These forward-looking statements are made as of the date of this press release and we do not intend, and do not assume any obligation, to update these forward-looking statements, except as required by law. We cannot assure you that such statements will prove to be accurate as actual results and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking statements are not guarantees of future performance and accordingly investors are cautione ...

SAN DIEGO and TORONTO, June 30, 2025 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. ("Aptose" or the "Company") (TSX: APS; OTC: APTOF), a clinical-stage precision oncology company developing a tuspetinib (TUS) based triple drug frontline therapy to treat patients with newly diagnosed acute myeloid leukemia (AML), announced that it has entered into an Interest Deferral Agreement (the “Agreement”) with Hanmi Pharmaceutical Co., Ltd. (“Hanmi”), whereby Hanmi has agreed to further defer the interest payment due un ...

Core Insights - Aprea Therapeutics announced promising preclinical data and an initial clinical update for APR-1051, a next-generation oral WEE1 inhibitor targeting HPV+ head and neck squamous cell carcinoma (HNSCC) [1][2] - The findings suggest that APR-1051 may provide significant differentiation in oncology, both as a single agent and in combination with checkpoint inhibitors [2] Preclinical Data - Preclinical studies conducted in collaboration with MD Anderson Cancer Center demonstrated robust antiproliferative effects of APR-1051 across various human and murine head and neck cancer cell lines, with IC₅₀ values ranging from 8.9 to 230 nM [6] - Significant anti-tumor synergy was observed when combining APR-1051 with anti–PD-1 therapies in HPV+ HNSCC models, indicating its potential for combination-based clinical trials [6] - Mechanistically, APR-1051 activates cGAS/STING-mediated immunogenic cell death and exploits the HPV E6-driven G2 checkpoint dependency in HPV+ tumors, highlighting a biomarker-driven strategy for patient selection [6] Clinical Update - In the Phase 1 ACESOT-1051 trial, a 62-year-old male patient with advanced HPV-positive oropharyngeal squamous cell carcinoma showed stable disease and a 5% tumor reduction after treatment with a subtherapeutic 70 mg oral dose of APR-1051 [7] - The patient tolerated the therapy well, with no dose-limiting toxicities reported [7] Future Development - Experts from MD Anderson Cancer Center expressed optimism regarding APR-1051 as a promising addition to the treatment portfolio for HPV-associated head and neck cancers, supported by robust preclinical data [8] - Aprea is committed to advancing APR-1051 as a precision oncology agent, leveraging biomarker insights to optimize patient outcomes [8][9] - Enrollment in the ACESOT-1051 trial is ongoing, with plans to evaluate APR-1051 in combination with checkpoint inhibitors for distinct patient populations [12]

Key Takeaways GH raised 2025 revenue guidance to $880-$890M, driven by rising test volume and ASPs. TEM posted 75% revenue growth and a $200M foundation model deal but remains unprofitable. GH expects breakeven for non-screening ops by Q4 2025, with lower cash burn excluding Shield.Tempus AI (TEM) and Guardant Health (GH) are two dominant players in the field of AI-powered precision oncology. Tempus, newly public and rapidly scaling, reported a 75% year-over-year revenue growth in the first quarter of 202 ...

Carrying a Zacks Rank #3 (Hold) at present, the laboratory service provider is concentrating more on areas that represent major growth opportunities and are expected to grow significantly faster than other therapeutic areas. It maintains a solid pipeline of potential acquisitions that fit its financial strategy and will enhance its organic growth. Additionally, the success of the LaunchPad initiative and a solid financial footing are highly encouraging for the company. Based in Burlington, NC, Labcorp offer ...

The cancer diagnostic firm Caris Life Sciences is set to list on the NASDAQ today. The company actually priced its IPO at $21 a share. That was above its expected range.Joining us right now is David Dean Halbert. He is Caris Life Scienc's founder, chairman, and CEO. And David, welcome.Thank you, Becky. Uh let's talk a little bit about what your company does because it's really interesting AI using life sciences to try and go after identify tumors and and find unique ways to deal with each of those cancer tu ...

I-Mab (IMAB) Conference June 17, 2025 10:00 AM ET Speaker0 Great. We'll get started now. I'd like to welcome everybody to HCW's at home series. Today, we're hosting EyeMed Biopharma. My name is Andres Malvinato. I'm a senior health care analyst here at HC Wainwright, and it's my pleasure to host, you today. And it's my pleasure to introduce, IMAD Biopharma's chief executive officer, Sean Fu, and IMAD's chief medical officer, Philip Dennis. So the crux of our fireside chat will be to give you an overview of ...

BOULDER, Colo., June 13, 2025 /PRNewswire/ -- Enliven Therapeutics, Inc. (Enliven or the Company) (Nasdaq: ELVN), a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule therapeutics, today announced that it has priced its previously announced underwritten public offering of 8,394,737 shares of its common stock at a price to the public of $19.66 per share and, in lieu of common stock to investors who so choose, pre-funded warrants to purchase up to 1,780,263 sha ...

BOULDER, Colo., June 13, 2025 /PRNewswire/ -- Enliven Therapeutics, Inc. (Enliven or the Company) (Nasdaq: ELVN), a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule therapeutics, today announced that it has commenced an underwritten public offering of $200 million of shares of its common stock and, in lieu of common stock to investors who so choose, pre-funded warrants to purchase shares of Enliven's common stock. In addition, Enliven intends to grant the u ...

Prelude Therapeutics (PRLD) 2025 Conference June 05, 2025 03:10 PM ET Speaker0 Alright. Welcome, everyone, to Jeffrey twenty twenty five Healthcare Global Conference. And then my name is Roger Song, one of the senior analysts cover SMICAP biotech in The US. It's my pleasure to have the next fireside chat with Peru Therapeutics. We have the whole team here. We have the CEO, Chris, and then President, then CMO, Jim, and then the CSO, Peggy. Welcome, everyone. Thanks. Awesome. Great. Yeah. Speaker1 Thanks, Rog ...