撰文丨王聪 编辑丨王多鱼 排版丨水成文 通过构建一组肺癌患者队列，研究团队证明了在抗 PD-1 （αPD1） 治疗下 GLI 模型的响应能够精确反映相 应患者的免疫治疗结果。 此外，研究团队通过功能多组学分析， 在 GLI 模型中剖析了由外周血单个核细胞 （PBMC） 来源的 T 细胞 介导的各种肿瘤免疫过程，并对具有效应记忆样表型 （GNLY + CD44 + CD9 + ） 的循环肿瘤反应性 T 细胞 进行了表征，将其作为免疫治疗效果的潜在指标。 破译 肿瘤微环境 和 系统免疫宏观环境 之间的相互作用，对于开发更有效的癌症诊断和治疗策略至关重要。 2025 年 6 月 12 日，清华大学生物医学工程学院 刘鹏 副教授、 北京航空航天 大学生物与医学工程学院 陈晓芳 副教授、 北京大学人民医院 杨帆 教授团队合作，在 Cell 子刊 Cell Stem Cell 上发表了题为 ： An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer 的研究论文。 该研究开发了一种 类器官共培养模型—— 凝胶- ...

Core Insights - Standard BioTools Inc. has launched its inaugural Proteomics Roundtable Series to discuss advancements in the field of proteomics and its implications for healthcare [1] - The first session will focus on high-plex, high-quality proteomics, featuring insights from researchers involved in the EPIC cancer study [2] - Future sessions will cover various topics, including comparative metrics for proteomic platforms, deployment in biobanks, and the role of proteomics in accelerating drug development [3][4][5] Company Overview - Standard BioTools Inc. is a leading provider of next-generation technologies aimed at enhancing biomedical research and drug development [7] - The company utilizes proprietary technologies such as SomaScan, mass cytometry, and microfluidics to provide reliable insights into health and disease [7] - Standard BioTools collaborates with academic, government, and clinical laboratories globally, focusing on critical areas in translational and clinical research [9]

Core Viewpoint - The article discusses a breakthrough in reconstructive surgery for ear deformities, utilizing bacteria as a "biological 3D printer" to create customizable artificial ear scaffolds, potentially transforming clinical practices in auricular reconstruction [2][4]. Group 1: Challenges in Traditional Methods - Traditional ear reconstruction methods involve harvesting rib cartilage, which presents three main challenges: insufficient rib cartilage in children requiring multiple surgeries, the complexity of sculpting and stitching that relies heavily on the surgeon's skill, and the risk of postoperative complications such as infections and scaffold exposure [4][5]. - Existing artificial materials used as cartilage substitutes also face issues, including manual shaping and stitching, along with the risk of rejection [4]. Group 2: Innovative Approach - The research team focused on the bacterium Komagataeibacter xylinus, which can synthesize bacterial cellulose known for its high purity, nanoscale network structure, excellent biocompatibility, and functionalization properties [4][5]. - The bacteria exhibit an "oxygen navigation" feature, allowing them to gather in oxygen-rich areas and secrete nanofibers, which are utilized to create the ear scaffold [5]. Group 3: Key Innovations in Scaffold Production - The team designed a high-oxygen-permeable silicone mold to achieve three critical controls: precise molds created from 3D-printed ear models, dynamic oxygen supply to guide bacteria evenly throughout the scaffold, and nanometer-level precision in the cellulose fibers produced [5][7]. - The cellulose fibers have a diameter of 20-100 nanometers and form a cartilage-like network structure with mechanical strength comparable to real ear cartilage, with an elastic modulus ranging from 3.89 to 9.56 MPa [5][8]. Group 4: Performance and Clinical Implications - After 21 days of bacterial "biomanufacturing" and purification, the artificial ear scaffolds demonstrated remarkable characteristics: precise replication of ear structures, high tensile strength with no deformation after 50 days of immersion, long-term stability in the body, and extremely low endotoxin levels [8][9]. - The scaffolds show over 95% survival rates for cartilage and skin cells, allowing for rapid integration with surrounding tissues, indicating significant clinical application potential for personalized ear reconstruction [9]. Group 5: Broader Impact - This research marks the first application of microbial manufacturing technology in organ reconstruction, offering hope for patients with ear deformities and paving the way for future developments in complex tissue engineering, potentially extending to heart valves and vascular networks [9].

Core Insights - The Leukemia & Lymphoma Society (LLS) has partnered with Kroger's Dallas Division to raise funds for The Dare to Dream Project, aimed at improving treatments for pediatric blood cancer patients and providing support for their families [1][2][4] Group 1: The Dare to Dream Project - The Dare to Dream Project is a $175 million campaign focused on funding pediatric blood cancer research, advocating for healthcare policy changes, and expanding support services for affected children and families [8] - Only 5% of cancer drugs have been approved for first-time use in children, and 80% of childhood cancer survivors face chronic health issues due to their treatments [3] Group 2: Fundraising Efforts - From May 14 to June 3, 2025, Kroger encourages customers to donate at checkout in 110 stores across North and East Texas and Louisiana to support LLS's Dare to Dream Project [2] - Funds raised will exclusively benefit the life-saving work of The Dare to Dream Project, helping to ensure better treatment outcomes for children with blood cancer [1][2] Group 3: LLS's Commitment - LLS is pioneering pediatric blood cancer research, including the establishment of the first-ever pediatric AML Data Commons and the launch of the LLS PedAL Master Clinical Trial [4] - The organization has been dedicated to improving the quality of life for blood cancer patients and their families for over 75 years [6]

IQVIA Holdings Inc. (IQV) will release its first-quarter 2025 results on May 6, before market open.IQV has a decent earnings surprise history, having surpassed the Zacks Consensus Estimate in the trailing four quarters, the average surprise being 1.7%.IQVIA Holdings Inc. Price, Consensus and EPS Surprise IQVIA’s Q1 ExpectationsThe Zacks Consensus Estimate for revenues is pegged at $3.8 billion, increasing marginally on a year-over-year basis.Research and Development Solutions (R&DS) revenues are expected to ...

Nautilus Biotechnology (NAUT) Q1 2025 Earnings Call April 29, 2025 08:30 AM ET Company Participants Ji-Yon Yi - Vice PresidentSujal Patel - Co-Founder, CEO & DirectorParag Mallick - Co-Founder, Chief Scientist & DirectorAnna Mowry - Chief Financial OfficerElizabeth Koslosky - Global Investment Research AssociateThomas VonDerVellen - Equity Research Associate Conference Call Participants Jason Lai - Analyst Operator Good day, and thank you for standing by. Welcome to the Nautilus First Quarter twenty twenty ...

Nautilus Biotechnology (NAUT) Q1 2025 Earnings Call April 29, 2025 08:30 AM ET Company Participants Ji-Yon Yi - Vice PresidentSujal Patel - Co-Founder, CEO & DirectorParag Mallick - Co-Founder, Chief Scientist & DirectorAnna Mowry - Chief Financial OfficerElizabeth Koslosky - Global Investment Research AssociateThomas VonDerVellen - Equity Research Associate Conference Call Participants Jason Lai - Analyst Operator Good day, and thank you for standing by. Welcome to the Nautilus First Quarter twenty twenty ...

有很多习惯，我们知道它对健康不利，但总会"不自觉"地放纵自己，比如熬夜、吃高热量的垃圾食品等等—— 但其实，这些坏习惯对我们健康的危害比想象中更严重。 首先，《Nature》子刊的一篇研究论文表明，一系列环境因素，包括生活方式 （例如吸烟、运动锻炼） 和生活条 件，对健康和衰老的影响比遗传因素的影响更大。 其次，睡眠作为人体最基本的生理需求之一，其质量的高低直接关系到免疫系统的功能和整体健康状态。一项 发表在《The Journal of Immunology》的研究指出，即使是短暂的一夜不睡，也会对免疫系统产生显著的负面影 响，使单核细胞的特征发生改变，进而引发慢性炎症和相关疾病的风险增加。 最后，饮食习惯对健康的影响也不容小觑。另一项发表在《Nature》子刊的研究显示，即使是短期的高热量饮 食，也会对大脑结构和功能产生长期的不良影响。 这些研究为我们提供了关于生活习惯对健康影响的有力证据，同时，它们不仅为我们敲响了警钟，也为改善健 康提供了新的方向。 生活方式的影响，远超基因 虽然人类的人均寿命已经突破了80岁，但是我们关于衰老的认知仍然在被不断颠覆——2025年2月19日，牛 津大学的研究人员在国际顶 ...

作 者丨闫硕 程迪 黄兰雯 白宇航 陈珊 编 辑丨季媛媛 林青云 3月2 9日，由中国癌症基金会、北京乳腺病防治学会、琼海博鳌肿瘤创新研究院联合主办，国 家癌症中心、中国医学科学院肿瘤医院承办的2 0 2 5肿瘤健康管理大会暨健康中国癌症防治首 席专家论坛在京召开。会上同步开展肿瘤患者生育力保护联盟暨早发乳腺癌防治与生育健康工 程启动仪式。 肿瘤患者生育力保护联盟汇聚肿瘤科、生殖科、心理科等跨学科顶尖专家，联动医疗、科研、 公益及媒体等多方力量，旨在为肿瘤患者提供全生命周期生育力保护支持，探索具有中国特色 的恶性肿瘤防治方案。 作为联盟的核心行动， "早发乳腺癌防治与生育健康工程"也在会上同步启航。 这项工程将聚 焦学术、公众、患者三方协同，未来将持续开展相关学术和公益活动，依托肿瘤患者生育力保 护联盟、媒体机构和患者组织构建科普防治网，以乳腺癌作为首个试点癌种，未来针对整体年 轻肿瘤患者，推动形成癌症早诊早筛和生育力保护重要性的科普宣传和全社会共同参与的社会 性支持性网络。 肿瘤患者生育力保护联盟暨早发乳腺癌防治与生育健康工程正式启动 肿瘤患者生育力保护联盟成立 共建生育力保护平台 国家癌症中心数据显示，2 ...