从传统治疗迈向生物靶向治疗 鼻塞、流脓涕、嗅觉/味觉减退、面部疼痛，你是否正在被这些症状持续困扰？既往流行病学调查显 示，我国慢性鼻窦炎的患病率约有8%，据此估算我国约有1亿患者。其中约2000万-3000万的患者会伴 有鼻息肉，这类患者往往还会伴有哮喘、过敏性鼻炎等共病，严重影响生活质量。 北京同仁医院鼻过敏科副主任张媛在近日接受新京报记者专访时指出，慢性鼻窦炎伴鼻息肉极易复发， 疾病控制难度较大，目前以糖皮质激素为主的药物治疗与手术干预相结合，是该病的核心治疗手段。但 随着生物制剂的使用，该病的管理模式正在改变，为更多患者提供精准、高效的治疗选择，改善长期预 后和生活质量。 鼻窦炎伴鼻息肉易复发，需做好长期疾病管理 "鼻息肉会占据鼻腔正常的呼吸空间以及鼻窦的引流通道，进而引发鼻腔鼻窦的引流障碍并出现一系列 临床症状，严重影响患者的生活质量。"张媛表示，鼻息肉是因黏膜不断水肿脱垂引起的息肉，这个多 出来的"疙瘩"堵塞正常的引流通道，随着鼻腔分泌物不断增多，会引起胀痛、脓涕、嗅觉和味觉障碍 等，形成一个恶性循环。一旦出现嗅觉障碍必须进行积极干预，防止传导性的嗅觉障碍变迁到真正的嗅 觉功能障碍。此外，鼻窦炎伴鼻 ...

Core Viewpoint - The relationship between OpenAI and Microsoft is deteriorating over the definition of Artificial General Intelligence (AGI) and related contract terms, leading to significant disputes that could impact OpenAI's upcoming IPO [1][4]. Group 1: Contract Disputes - OpenAI and Microsoft signed a $10 billion cooperation agreement in 2023, which has triggered major disagreements over the AGI clause [1]. - Microsoft is demanding the removal of a key clause that allows OpenAI to terminate technology access upon achieving AGI, but negotiations remain stalled as of May 2025 [1][2]. - The original 2019 agreement allows OpenAI to cut off Microsoft's access to technology if AGI is reached, a concept that some Microsoft executives view as unrealistic [1][2]. Group 2: AGI Development and Perspectives - OpenAI's CEO Altman claims that AGI is "within reach" and has defined it as a system capable of solving complex human-level problems across multiple domains [2]. - In contrast, Microsoft CEO Nadella argues that a 10% annual growth in the global economy is a more realistic benchmark, suggesting that AGI will not be achieved before the contract expires in 2030 [2]. Group 3: Financial Implications and Negotiation Dynamics - OpenAI is projected to burn through $46 billion in R&D over the next four years, making IPO financing a critical necessity [4]. - If the restructuring fails, the unique equity structure of OpenAI could jeopardize its IPO prospects [4]. - Microsoft has rejected several concessions from OpenAI, including giving up a 20% revenue share and allowing customers to access OpenAI models through competing cloud providers [3]. Group 4: Alliance Fractures - The partnership has seen a shift in power dynamics since the unexpected success of ChatGPT in late 2022, leading to visible fractures in their collaboration [7]. - OpenAI has turned to Google Cloud for computing resources due to insufficient support from Microsoft and has also partnered with Oracle [7]. - Microsoft is accelerating the development of its own AI models and recruiting teams to create alternative solutions [7].

南沙蕉门河畔，小马智行的自动驾驶汽车流畅汇入车流；白云机场停机坪，搭载带电货物的运输包机呼 啸升空；天河路商场内，"丝滑"的离境退税服务让参加完广交会的海外客商直呼"amazing"…… 自2022年12月入选全国服务业扩大开放综合试点城市以来，广州紧扣"服务+"主线，在制度破冰、要素 流动、产业跃迁等领域持续突破，推动服务业扩大开放深度融入经济发展肌理，释放出强劲发展动能。 截至目前，130项试点任务已推进实施128项，实施率达98.5%。涉外法律服务、绿色金融、境外专业人 才服务等13项举措入选全国试点案例，商事登记"跨境通"服务平台试点经验向全国复制推广。服务业增 加值连续两年超2.2万亿元，占GDP比重超70%。试点期间，全市累计新设服务业外商投资企业近1.5万 家，服务贸易突破750亿美元，连续两年呈两位数增长。 产业赋能：服务链与产业链深度共振 探索"服务+制造"，广州展现自动驾驶领域的"湾区速度"。全国首创将"自动驾驶平均脱离间隔里程"纳 入测试标准，开放一般测试道路1340条（单向里程2601公里）、高快速测试公路10条（263公里），构 建起多区联通、跨区测试网络。推动开展自动驾驶出租车或网 ...

注：如提及个股仅供参考，不代表投资建议。指数/基金短期涨跌幅及历史表现仅供分析参考，不 预示未来表现。市场观点随市场环境变化而变动，不构成任何投资建议或承诺。文中提及指数仅供参 考，不构成任何投资建议，也不构成对基金业绩的预测和保证。如需购买相关基金产品，请选择与风险 等级相匹配的产品。基金有风险，投资需谨慎。 每日经济新闻 （责任编辑：张晓波 ） 【免责声明】本文仅代表作者本人观点，与和讯网无关。和讯网站对文中陈述、观点判断保持中立，不对所包含内容 的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考，并请自行承担全部责任。邮箱： news_center@staff.hexun.com 招商证券指出，生成式AI正在改变计算机和软件开发行业的商业模式，从传统的"基于授权的软件 模式"转变为"按结果收费的服务模式"，AI应用成为劳动替代品，针对服务市场，规模远超传统软件市 场。我国B端软件企业在AIGC领域与海外企业相比仍有差距，主要由于国内企业更倾向"硬件+免费软 件"模式，付费意愿较低。 海外软件巨头在AI应用研发阶段具有先发优势，直接与头部大模型厂商合作，而我国通用大模型 仍处于追赶阶段。制造 ...

Core Insights - The company is experiencing a new wave of growth opportunities in the competitive home appliance market, driven by precise user demand insights and innovative vitality [1] - The capital market has highly recognized the company's strategic transformation, with multiple institutions providing positive ratings and target prices [1][2] Product Innovation - The company launched the ultra-thin 1mm Light Pro Warm Palace Belt in June, addressing user pain points with features like 5-level precise temperature control and antibacterial materials [1] - The split electric stew pot meets the upgraded needs of family kitchens, and promotional strategies have effectively stimulated sales [1] - The company conducts over 20,000 user surveys annually through its "User Direct Plan," leading to rapid growth in its maternal and infant product category, with projected revenue of 250 million yuan in 2024 [1] Strategic Transformation - The company is focusing on high-end flagship products by shrinking low-profit categories and ensuring quality and capacity through smart manufacturing bases and a 2000㎡ testing center [2] - AI technology is applied in the digital field to optimize the supply chain and enhance market response speed through an integrated development system [2] - The company employs a dual-track strategy of "own brand + OEM" for global expansion, increasing R&D investment in Southeast Asia, Japan, South Korea, and Europe while leveraging established channels through OEM/ODM business [2] Financial Performance - The company has seen a decrease in sales expense ratio by 2.55 percentage points year-on-year and an increase in net profit margin by 3.18 percentage points quarter-on-quarter in Q1 2025, indicating improved operational quality [1] - The company is building resilience against challenges like raw material cost pressures through product innovation, efficiency improvements, and strategic focus [2] Market Outlook - The differentiated layout in the health small appliance sector, continuous optimization of the profit model, and steady progress in globalization collectively depict a new landscape for high-quality development [2] - The combination of "User Direct" innovation and refined operational capabilities positions the company for promising growth potential in the market [2]

Core Viewpoint - The Jinan Municipal Government has launched a nine-month special enforcement action under the "Guarding Consumption" initiative to combat illegal activities in the consumer sector [1][3]. Group 1: Enforcement Actions - The enforcement action focuses on key issues such as food adulteration, campus food safety, price violations in the funeral sector, false advertising in elderly care services, and trademark infringement among 18 highlighted problems [3][4]. - A total of 8,856 cases have been investigated, recovering economic losses of approximately 10.2 million yuan for consumers, effectively deterring illegal activities [3]. Group 2: Consumer Complaint Channels - The enforcement team has established multiple complaint channels, including 12345, 12315, and the "Law Enforcement Guardian Card," to encourage public participation in reporting illegal activities [3][4]. - The team has publicly solicited leads on consumer violations, aiming to enhance consumer rights protection through efficient reporting mechanisms [3]. Group 3: Public Awareness and Education - The enforcement team is conducting legal education campaigns in collaboration with industry associations, enterprises, and large supermarkets, utilizing various formats such as consultations, exhibitions, and seminars [4]. - The team has organized 10 "case-based legal education" events, engaging over 4,000 market entities, and regularly publishes typical cases in media to promote lawful and honest business practices [4]. - The strategy includes a combination of strict enforcement, regulation, and education to enhance the effectiveness of law enforcement in the consumer sector [4].

Core Points - A customer at CAVA received a bill for $0 for a falafel pita sandwich priced at $11.05, with the word "love" written on it [1][3] - The cashier informed the customer that they could leave without paying, leading to humorous speculation about the reason behind the gesture [4][5] - CAVA's manager, David Garcia, explained that the restaurant has a "love" button on their cash registers, which allows staff to offer complimentary meals to customers who appear to be in a bad mood, forget their wallets, or are regular patrons [7] - Each CAVA location reportedly uses this "love" button about twice a day [7] - CAVA advises customers not to abuse this feature and emphasizes that it is at the discretion of the staff [8] - Similar acts of kindness are noted in other fast-food chains, such as Chick-fil-A, which sometimes includes handwritten notes in customers' bags during special promotions [8]

Core Viewpoint - Weifang Bincheng Investment Development Co., Ltd. is undergoing a significant ownership change, with its 60% state-owned equity being transferred to the Weifang City Hanting District State-owned Assets Operation Center without compensation [4]. Group 1: Ownership Change - The announcement states that the 180 million yuan (approximately 27 million USD) equity held by Weifang San Nong Innovation Development Group Co., Ltd. will be transferred entirely to the Weifang City Hanting District State-owned Assets Operation Center, resulting in the latter holding 100% of the company [4]. - Prior to this change, Weifang San Nong held 60% of the shares, while the Hanting District State-owned Assets Operation Center held 40% [4]. Group 2: Company Background - Established in August 2005, Bincheng Investment has a registered capital of 3 billion yuan (approximately 450 million USD) and has developed into a large group company covering seven major sectors: finance, urban construction, cultural tourism, agriculture, energy, urban services, and intelligence [9]. - The company currently manages four state-owned enterprises and has over 140 subsidiaries, including one listed company on the Shenzhen A-share market, with total assets amounting to 65 billion yuan (approximately 9.75 billion USD) [9]. Group 3: Legal Issues - Bincheng Investment is involved in a property share transfer dispute, with a court hearing scheduled for June 27, 2025, where the plaintiff is Shandong New Kinetic Energy Fund Management Co., Ltd. [5]. - Recently, *ST Gauss received a notice from its controlling shareholder, Bincheng Investment, regarding a court ruling that mandates the transfer of 39,851,030 shares (23.84% of total shares) to Weifang Guojin Industrial Development Co., Ltd. as compensation for debts, reducing Bincheng Investment's stake from 25.84% to 1.99% [9].

一、证券市场回顾 南财金融终端数据显示，昨日(6月25日,下同)上证综指日内上涨1.04%，收于3455.97点，最高3459.01 点；深证成指日内上涨1.72%，收于10393.72点，最高10403.51点；创业板指日内上涨3.11%，收于 2128.39点，最高2133.03点。 二、ETF市场表现1、股票型ETF整体市场表现 昨日股票型ETF收益率中位数为1.39%。其中按照不同分类，规模指数ETF中华夏创业板50ETF收益率最 高，为4.13%；行业指数ETF中富国中证全指证券公司ETF收益率最高，为5.79%；策略指数ETF中华夏 创业板低波价值ETF收益率最高，为1.97%；风格指数ETF中华夏创业板动量成长ETF收益率最高，为 4.18%；主题指数ETF中华夏中证金融科技主题ETF收益率最高，为7.6%。 3、股票型ETF资金流向 昨日股票型ETF资金流入最多的3只ETF及其流入金额分别为：华泰柏瑞中证A500ETF(流入30.01亿元)、 南方中证1000ETF(流入4.58亿元)、汇添富中证A500ETF(流入4.04亿元)。资金流入前10详情见下表: | 美别 | 代码 | 基金名称 ...

金十数据6月26日讯，据美国有线电视新闻网（CNN）报道，知情人士透露，原定于本周早些时候举行 的美国参议院伊朗局势机密简报会，已重新安排在美东时间周四下午2点（北京时间周五凌晨2点）举 行。特朗普政府近日面临众议院和参议院情报委员会资深民主党人的批评，这些议员对美方空袭伊朗行 动缺乏沟通表示不满。部分议员警告政府不要在简报会前操纵事实。预计众议院将在周五听取简报。 消息人士：美参议院将就伊朗问题举行机密简报会 ...