Core Insights - The S&P 500 Index has increased over 200% in the last 10 years, but 22 stocks within the index have shown negative total returns during the same period [1][2] - Walgreens Boots Alliance has been identified as the worst performer, with a significant decline in value, leading to its removal from major indexes [4][5] Group 1: S&P 500 Performance - The SPDR S&P 500 ETF Trust SPY has returned 233.7% over the last decade, indicating strong annualized returns for investors [2] - A report highlights that 22 stocks in the S&P 500 Index have negative total returns over the past 10 years [2][3] Group 2: Underperforming Stocks - The 22 underperforming stocks include Walgreens Boots Alliance (-14.2%), Viatris Inc (-12.5%), and PG&E (-10.3%), among others [5] - The sectors most affected include health care, consumer discretionary, consumer staples, and energy, with these sectors appearing frequently among the underperformers [8] Group 3: Recent Developments - Walgreens Boots Alliance is set to be replaced by Interactive Brokers in the S&P 500 Index on August 28 [3] - Despite the long-term declines, 19 of the 22 underperforming stocks had positive returns in August, with seven stocks achieving double-digit gains for the month [7]