TELA Bio (TELA) 2025 Conference June 05, 2025 11:05 AM ET Speaker0 All right. We can kick this off. Hello, everyone. My name is Mike Sarcone. I'm an analyst on the US Medical Supplies and Devices team. And this is day two of the Jefferies twenty twenty five New York Health Care Conference. This is a fireside chat with TeleBio. And from the company, we have Tony Koblish, founder, president, and CEO and Roberto Kuka, chief operating officer and CFO. Gentlemen, thank you for joining us today. Speaker1 Thank yo ...

Stevanato Group (STVN) 2025 Conference June 05, 2025 10:30 AM ET Speaker0 Jeff there we go. Hi. Good morning. Dave Windley with Jefferies Healthcare Equity Research. Appreciate your attendance and and interest in our conference twenty twenty five. We are on kind of the homestretch here on Thursday. Our presenting company for this session is Stevanato Group. Here to present for them is the company's CEO, Franco Sveinato. So he has just a few slides and is going to give some prepared remarks to kick off and t ...

Core Insights - Inspira Technologies is scaling up production capabilities for its FDA-cleared INSPIRA™ ART100 system in response to anticipated demand from a European governmental authority, with advanced-stage procurement negotiations underway [1][2][3] - The ART100 system is already in clinical use in the U.S. and is recognized as a reliable device for critical care and emergency preparedness [2][3] - The company aims to fast-track revenue generation from the ART100 system while continuing to develop next-generation platforms, including the ART500 and HYLA™ blood sensor [3][4] Company Overview - Inspira Technologies specializes in advanced respiratory support and real-time blood monitoring solutions, with the ART100 system approved for cardiopulmonary bypass in the U.S. and ECMO procedures outside the U.S. [5] - The ART500 is a next-generation system designed to provide oxygenation while patients remain awake and spontaneously breathing, and the HYLA™ platform offers continuous, non-invasive blood monitoring [5] - The company is positioned as an attractive platform within the critical care and MedTech landscape, reflecting broader industry trends such as consolidation and cross-sector collaboration [5]

Core Insights - Intuitive Surgical's da Vinci 5 (dV5) system is gaining traction, with 147 units placed and over 32,000 procedures performed in Q1 2025, indicating strong customer response [1][8] - The innovative Force Feedback technology is showing clinical potential by enhancing surgical precision and improving post-operative recovery times [2][8] - Additional upgrades, including real-time 3D model review and integrated simulation software, are expected to launch mid-year, enhancing procedural insight and surgeon performance [3][4] Company Developments - Intuitive Surgical is aligning its innovations with surgeon training needs and operational efficiency, positioning dV5 as a cornerstone for future growth [4] - The company is scaling its supply chain to support a broader launch of the dV5 system, with expectations for steady growth in the adoption of force feedback instruments through 2025 [3][4] Competitive Landscape - Stryker introduced its fourth-generation Mako SmartRobotics system, enhancing surgical planning and execution capabilities across various procedures [5] - Globus Medical showcased its ExcelsiusFlex robotic navigation system, designed to enhance surgical precision and accommodate diverse patient needs [6] Financial Performance - Intuitive Surgical's shares have gained 0.2% year-to-date, contrasting with a 4.3% decline in the industry [7] - The company trades at a forward price-to-earnings ratio of 36.05, above the industry average but lower than its five-year median of 52.54 [9] - The Zacks Consensus Estimate for Intuitive Surgical's 2025 earnings suggests a 2.8% increase from the previous year [10]

Butterfly Network (BFLY) FY Conference Summary Company Overview - Butterfly Network is focused on revolutionizing medical imaging, particularly ultrasound technology, by making it more accessible and cost-effective through semiconductor innovations [8][9][21] Industry Insights - The ultrasound market is projected to grow significantly, with the core point-of-care ultrasound market estimated at $600 million and the broader market potentially reaching $8 billion [50] - There is a notable lack of access to medical imaging globally, with two-thirds of the world lacking access to ultrasound [7] Key Financials - The company projects a 20% growth for the year, targeting revenues between $96 million and $100 million, with an EBITDA loss [8] - The first quarter of 2025 saw a revenue of $25 million, reflecting the anticipated growth trajectory [8] Technological Innovations - Butterfly Network utilizes MEMS semiconductor technology, allowing for a compact, cost-effective ultrasound device that can be used by various healthcare professionals [19][21] - The company has launched its third generation of ultrasound devices, with plans for a fourth generation expected by 2026 [39][41] - The device's capabilities are enhanced through a cloud-based software ecosystem, which allows for continuous updates and improvements [25][26] AI Integration - Butterfly has developed AI tools that assist in ultrasound scanning, including automatic bladder volume measurement and lung assessments for congestive heart failure [33] - The company is opening its ecosystem to third-party developers, allowing for the creation of additional AI applications that can be integrated with Butterfly devices [34] Market Position and Strategy - Butterfly Network claims the largest installed base for handheld ultrasound devices, surpassing competitors like GE and Philips [36] - The company is actively pursuing partnerships and licensing opportunities for its semiconductor technology, expanding its market reach beyond healthcare [62][63] Educational Initiatives - Approximately 70% of medical schools in the U.S. are incorporating Butterfly devices into their training programs, fostering a new generation of healthcare professionals skilled in ultrasound [55][56] - The company is developing educational tools to assist students in learning ultrasound techniques, enhancing their practical skills [58][59] Future Outlook - Butterfly Network aims to expand its presence in home healthcare by training nurses to perform ultrasound scans, potentially creating new revenue streams [61] - The company is committed to leveraging its $300 million investment in semiconductor technology to explore opportunities in various sectors, including wearables and non-healthcare applications [63] Conclusion - Butterfly Network is positioned as a disruptive force in the ultrasound market, with a strong focus on innovation, accessibility, and education, aiming to transform how ultrasound technology is utilized in healthcare and beyond [49][50]

Core Insights - Exact Sciences Corporation (EXAS) is focused on promoting its flagship product, Cologuard, as the standard of care in cancer screening, aiming to transform cancer care through innovative solutions [2][4] - The company has shown a strong stock performance with a 23.5% increase over the past year, outperforming the industry and S&P 500 [3] - Despite a solid market capitalization of $10.34 billion and a long-term earnings growth rate of 29.3%, EXAS faces challenges related to solvency and rising operational costs due to macroeconomic pressures [3][14] Company Performance - Cologuard has been utilized in 16 million tests over the past decade, with a 14% increase in screening revenues in Q1 2025, driven by growth in rescreens and new provider adoption [4][9] - The international adoption of Oncotype DX contributed to a 4% year-over-year growth in Precision Oncology revenues, indicating significant growth potential in markets outside the U.S. [5] - The company is enhancing customer experience by building a robust digital infrastructure that empowers patients and simplifies the ordering process for physicians [6] Strategic Initiatives - The launch of Cologuard Plus, which is expected to reduce unnecessary follow-up colonoscopies by up to 40%, marks a significant advancement in non-invasive CRC screening [11] - The Oncodetect MRD test is anticipated to receive Medicare reimbursement in Q2 2025, further expanding EXAS's diagnostic offerings [12] - The company has identified over 100 opportunities with payers and health systems to address care gaps through organized screening programs [10] Financial Overview - As of Q1 2025, EXAS reported cash and cash equivalents of $786 million, but it also carries a long-term debt of $2.32 billion, raising concerns about its financial leverage [13] - The Zacks Consensus Estimate for EXAS's loss in 2025 has improved from 61 cents to 14 cents, with projected revenues of $3.10 billion, reflecting a 12.4% year-over-year increase [15]

Core Insights - Inspira Technologies has scaled up production capabilities for its FDA-cleared INSPIRA ART100 system in anticipation of demand from a European governmental authority, with advanced-stage procurement negotiations ongoing [1][2][3] - The ART100 system is already in clinical use in the U.S. and is recognized as a reliable device for critical care and emergency preparedness [2][3] - The company aims to fast-track revenue generation from the ART100 system while continuing to develop next-generation platforms, including the ART500 and HYLA blood sensor [3][4] Company Overview - Inspira Technologies specializes in advanced respiratory support and real-time blood monitoring solutions, with the ART100 system approved for cardiopulmonary bypass in the U.S. and ECMO procedures outside the U.S. [5] - The ART500 is a next-generation system designed to provide oxygenation while patients remain awake and spontaneously breathing, and the HYLA platform offers continuous, non-invasive blood monitoring [5] - The company is positioned as an attractive platform within the critical care and MedTech landscape, reflecting broader industry trends such as consolidation and potential strategic partnerships [5]

Core Viewpoint - Penumbra, Inc. has received FDA clearance for the Ruby® XL System, which is the longest, largest, and softest coil available for vascular embolization, aimed at improving procedural efficiency and patient outcomes [1][2]. Product Features - The Ruby XL System includes three innovative technologies: Ruby XL, POD® XL, and Packing Coil XL, all designed for use with a 0.035" diagnostic catheter [2][8]. - Ruby XL coils can achieve sizes up to 40mm and lengths up to 70 cm, providing more volume per coil than any other on the market, potentially leading to cost savings [2][10]. - The POD XL features a hybrid design with three-in-one coil occlusion technology, suitable for high-flow vessels, while Packing Coil XL utilizes liquid metal wave shape technology for dynamic adjustment to vessel sizes [8][10]. Market Position - With the introduction of the Ruby XL System, Penumbra expands its Ruby portfolio, offering one of the most comprehensive embolization product lines available to physicians [3][4]. - The company emphasizes its commitment to innovation in developing technologies for challenging medical conditions, including ischemic stroke and venous thromboembolism [4].

Core Insights - Autonomix Medical, Inc. has received Ethics Committee authorization to expand its clinical trials for a proprietary ablation technology aimed at treating visceral cancer pain, building on initial success in pancreatic cancer pain [2][3] - The follow-on phase of the clinical program (PoC 2) is set to begin patient enrollment in June 2025, with the potential to double the addressable market by including additional visceral cancers [2][3][4] Group 1: Clinical Development - The PoC 2 phase will evaluate the safety and effectiveness of delivering transvascular energy to ablate problematic nerves, with a focus on interventional cancer pain management applications [2][4] - Initial trials in late-stage pancreatic cancer patients showed promising results, including significant pain reduction and decreased opioid use, indicating the technology's potential to transform cancer pain management [3][4] Group 2: Market Expansion - The expansion into visceral cancer pain aligns with Autonomix's strategy to create long-term value through multi-indication growth, addressing significant unmet needs in cancer treatment [3][4] - The technology platform has the potential to address various indications beyond cancer, including cardiology and chronic pain management, indicating a broad market opportunity [4][6][7] Group 3: Technology Overview - Autonomix's technology includes a catheter-based microchip sensing array designed to detect and differentiate neural signals with greater sensitivity than existing technologies [6][7] - The investigational nature of the technology means it has not yet been cleared for marketing in the United States, highlighting its developmental stage [7]

Company Overview - Kestra Medical Technologies, Ltd. is a wearable medical device and digital healthcare company focused on transforming patient outcomes in cardiovascular disease through innovative monitoring and therapeutic intervention technologies [3]. Leadership Appointment - Conor Hanley has been appointed as an independent director to the board of Kestra Medical Technologies, effective June 4, 2025 [1]. - Brian Webster, President and CEO of Kestra, expressed enthusiasm about Hanley's appointment, highlighting his deep expertise in medical technology and cardiac care as a strategic resource for the company [2]. Conor Hanley's Background - Mr. Hanley is currently the CEO of FIRE1, a venture-backed company focused on connected medical device solutions for heart failure [2]. - He has held senior management roles at ResMed, leading the cardiology business unit and chronic disease management solutions globally [2]. - Hanley co-founded and served as CEO of BiancaMed, a medical device company acquired by ResMed, and holds a PhD in chemical engineering and an MBA [2]. Strategic Focus - Mr. Hanley expressed his honor in joining the Kestra board and emphasized the company's role in driving innovation in the wearable cardioverter defibrillator market [3]. - The company aims to scale its operations and fulfill its commitments to patients and prescribers [3].