乐普生物 20250710 摘要 乐普生物的 EGFR ADC（MRG003）针对鼻咽癌适应症预计 2025 年底 至 2026 年初获批上市，头颈鳞癌适应症预计 2027 年内获批。注册性 临床数据在 ASCO 会议上获得积极反馈，商业化策略已在讨论中。 TFADC（MRG004A）靶向组织因子，在胰腺导管腺癌方面显示良好信 号，已完成国内扩组实验，并计划在 ASCO 大会上公布数据。公司已向 中国 CDE 提交注册性临床沟通交流申请，寻求一线治疗方案。 GPC3 ADC（MRG006A）针对肝癌，具有全球首创潜力，目前正在进 行一期临床试验。预计 2026 年分享一期临床数据，并寻求海外合作机 会，肝癌市场潜力巨大。 Claudin 18.2 ADC（CMG901）由乐普生物与康诺亚共同开发，已授 权给阿斯利康，目前处于全球注册性三期临床阶段，预计 2026 年底提 交 NDA 申报。 CDH17 ADC（MRG007）针对结直肠癌，已授权给美国 Biotech Avent，获得国内 IND 批件，即将启动临床试验。总交易金额包括 4,700 万美元首付款及超过 12 亿美元里程碑付款。 Q&A 乐普生物 ...

Core Viewpoint - The article discusses the advancements in fecal microbiota transplantation (FMT) technology, particularly focusing on Chengge Biotechnology's innovative approach to precision microbiota transplantation (PMT) and its recent strategic financing round, which has reignited interest in the microbiome therapy sector. Company Development - Chengge Biotechnology, a pioneer in the field of microbiota transplantation, has recently completed a strategic financing round led by Jinhui Capital, raising over 100 million yuan, which has garnered significant attention for the company that has been operating for nearly a decade [1] - The company has developed a core technology known as "precision microbiota transplantation" (PMT), which enhances the effectiveness of treatment by matching the donor and recipient microbiota based on individual needs, significantly improving treatment success rates [5][6] Market Potential - The global prevalence of gut microbiota imbalance is increasing due to modern lifestyles and antibiotic overuse, leading to a surge in related health issues, including digestive, metabolic, and neurological diseases [1] - The microbiota transplantation industry is still in its infancy, with only about 5% of its potential realized, and the market is estimated to be worth hundreds of billions, indicating substantial growth opportunities [10] Challenges and Strategies - Chengge Biotechnology has faced internal challenges related to early equity structure and external challenges regarding regulatory compliance and market education for its innovative technology [3][7] - The company has established a "Chinese Microbiota Alliance" with 13 microbiota banks across the country to ensure a diverse and localized microbiota pool, which serves as a significant competitive barrier [6] Financial Outlook - The company anticipates sales exceeding 200 million yuan in 2024, with a strong cash flow that supports its research and development initiatives, particularly in the area of live biotherapeutic products [8] Team and Mission - The stability of Chengge's core team is attributed to a shared mission and effective equity compensation, which has attracted talented individuals from various prestigious backgrounds [11]

Group 1 - The core event is the announcement of 4 top talents and 15 major innovation teams in Suzhou during the 2025 Higher Education Technology Transfer Conference and the 17th International Elite Entrepreneurship Week [1] - Suzhou's top talent program has attracted 10 academicians and a total of 25 full-time academicians from home and abroad over the past year [1] - The major innovation teams focus on "bottleneck" technologies, with 6 projects in artificial intelligence, 3 in integrated circuits, 2 in biomedicine, 2 in advanced materials, and 2 in photonics, all of which are expected to drive high-end industrial development [1] Group 2 - Among the 15 major innovation teams, 8 are led by overseas returnees, with many members having experience in leading domestic and international companies [2] - Teams recognized as major innovation teams can receive project funding of up to 30 million yuan, and team leaders and core members can receive housing subsidies of up to 2 million yuan [2] - The recognition of the team from Renmin University of China highlights Suzhou's commitment to fostering innovation in artificial intelligence and smart governance, aiming to enhance collaboration between academia and industry [2]

Group 1 - The core viewpoint emphasizes that not all investors need to chase market hotspots, as investment styles vary, with value investors focusing on company growth and reasonable pricing rather than market trends [1][2] - Investors should first assess their current stocks to determine if they are in an acceptable fluctuation or a declining trend, adopting a "day one" mindset to evaluate their willingness to buy the stock if they didn't already own it [2][3] - If investors decide to switch stocks, it should be done gradually and during market corrections rather than during strong rallies to mitigate risks [2][3] Group 2 - Recognizing market hotspots requires a certain level of experience and understanding, as investors need to justify their choices and timing for entering or exiting positions [3] - The decision to switch stocks should be based on a solid investment philosophy, with a focus on whether the investor genuinely believes in the selected investment strategy rather than impulsively jumping between different sectors [3]

Group 1 - The 2025 Suzhou Key Technology Global "Challenge" List was released, featuring 45 key technology demands with a total investment of 5.412 billion yuan, covering sectors such as new energy, new generation information technology, biomedicine and health, high-end equipment, advanced materials, and emerging digital industries [1][2] - The list includes demands from all industrial clusters in Suzhou's "1030" development plan, focusing on technology upgrades for enterprises, cutting-edge research by institutions, and policy-driven domestic and green innovation [1][2] - The highest single demand has an investment of 250 million yuan, with 23 demands exceeding 100 million yuan [1] Group 2 - The initiative aims to gather global innovation resources to collaboratively tackle key core technologies, inviting universities, research institutes, and innovative enterprises to participate [2] - Successful projects will be included in Suzhou's global key core technology "Challenge" program, receiving up to 10 million yuan in support, which is 50% of the challenge amount [2] - A total of 40 projects were announced during the event, including 15 regional cooperation projects, 15 university-enterprise joint projects, and 10 major technology investment projects [2]

今 年 ， 港 股 融 资 市 场 极 为 火 热 。 Wind 数 据 显 示 ， 今 年 以 来 ， 港 股 市 场 股 权 融 资 规 模 已 逼 近 3000 亿 港 元 ， 达 到 2879.82 亿 港 元 ， 同 比 大 增 350.56%。 总体来看，今年港股市场无论是IPO还是再融资规模都呈爆发式增长，尤其是IPO表现更为抢眼。港股上半年共完成42宗IPO，合计集资额超过1070亿港元，较去年 全年多约22%，暂列全球第一。 融资规模持续创新高 在2023年和2024年，港股市场无论是IPO还是再融资都较为疲软，IPO方面这两年分别融资463.34亿港元和881.47亿港元，均不超过千亿港元；再融资方面，主要 以配售为主，这两年分别融资661.61亿港元和545.99亿港元，同样不超过千亿港元。 但自2024年下半年以来，港股市场在多项重磅政策带动下再次活跃，而在2025年上半年，整个市场更是不断复苏。 Wind数据显示，2025年以来，港股市场股权融资规模已达到2879.82亿港元，远高于2023年和2024年全年的1424.39亿港元和1756.60亿港元，甚至也已经高于 2022年全年 ...

Group 1 - The core viewpoint of the articles highlights the advancements and innovations in the pharmaceutical and manufacturing sectors in Hanzhong, particularly focusing on Hanjing Pharmaceutical and Guda CNC (Hanzhong) Co., Ltd [1][2][3] - Hanjing Pharmaceutical, established in 1970, specializes in the research, production, and sales of chemical raw materials, intermediates, and pharmaceutical preparations, providing high-quality and affordable medicines to a wide market [1] - The company has developed modern production facilities equipped with self-developed drug reaction furnaces and waste treatment systems, ensuring high purity and compliance with environmental standards [1] - Hanjing Pharmaceutical has established four high-end production workshops and has a significant market presence both domestically and internationally, exporting to over 100 countries and regions [1] Group 2 - Continuous investment in research and development has been a key factor in Hanjing Pharmaceutical's achievements, with the establishment of provincial academician and expert workstations leading to significant scientific advancements [2] - Guda CNC (Hanzhong) Co., Ltd. has rapidly developed its production capabilities, launching a new assembly line for CNC machine tools within three months, with an annual R&D investment of 30 million yuan [2] - The company produces 16 types of high-end intelligent equipment, achieving breakthroughs in core components and control systems, thus enhancing the competitiveness of the domestic manufacturing sector [2][3] - The introduction of advanced CNC technology allows for significant efficiency improvements, with one CNC machine completing the work of four traditional machines in a fraction of the time [3]

来源：安徽日报 记者7月10日从中国科学技术大学获悉，该校教授毕国强、刘北明联合合肥综合性国家科学中心人工智 能研究院和中国科学院深圳先进技术研究院团队，突破性研发出全球最快的小动物全身亚细胞分辨率三 维成像技术，首次实现小鼠全身神经网络精细三维图谱高清绘制，为解析周围神经调控网络及疾病机理 研究提供了全新工具。相关成果于当日发表于国际学术期刊《细胞》。 记者：陈婉婉 导师与团队成员讨论。周欣宇 摄 "眼见为实，我们可以不依赖间接证据，直接'看见'全身神经网络如何精密连接、如何与不同组织器官 互作。"毕国强表示。这项突破性技术将有望帮助回答生命医学领域中悬而未决的关键问题，为未来精 准外周神经调控治疗等医学新技术的开发提供底层结构数据基础。"例如，通过全面且精准定位如阿尔 茨海默症这一类神经退行性疾病的早期结构变异，来明确疾病的致病机理；以可视化方式评估药物对全 身组织和器官的靶向效果，加速药物研发进程。"毕国强说。 据介绍，团队将持续公开研究成果图像数据集，实现资源全球共享，以推动生物医药交叉合作。 研究团队合影（从左到右：张轲铭、徐程、祝清源、毕国强、刘北明、时美玉、姚雨辰、王淼）。周欣 宇 摄 在生物体 ...

Core Viewpoint - Gannee Pharmaceutical (甘李药业) is experiencing significant growth in its performance, with a projected net profit increase of 100.73% to 114.12% for the first half of 2025, driven by market share expansion through insulin procurement initiatives [1][3]. Group 1: Financial Performance - For the first half of 2025, Gannee Pharmaceutical expects a net profit of 6 billion to 6.4 billion CNY, and a non-net profit of 4.6 billion to 5 billion CNY, reflecting year-on-year increases of 100.73% to 114.12% and 262.47% to 293.99% respectively [1][3]. - In Q1 2025, the company reported revenues and net profits of 9.85 billion CNY and 3.12 billion CNY, showing year-on-year growth of 75.76% and 224.9% [3]. - The second quarter of 2025 is estimated to yield a net profit between 2.88 billion and 3.28 billion CNY, indicating a year-on-year growth of 41.87% to 61.58% [3]. Group 2: Market Strategy - Gannee Pharmaceutical has successfully expanded its market share through two rounds of insulin procurement, achieving a 32.6% increase in procurement volume for 2024 compared to the previous round, leading to a synergistic effect of volume and price recovery [3]. - The company has a comprehensive insulin research and development pipeline, covering long-acting, rapid-acting, and premixed insulin products, positioning it as a leading player in the domestic market [2]. Group 3: Share Buyback and Dividends - As of June 30, 2025, Gannee Pharmaceutical has repurchased shares worth approximately 1.5 billion CNY, reaching the lower limit of its buyback plan, which aims to repurchase between 1.5 billion and 3 billion CNY [4]. - Since its listing in 2020, the company has conducted six dividend distributions, totaling 16.12 billion CNY, with a dividend payout ratio of 34.45% [4].

登录新浪财经APP 搜索【信披】查看更多考评等级 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗漏，并对其内容 的真实性、准确性和完整性依法承担法律责任。 重要内容提示： ● 本次股票上市类型为股权激励股份；股票认购方式为网下，上市股数为1,615,000股。本公司确认，上 市流通数量（空）该限售期的全部战略配售股份数量。 本次股票上市流通总数为1,615,000股。 ● 本次股票上市流通日期为2025年7月16日。 根据中国证券监督管理委员会、上海证券交易所、中国证券登记结算有限责任公司上海分公司有关业务 规则的规定，科兴生物制药股份有限公司(以下简称"公司")于近日收到中国证券登记结算有限责任公司 上海分公司出具的《证券变更登记证明》，公司已完成2024年限制性股票激励计划（以下简称"本激励 计划"）第一个归属期归属（以下简称"本次归属"）的股份登记工作。现将有关情况公告如下： 一、本次限制性股票归属的决策程序及相关信息披露 1、2024年5月24日，公司召开第二届董事会第十五次会议，审议通过了《关于公司〈2024年限制性股票 激励计划（草案）〉及其摘要的议案》《关于公司〈2 ...