Summary of Zymeworks Conference Call Company Overview - **Company**: Zymeworks - **Event**: 44th JPMorgan Healthcare Conference - **CEO**: Ken Galbraith Key Points Company Transformation and Strategy - Zymeworks experienced a transformative year, highlighted by the readout of the Horizon-GEA-01 study for zanidatamab, which is expected to become the new standard of care in HER2-overexpressing gastric and esophageal adenocarcinoma (GEA) [2][4] - The company is evolving its strategy to leverage the success of zanidatamab and create shareholder value through innovative approaches beyond traditional R&D [4][6] - Leadership changes have been made to align the team with the new strategic direction [5] Financial Position and Future Outlook - Zymeworks has a strong financial foundation, with expectations of excess cash flow rather than cash flow issues, allowing for a long-term focus on shareholder value [12][22] - The company anticipates significant appreciation in stock value as zanidatamab continues to succeed and other agents progress [12][14] - The partnership with Jazz Pharmaceuticals and B1 is crucial for capital and development capabilities, enhancing the potential for zanidatamab's success [11][22] Product Development and Competitive Landscape - Zanidatamab is positioned as a superior HER2-targeted agent compared to trastuzumab, with promising clinical data supporting its efficacy [32][34] - The competitive landscape has shifted favorably for zanidatamab, as competitors have faced challenges in their clinical trials [33][36] - Zymeworks is exploring additional indications for zanidatamab and other products, including JNJ-64264681, which is expected to be a significant revenue generator [15][36] Royalty and Partnership Strategy - The company is focused on holding onto royalty streams from zanidatamab and other products, believing this approach will maximize long-term value for shareholders [29][50] - Zymeworks is open to monetizing royalties but seeks fair value, indicating a strategic approach to partnerships and asset management [49][51] - The company aims to build a portfolio of high-quality royalty streams, enhancing its financial stability and growth potential [50][53] Research and Development Focus - Zymeworks continues to invest in R&D, with a focus on innovative biologics and antibody-drug conjugates [23][24] - The company is exploring new product opportunities, including bispecific antibodies and ADCs, while maintaining a unique position in the market [65] Future Expectations - Zymeworks plans to present further data and updates on its pipeline in the coming year, aiming to exceed current expectations [25][26] - The company is committed to innovation and leveraging its scientific expertise to drive future successes [23][24] Additional Insights - The CEO emphasized the importance of adapting strategies to ensure continued success in a competitive biotech landscape, highlighting the need for flexibility in product development and partnerships [18][20] - Zymeworks is positioned to capitalize on its unique offerings in the HER2 space, with a differentiated approach that sets it apart from competitors [24][25]

Royalty-driven Model delivers Strong Margin Expansion and Cash Generation; Leadership Transition positions Company for Next Phase of GrowthAll dollar amounts are expressed in Canadian currency(1) Please refer to "non-IFRS and other financial performance measures" in this press release Fiscal 2025 Highlights Record total revenues of $42.8 million, up 8% vs. FY 2024Record royalties of $11 million, up 27% vs. FY 2024Adjusted EBITDA1 of $7.3 million, or 17% of total revenues, up 9 pts vs. FY 2024Net profit of $ ...