A trio of scientists from the US and Japan has been awarded the Nobel Prize in medicine. They are Americans Mary Bronco and Fred Ramdell and Japanese scientist researcher Shiman Sakaguchi. They were given the award for their discoveries about how the immune system can be stopped from attacking the body.Their work could lead to new treatments for autoimmune diseases and cancer. They're going to share a prize worth just under $1.2% 2 million. ...

New research backs what Dr. Stanley Appel has thoughts for years — the immune system causes ALS https://t.co/LF6bRierqc ...

A trio of immunologists receive the 2025 award for pioneering discoveries related to the immune system and autoimmune diseases https://t.co/AhCD18rwHM https://t.co/TJw3ZK0938 ...

Recent discoveries have raised the possibility of new cancer-preventing drugs that might help the body better suppress the harmful tendencies of its own immune system. That could be game-changing https://t.co/wr70L426rJ ...

Recent discoveries have raised the possibility of new cancer-preventing drugs that might help the body better suppress the harmful tendencies of its own immune system. That could be game-changing https://t.co/0iw7DF93ZQIllustration: Agnes Jonas https://t.co/1NZEZeZ1h3 ...

Recent discoveries have raised the possibility of new cancer-preventing drugs that might help the body better suppress the harmful tendencies of its own immune system. That could be game-changing https://t.co/gI4YP05OBO ...

Clinical Trial Overview - A clinical trial explored a "one-size-fits-all" vaccine's potential in preventing pancreatic cancer recurrence [1] - The trial included approximately 20 pancreatic cancer patients and 5 colorectal cancer patients, all having undergone standard treatments like chemotherapy and surgery [2] - Patients received six priming doses of an experimental vaccine [2] Vaccine Efficacy and Immune Response - The trial aimed to determine if the cancer vaccine could prevent recurrence and extend recurrence-free survival in patients who had standard treatments [3] - About 85% of individuals who received the cancer vaccine mounted the expected immune response [3] - Approximately two-thirds of the participants exhibited a robust immune response that was still detectable months after therapy, extending their cancer-free survival to about 29 months [3] Vaccine Mechanism and Significance - The cancer vaccine primes the immune system to recognize specific mutations present in cancer cells [5] - It introduces a snippet of a genetic mutation, triggering the immune system to identify and eliminate cells with that mutation [5] - This approach exploits the immune system's ability to kill cancer cells [5] Development Stage and Future Prospects - The trial was an early phase one trial with 25 participants [6] - Further success in phase two and phase three trials is necessary before potential FDA approval [6] - The vaccine targets a genetic mutation not specific to pancreatic or colorectal cancer, making it potentially usable in any cancer with that mutation [8][9]