Core Argument - The healthcare industry currently focuses on treating chronic diseases rather than preventing them [4] - The industry should shift its focus from disease treatment to investigating resilience, defined as the ability to robustly respond to insult or injury [6] - Centenarians, individuals who live to 100 years or more, exemplify exceptional longevity and provide a blueprint for healthy aging [7] Research & Development - Induced pluripotent stem cells (iPS-CEs) can be used to create disease models and investigate resilience mechanisms [2][8] - Researchers can create "centenarians in a dish" using iPS-CEs from centenarians to study their resistance to aging-related diseases [7][8] - Centenarian neurons exhibit more stable activity, reduced background noise, and operate in a more energy-efficient state compared to normal individuals [12][13] Potential Applications & Future Directions - iPSC master stem cell modeling can identify new biomarkers of aging and facilitate preclinical screening of novel therapeutics aimed at increasing longevity and health span [18] - Developing novel therapeutics ("geroprotectors") can increase resilience and health span, potentially through personalized clinical trials using an individual's own cells [18] - Lifestyle choices such as not smoking, exercising, and practicing preventative medicine can contribute to a more centenarian-like existence [17]

Core Technology & Scientific Advancements - Scientists have developed a technology using human stem cells to grow whole brain organoids, offering potential for brain regeneration [3] - Induced pluripotent stem cells can be generated from various cell types (hair, skin, blood) and differentiated into brain-like structures suitable for transplantation [4] - The developed brain-like structures feature vascular networks crucial for graft survival, formed by smooth muscle cells, pericytes, macrophages, and the immune system [6] - The organoids exhibit cortical layer formation, essential for cognitive functions [7][8] - The organoids demonstrate multi-region integration, communicating and integrating with subcortical regions like the midbrain and hindbrain [8][9] - The brain-like structures exhibit early expression of the blood-brain barrier [10][11] - The integrated organ-like structures communicate through electrical function, indicating functional neural activity [11] Clinical & Translational Potential - Transplantable stem cell lines are already in Phase 2 and Phase 3 clinical trials globally [5] - The technology is reproducible, with 80% reproducibility across multiple cell lines based on marker analysis [9] - Pre-clinical studies in small and large animal models are underway to assess cognitive behavior and structural recovery after injury and potential transplantation [12][13] - The goal is to move the field of transplantation forward and potentially initiate Phase 1 studies within the next five years [15]

[Music] For a long time, I've always thought of as life as a puzzle, but a very special kind of puzzle. A puzzle where we can't see a picture in the box. And why do I say this.So, when we start life, like we're basically just learning new things. We're taking in information from the world. We're seeing the things that we like and the things that we don't like and then we somewhere along the way we come up with our personality or as I would say our way of interacting with the world.So why did I even come up ...

Welcome to my Neuralink update episode. The world's largest company, Apple, doesn't realize yet, but the fact they're playing in the virtual reality space with their Vision Pro product means they're gearing up to compete with Neuralink in the future. But before we think about how that can happen, watch this goofy video clip of someone having their brain fooled in virtual reality.But again, your brain is going to tell you that you're going to feel this. As you can see, as this guy with the hammer starts gent ...