUVIEN and YUTIQ through specialty pharmacies and Medicare Part D options [23][24] - The company is committed to maintaining a strong U.S. manufacturing footprint, with over 90% of revenues coming from domestically produced goods [16][90] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth potential of Cortrophin Gel, citing a significant unmet medical need and a large addressable market [19][20] - The company anticipates a return to sequential revenue growth in the latter half of 2025, following a modest decline in Q2 [36] - Management acknowledged challenges in the retina segment due to market access issues but remains optimistic about recovery and growth in the second half of the year [11][56] Other Important Information - The company raised its 2025 guidance for total revenues and adjusted non-GAAP EBITDA based on strong Q1 performance and favorable demand trends [7][36] - The company has a strong balance sheet with $149.8 million in unrestricted cash and a gross leverage ratio of 3.5 times [33][34] - The company is preparing for an upcoming trial against CG Oncology regarding a royalty obligation dispute [38][39] Q&A Session Summary Question: How much should the prefilled syringe help Cortrophin? - Management noted that early responses to the prefilled syringe have been positive, as it reduces administration steps, and they expect to update on its progress soon [44] Question: What gives confidence in accelerating ILUVIEN and YUTIQ sales? - Confidence is based on performance outside the U.S., improvements in the sales force, and positive April results from a bespoke commercial approach [54][56] Question: Can you elaborate on the commercial challenges impacting ILUVIEN? - Challenges stemmed from a lack of funding for co-pay support for Medicare patients, affecting access to therapy [62] Question: What indications are driving growth for Cortrophin? - Growth is seen across all specialties, with significant contributions from nephrology, rheumatology, and ophthalmology [88] Question: How does the company view the acquisition of Alimera? - Management remains confident in the long-term opportunity for ILUVIEN and YUTIQ, as evidenced by the recent buyout of a royalty obligation [82]