Core Insights - Caris Life Sciences has identified TET2 clonal hematopoiesis (CH) as a promising biomarker for improved response to immune checkpoint inhibitor (ICI) therapy in patients with solid tumors [1][3] - The study, led by Dr. Padmanee Sharma, utilized TET2-mutant laboratory models to explore how these mutations influence immune dynamics within the tumor microenvironment [2] - The research analyzed outcomes from nearly 36,000 non-small cell lung cancer (NSCLC) patients and over 25,000 colorectal cancer (CRC) patients, providing substantial evidence supporting TET2-CH as a potential biomarker for enhanced ICI response [3] Company Overview - Caris Life Sciences is a leading AI TechBio company focused on precision medicine, developing innovative solutions to transform healthcare through comprehensive molecular profiling and advanced AI applications [6] - The company has created a large-scale, multimodal clinico-genomic database to analyze the molecular complexity of diseases, enhancing early detection, diagnosis, monitoring, therapy selection, and drug development [6][7] - Caris operates internationally with offices in multiple locations, including the U.S., Japan, and Switzerland, and aims to realize the potential of precision medicine to improve human health [7]