Advancing Care for Underserved Neurological and Rare Diseases R&D Day • New York City June 25, 2025 © 2025 Acadia Pharmaceuticals Inc. All rights reserved. Catherine Owen Adams CEO Opening Remarks Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements other than statements of historical fact and can be identified by terms such as "may," "will," "should," "co ...

Investor Presentation May 2025 Forward-Looking Statements This presentation contains certain statements that are, or may be deemed to be, forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may include, but are not limited to, discussions of Reliance's industry and end markets, business strategies, acquisitions, and expectations concerning the Company's future growth and profitability and its ability to generate industry leading r ...

Core Viewpoint - Beeline Holdings, Inc. is pioneering a title platform for lenders that utilizes stable coins to enhance liquidity in residential real estate transactions, marking a significant advancement in blockchain-driven real estate finance [1][4]. Group 1: Company Developments - Beeline Title has successfully closed a residential real estate transaction funded through a cryptocurrency token backed by real property, indicating a major milestone in integrating decentralized finance with traditional title services [1]. - The company plans to launch a Fractional Sale of equity product leveraging the crypto ecosystem in August 2025, with Beeline Title providing title and closing services for these transactions [2]. - Beeline Title aims to open its platform to all mortgage lenders, offering a solution for cryptocurrency token transaction reconciliation, compliance, and disbursement [3]. Group 2: Leadership and Expertise - Nick Liuzza, CEO of Beeline Holdings, emphasizes the need for a title company that understands blockchain transactions and has the necessary infrastructure to comply with regulations for these models to function at scale [2]. - The team behind Beeline Title previously built Linear Title, one of the largest privately held title agencies in the U.S., closing over one million title transactions across all 50 states through 2019, showcasing their extensive experience in the field [4]. Group 3: Industry Positioning - As cryptocurrency adoption increases and becomes regulated, Beeline is positioning itself as a leader in the evolving ecosystem, providing trusted infrastructure to help lenders integrate crypto with compliance [4]. - Beeline Financial Holdings, Inc. is transforming property financing through its digital, AI-powered platform, aiming to streamline the mortgage origination process with speed and transparency [5].

Core Insights - Silo Pharma has entered into a non-binding letter of intent to form a 50:50 joint venture with Hoth Therapeutics to develop a treatment for obesity and metabolic diseases based on technology licensed from the U.S. Department of Veterans Affairs [1][3] - The joint venture aims to leverage a novel therapeutic platform centered on glial cell line-derived neurotrophic factor (GDNF), which has shown anti-obesity effects in preclinical models [2][4] - The obesity market is valued at approximately $16 billion, with the potential for significant impact on veterans and civilians suffering from metabolic disorders [3][4] Unmet Need - Over 40% of U.S. adults are affected by obesity, which is a leading risk factor for various health issues, including diabetes and cardiovascular disease [4] - Veterans face unique challenges related to obesity, including chronic inflammation and PTSD-related metabolic disruptions, highlighting the need for effective treatments [4] Strategic Alignment - The partnership will utilize the exclusive U.S. license from the Department of Veterans Affairs, ensuring comprehensive coverage for all fields of use [7] - The joint venture structure allows for equal equity and governance participation between Silo Pharma and Hoth Therapeutics [7] - The collaboration combines the clinical infrastructure of the VA, Hoth's regulatory expertise, and Silo's translational capabilities [8]

每经记者｜兰素英 郑雨航 每经编辑｜易启江 王嘉琦 对于普通登山运动员来说，攀登珠峰顶通常要用40~45天。需要长时间的高海拔拉练和在冰川营地间往返训练，让身体先适应六七千米的海拔高度。 最近，有人靠着价值124万元的氙气"外挂"，仅用了4天18小时，就成功登上珠峰顶，创造了新的纪录。此举在登山界掀起了轩然大波，不仅没有获得满堂 彩，反而成为众多登山爱好者和从业者强烈抨击的对象。 借助氙气疗法征服珠峰，到底是登山精神的消亡，还是科技进化的必然？参加氙气疗法究竟是什么体验？背后还有哪些争议？《每日经济新闻》记者（简 称每经记者）找到了当事人，力求真实还原这一事件。 1 4天18小时的"不可能任务" 英国老兵如何"闪登"珠峰？ 当资深登山者陈涛（业界人称"强子"）带领他的队伍从海拔8848.86米的珠穆朗玛峰顶安全撤下后两天，5月21日上午7点10分，一支英国登山队也站上了 世界之巅。 他们于5月16日从海拔仅24米的伦敦希思罗机场启程，到世界之巅，全程耗时约4天18小时。这一速度，刷新了人们对于珠峰攀登周期的固有认知，也让在 大本营通过直播屏幕目睹这一幕的强子脱口而出两个字："震撼！" 这趟注定载入珠峰攀登史册 ...

凤凰网科技讯（作者/于雷）6月25日，vivo今日正式发布X Fold5折叠屏手机，该产品在电池技术、防护 能力和跨生态连接方面实现多项技术突破。新机搭载等效6000mAh蓝海电池，支持全球首发三防折叠屏 设计，并首次实现安卓设备与Apple Watch的连接功能，起售价6999元，将于7月2日正式开售。 影像系统配置了5000万像素蔡司超级长焦镜头，搭载索尼IMX882传感器，支持蔡司长焦人像、长焦风 光、长焦微距等多种拍摄模式。同时提供蔡司全焦段人像、AI天气变装、经典负片风格等功能。 跨生态连接成为X Fold5的突出亮点。该设备首次实现安卓手机连接Apple Watch，用户可通过手表接听 来电、查看信息，并同步健康数据至vivo健康应用。此外还支持AirPods无缝连接体验，可在文件管理 中直接访问Mac设备，支持跨应用拖拽文件传输，并可作为Mac的扩展屏使用。 在多任务处理能力上，支持原子工作台功能，可实现最多五个应用并行运行。 vivo X Fold5在电池技术、防护标准和跨生态互联方面的突破，展现了折叠屏设备向实用化方向发展的 趋势。 在设计工艺上，X Fold5整机重量控制在217g，轻于多 ...

新京报讯（记者左琳 通讯员马振涛 周玉辉）2025年北京中考在6月24日至25日举行，正值持续高温天 气，为全力保障中考期间车辆安全稳定运行，确保广大考生顺利赴考，北京公交集团保修分公司严格贯 彻落实集团公司工作部署，周密部署、精准施策，全面开展中考期间车辆技术服务保障工作，并同步推 进暑期汛期车辆安全风险隐患排查治理。 据悉，保修分公司紧扣中考保障核心任务，主动对接运营实际需求，系统梳理途经考点周边区域重点线 路车辆信息。 针对本周持续高温天气，保修分公司迅速组建专业"车医生"团队，制定并细化中考期间高温天气车辆安 全管控方案，以电驱动、燃气及高役龄车辆为重点保障对象，对易受高温影响、灰尘易积存的关键部 位，开展全面细致的检查与清洁作业，同时加强对车辆冷却液效能的专业检测评估，多措并举提升车辆 通风散热性能，从源头上消除高温引发的车辆安全隐患。 在落实高温防范措施方面，保修分公司紧密结合"安全生产月"活动，组织全员开展暑期安全防范知识再 教育，深入学习防暑降温措施及岗位安全职责，强化全员安全责任意识，通过开展安全生产综合检查、 调位互查、专项稽查等多种形式，持续深化安全生产隐患排查治理，重点监督消防安全、行 ...

齐鲁晚报.齐鲁壹点于泊升 施工期间，各项目团队充分抢抓施工黄金期，高效完成桩基施工、土方开挖清运、钢筋安装及混凝土浇 筑工作，顺利完成建设目标任务，下一步将进行钢结构屋盖及建筑屋面安装施工。 项目建成后，将系统完善片区交通、餐饮、住宿等城市功能配套，加速人口与资源集聚，培育"体育 +文旅"融合消费新场景，推动体育产业全链条升级，通过承接国际赛事、品牌展演与投资活动，持续 转化赛事流量为消费增量、提升城市竞争力，以赛事经济撬动城市发展新动能，赋能区域产业升级与城 市能级跃升。 济南起步区黄河体育及科技园区基础设施一期工程游泳馆及全民健身中心施工项目设计为甲级体育建 筑，总建筑面积为16.63万平方米，总座席数约4000座，地上部分为游泳跳水馆和全民健身中心。 济南起步区黄河体育及科技园区基础设施一期工程体育馆建筑面积约10.9万平方米，高41.8米，含1.8万 个观众座席，项目定位篮球、冰球、电子竞技三位一体顶级竞赛中心，集多功能于一体的综合比赛场 地，建筑外立面采用国内首例动态变色三角百叶幕墙，项目建成后可承接国内高水平冰上项目赛事，同 时可满足大型文化活动、中小型会展、日常开放及培训。 近日，由济南城市建设 ...

药捷安康是一家以临床需求为导向、处于注册性临床阶段的生物制药公司,专注于发现及开发肿瘤、炎 症及心脏代谢疾病小分子创新疗法。凭借本身全面融合的内部"ACE"方法,公司已建立六款临床阶段候 选产品及一款临床前阶段候选产品的管线,并计划持续拓展。公司专注于开发具有重大临床价值的同类 首创或同类最佳候选药物,以满足全球未被满足的临床需求。其核心产品Tinengotinib(TT-00420)是一款 处 于 注 册 性 临 床 阶 段 、 自 主 研 发 的 独 特 多 靶 点 激 酶 ("MTK") 抑 制 剂 ( 主 要 靶 向 三 个 关 键 通 路:FGFR/VEGFR、JAK和Aurora激酶)。截至目前,Tinengotinib正在进行两项关键性/注册性临床试验,用 于治疗在过往接受FGFR抑制剂治疗后疾病发生进展的胆管癌("CCA")患者,分别在中国和国际多中心临 床试验("MRCT")进行。 2025年6月23日,创投集团合作子基金南京紫金先进制造产业股权投资中心(有限合伙)(以下简称"紫金先 进制造基金")投资企业——药捷安康(南京)科技股份有限公司(以下简称"药捷安康") 正式于香港联合交 易所有 ...

Improving health and quality of life with advanced robotics designed to enhance, amplify, and restore human function. Investor Presentation January 13, 2025 Disclaimer This presentation contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Any statements contained in this presentation that do not describe historical facts may constitute forward-looking statements. Forward-looking ...